Term
| Canine Atopic Dermatitis Pathogenesis |
|
Definition
allergen exposure percutaneously
skin is leakier than normal which makes absorption of antigens and loss of water easier
inflammation makes the skin leakier and worse
antigen is processed by Langerhans cell and keratinocytes in skin
present antigens to T-helper and B-cells to stimulate Ig production
Ig produced by regional lymph nodes
increased numbers of dermal Langerhan's cells
increased T helper (Th2) cells
Th2 cells induce B cells to produce IgE
Th2 secrete cytokines which stimulate mast cells |
|
|
Term
| Canine Atopic Dermatitis Therapy |
|
Definition
targets Th2 cells and its cytokines
want to treat inflammation and secondary infections
prevent self-trauma
bathing helps remove surface allergens and organisms and delivers topical medications to skin |
|
|
Term
| Inflammation and Canine Atopic Dermatitis |
|
Definition
inflamed skin has disruption of permeability barreri and increased allergen absorption which leads to greater inflammation
cycles |
|
|
Term
| Antibodies with Canine Atopic Dermatitis |
|
Definition
There are IgE and IgGd that are bound to mast cells
most invitro assays were designed to detect only IgE and thus may not detect allergies in dogs with IgGd antibodies against allergens |
|
|
Term
| Canine Atopic Dermatitis Signs |
|
Definition
pruritis
erythema
alopecia
papules
excoriation
hyperpigmentation
lichenification
seborrhea |
|
|
Term
| Canine Atopic Dermatitis Distribution |
|
Definition
face-muzzle, periocular
axilla, feet, elbow
generalized in chronic cases |
|
|
Term
|
Definition
most are between 6 months and 3 years old
could happen when move to new environment
there is hereditary tendency
can be seasonal or year rounds |
|
|
Term
|
Definition
blocks H1 and H2 receptors
stabilized mast cells
has some sleepy effects which helps them to stop itching
Diphenhydramine, Clemastine, Hydroxyzine, Chlorpheniramine
Diphenhydramine is a much higher dose than what you would think |
|
|
Term
|
Definition
tricyclic antidepressant
inhibits serotonin reuptake
potent antihistamine
has strong anticholinergic disease |
|
|
Term
|
Definition
Gamma linolenic acid favors production of PGE1 which is anti-inflammatory
Omega 3 FA compete with omega 6 FA and result in less inflammatory cytokines, and down regulation inflammation
need to do it for 8-12 weeks because the FA need to get into the cell membranes and you need to have a cell cycle go through in the skin |
|
|
Term
|
Definition
very effective but many side effects
use during flare-ups if short allergy season
induction and maintenance phases |
|
|
Term
|
Definition
targets T cells
inhibts cytokines
decreases IgE receptor on Langerhans cells, antigen processing
decreases histamine release from mast cells
less effective than corticosteroids because of chronicity of disease
give with ketoconazole to decrease the cost which is a p450 inhibitor to decrease its metabolism in the liver
reduce dose if gingival hyperplasia develops |
|
|
