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Addison's Disease
VM 610 Midterm
7
Veterinary Medicine
Professional
11/04/2012

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Term
Primary Hypoadrenocorticism
Definition
destruction of the adrenal cortex due to immune mediated, infection, or neoplasia
causes lack of glucocorticoids and mineralocorticoids
Term
Secondary Hypoadrenocorticism
Definition
decreased ACTH
long-term administration of corticosteroids
deficiency in glucocorticoids only
Term
Atypical Hypoadrenocorticism
Definition
gradual destruction of adrenal tissue
deficiency in glucocorticoids only
mineralocorticoids are within normal limits
Term
Roles of Glucocorticoids
Definition
glucose metabolism and gluconeogenesis
immune system
inflammatory responses
health and integrity of the GI mucosa
stress tolerance
Term
Signs of Glucocorticoid Deficiency
Definition
waxing-waning course to illness
exercise intolerance
gastrointestinal disturbances
weakness
Term
Roles of Mineralocorticoids
Definition
aldosterone
water and electrolyte balance
release triggered by hypovolemia
promotes renal reabsorption of sodium and water
promotes renal excretion of potassium
Term
Signs of Mineralocorticoid Deficiency
Definition
hyperkalemia
hyponatremia
hypovolemia
weakness
PU/PD
hypovolemic shock
cardiac arrhythmias
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