Term
|
Definition
- water balance homeotasis - regulates blood volume, maintaining proper water, salts, and acid/base balance - produces: renin, erythropoietin |
|
|
Term
| What is the function of renin? |
|
Definition
- increases blood pressure - produced by kidney |
|
|
Term
| what is the function of erythropoietin? |
|
Definition
| - increases RBC production |
|
|
Term
| The kidney is in a ____ position in the ___ ___ region. |
|
Definition
- retroperitoneal - superior lumbar |
|
|
Term
| The kidney extends from the ___ ___ vertebrae to the ____ ___ ___. |
|
Definition
- 12th thoracic vertebrae - 3rd lumbar vertebrae |
|
|
Term
| The right kidney is close to the ___ and sits ___ than the left kidney. |
|
Definition
|
|
Term
| The adult kidney weighs ___ grams and is ___ x ___ x ___. The lateral surface is ___, while the medial surface is ___. |
|
Definition
- 150 - 5 in x 2.5 in x 1 inch - convex - concave |
|
|
Term
| The ___ ___ is found on the medial ___ surface of the kidney and leads to the ___ ___. |
|
Definition
- renal hilus - concave - renal sinus |
|
|
Term
| Structures entering/leaving the hilus: |
|
Definition
- renal veins - renal arteries - ureter and medial part of renal pelvis - lymphatic vessels - nerves
from anterior to posterior: renal vein, renal artery, ureter |
|
|
Term
| Supportive tissue of the kidney includes the fibrous ___ __ which adheres directly to the surface of the kidney. ___ fat acts a cushion from external blows. |
|
Definition
- renal capsule - perirenal fat |
|
|
Term
| The ___ ___ of ___ is the outermost layer of dense, fibrous connective tissue, that anchors the kidneys and adrenal glands to surrounding structures. |
|
Definition
|
|
Term
| The ____ fat is the outermost layer of fat that adheres to the posterior abdominal wall. Both fat layers give support to the kidneys and keep them in place. |
|
Definition
|
|
Term
| from outermost to innermost linings of the kidneys: |
|
Definition
| - peritoneum > pararenal fat > renal fascia of gerota> perirenal fat> fibrous renal capsule> kidney |
|
|
Term
|
Definition
- when the kidney falls to a lower than normal position - can cause the ureter to kink, causing urine to back up in the kidney, leading to increased internal pressure = hydronephrosis - hydronephrosis means water in the kidney, can damage the kidney and lead to necrosis - often seen with anorexia b/c loss of supportive fat around the kidneys |
|
|
Term
|
Definition
- increased pressure in the kidney due to backed up urine from kinked ureter from ptosis of kidney - seen with anorexia |
|
|
Term
| Internal kidney. The __ ___ is the most superficial region. It has parts that dip down into spaces between pyramids to form __ ___. |
|
Definition
- adrenal cortex - renal columns |
|
|
Term
| The cortex is lighter in color with a granular appearance. The renal medulla is deep to the cortex, with a ___ ____ color. |
|
Definition
|
|
Term
| cone shaped masses are called: |
|
Definition
| - renal or medullary pyarmids |
|
|
Term
| Renal pyramids have a broad ___ that faces the cortex and a ___ aka ___ that points internally. |
|
Definition
|
|
Term
| renal pelvis is formed by merging ___ ____. |
|
Definition
|
|
Term
| ___ ___ of ____ are inward extensions of cortical tissue and are found between the pyramids. |
|
Definition
| - Renal columns of Bertin |
|
|
Term
| what constitutes a renal lobe: |
|
Definition
| - renal pyramid with adjacent cap of cortical tissue and cortical columns |
|
|
Term
| papilla > minor calyx> major calyx> renal pelvis> ureter |
|
Definition
|
|
Term
| walls of the calyces and renal pelvis contain ___ ___ for peristalsis. |
|
Definition
|
|
Term
|
Definition
| - infection of renal pelvis and calyces |
|
|
Term
|
Definition
| - an infection or inflammatory condition that affects the entire kidney |
|
|
Term
| kidney infections in females: |
|
Definition
- usually caused by fecal bacteria E.coli - usually spread from anal region to urinary tract |
|
|
Term
| sometimes kidney infections can result form ___ ___ bacteria. |
|
Definition
|
|
Term
| Urinary tract infections are common in hospitals b/c of ____. |
|
Definition
|
|
Term
| Renal arteries are large and deliver ___ of the total ___ ____ ___ to the kidneys every minute. They branch from the abdominal aorta at right angles and are between the __ and ___ vertebrae. |
|
Definition
- 1/4 - systemic cardiac output - L1 and L2 |
|
|
Term
| so every 4 minutes the kidneys process the entire volume of your blood. |
|
Definition
|
|
Term
| The ___ renal artery is longer than the ___ renal artery. |
|
Definition
| - right renal artery longer than left renal artery |
|
|
Term
| renal arteries usually branch into five ___ arteries. |
|
Definition
|
|
Term
| more than 90% of the blood supply entering the kidney profuses the ___. |
|
Definition
|
|
Term
| The ___ contains the bulk of nephrons. |
|
Definition
|
|
Term
| renal veins follow the arterial pathway in reverse. |
|
Definition
|
|
Term
| trace blood supply in kidney: |
|
Definition
| - renal artery> segmental arteries> interlobar arteries> arcuate arteries> interlobular arteries |
|
|
Term
| what three arteries contribute to afferent arterioles, trace the blood flow: |
|
Definition
| - interolobar, arcuate, and interlobular arteries>> afferent arterioles>>glomerulus> efferent arterioles> peritubular capillary network |
|
|
Term
| ___ arterioles feed the glomerulus. |
|
Definition
|
|
Term
| nerve supply to the kidneys and ureter: |
|
Definition
| Renal plexus and ganglion (branch off of celiac plexus and ganglion) |
|
|
Term
| Renal plexus is supplied by sympathetic fibers from: |
|
Definition
- least thoracic nerve - first lumbar splanchic nerve |
|
|
Term
| Sympathetic fibers to the kidneys and ureters are ___ fibers that regulate ___ ___ ___ by adjusting the diameter of ___ ___. |
|
Definition
- vasomotor - renal blood flow - renal arterioles |
|
|
Term
| Parasympathetic fibers from the posterior and anterior __ __ contribute to the ___ plexus. |
|
Definition
- vagal trunk - celiac plexus |
|
|
Term
| structural and functional unit of the kidney: |
|
Definition
|
|
Term
| The __ is responsible for urine formation. |
|
Definition
|
|
Term
| over 1 million nephrons per kidney |
|
Definition
|
|
Term
| majority of nephrons reside in the renal ___. |
|
Definition
|
|
Term
| components of the nephron: |
|
Definition
- a dilated renal corpuscle- Bowman's capsule - proximal convoluted tubule - loop of Henle - distal convoluted tubule
All of these structures together are called the renal tubule. So you could say the nephron is made up of renal tubule. |
|
|
Term
| Urine from several renal tubules drain into __ ___. |
|
Definition
|
|
Term
| nephrons are supplied directly by the ___ ___. |
|
Definition
|
|
Term
| The renal corpuscle is formed by the : |
|
Definition
- glomerulus - Bowman's capsule |
|
|
Term
| A ___ is a tuft of capillaries found inside of Bowman's capsule. These two structures together are called a ___ ___. |
|
Definition
- glomerulus - renal corpuscle |
|
|
Term
|
Definition
- end of the renal tubule - blind-ended, enlarged, and cup shaped tube - completely surrounds the glomerulus |
|
|
Term
| look at slide 34 of this lecture and understand. |
|
Definition
|
|
Term
| Bowman's capsule is connected to the ___ ___ ___. |
|
Definition
| proximal convoluted tubule |
|
|
Term
| ___ ___ feed the capillary bed aka ___ of the nephron. ___ ___ drain this capillary bed. |
|
Definition
- Afferent arterioles - glomerulus - Efferent arterioles |
|
|
Term
|
Definition
- arise from efferent arterioles - are adapted for absorption of solutes and water - are found close to renal tubules - empty into interlobular veins of the renal venous system |
|
|
Term
| peritubular capillaries empty into: |
|
Definition
|
|
Term
| not until the collecting duct is it considered urine, before then in PCT, loop of Henle, and DCT, it is filtrate. |
|
Definition
|
|
Term
| Renal corpuslces are found only in the ___. |
|
Definition
|
|
Term
| renal corpuscles represent the initial epanded part of the ____. |
|
Definition
|
|
Term
| Renal corpuscles have a ___ pole and a ___ pole. |
|
Definition
|
|
Term
| Each renal corpuscle consists of : |
|
Definition
- epithelial part= Bowman's capsule - vascular part= glomerulus |
|
|
Term
| Bowman's capsule is a ___ ___ __that forms the corpuslce's ___ ___. |
|
Definition
- double epithelial layer - external covering |
|
|
Term
| List the two epithelial layers of Bowman's capsule: |
|
Definition
- Parietal layer: outer layer of simple squamous epithelium resting on a basal lamina - Visceral layer: inner layer of capsule consists of specialized cells called podocytes |
|
|
Term
| ____ cover the capillary loops of the glomerulus and are in direct contact with the basal lamina of the glomerular capillaries. |
|
Definition
|
|
Term
| ___ ___ is between the parietal layer and visceral layer of Bowman's capsule. |
|
Definition
|
|
Term
| look at slides 38 and 39 of this lecture for histology |
|
Definition
|
|
Term
| Filtrate passes from the __ in ___ ___ to ___ ___. |
|
Definition
- blood in glomerular capillaries - urinary space |
|
|
Term
| 3 closely apposed structures of the renal corpuscle: |
|
Definition
- glomerular capillary endothelium - basal lamina - visceral layer of Bowman' capsule with podocytes |
|
|
Term
| The lining of the glomerular capillaries is an ____ ____ with numerous ____. |
|
Definition
- attenuated endothelium - fenestrae |
|
|
Term
|
Definition
|
|
Term
| External to the capillary endothelium is a continuous ___ ___ and ___ cover the outer endothelium. |
|
Definition
- basal lamina - podocytes |
|
|
Term
| The filtration barrier of the renal corpuscle is formed by: |
|
Definition
- fenestrated endothelial cells of glomerular capillaries - basal lamina- prevents passage of large cells - filtration slits b/w pedicels of podocytes (visceral layer of bowman's capsule) |
|
|
Term
| podocytes are highly specialized cells that form the ___ ___of ___ ___. |
|
Definition
| - visceral layer of Bowman's capsule |
|
|
Term
| Each podocyte has several ___ ___ called ____ that give rise to ___ ___ that terminate as ____. Adjacent ____ interdigitate and form a series of ___ __. A thin non-membranous diaphragm termed the slit membrane spans each filtration slit. |
|
Definition
- primary processes called trabeculae - secondary processes - pedicels - pedicels - filtration slits |
|
|
Term
| look at slides 41-51 for histology |
|
Definition
|
|
Term
| The proximal convoluted tubule is mainly in the ___ and is made of ___ ___ or ___ epithelium. Its apical border is a ___ ___ containing many ____. |
|
Definition
- cortex - simple cuboidal or columnar - brush border - microvilli |
|
|
Term
| The cytoplasm of the proximal convoluted tubule contains many ____. The PCT is important for ___ and ___. |
|
Definition
- mitochondria - absorption - transport |
|
|
Term
| The PCT absorbs macromolecules via ___ and uses ___ ___ __ out of cells. It absorbs all the ___ and ___ ___ and 85% of the ___ ___. Water ___ ___ following the ___ ___. |
|
Definition
- pinocytosis - active sodium transport - glucose - amino acids - sodium chloride - diffuses passively - osmotic gradient |
|
|
Term
| 90% of malignant kidney tumors are found where? |
|
Definition
| - proximal convoluted tubule |
|
|
Term
| The distal convoluted tubule is made of ___ ___ epithelium and does not have a ___ ___. It is located in the ___ of the kidney. |
|
Definition
- simple cuboidal - no brush border - cortex |
|
|
Term
| The ___ __ is a modified portion of the distal convoluted tubule where it lies adjacent with the ___ __ of the renal corpuscle. |
|
Definition
- macula densa - vascular pole |
|
|
Term
| ___ acts on cells of the distal convoluted tubule to absorb more ___ and ___ ions. |
|
Definition
- Aldosterone - sodium - chloride |
|
|
Term
| The juxtaglomerular complex is located near the ____ ___ of the ___ ___. |
|
Definition
- vascular pole - renal corpuscle |
|
|
Term
| The ___ ___ limb of the ___ ___ __ contacts the vacular pole between the ___ and ____ arterioles. |
|
Definition
- ascending thick - distal convoluted tubule - afferent and efferent arterioles |
|
|
Term
|
Definition
| cluster of tightly packed cells in the DCT |
|
|
Term
| ___ ___ of the afferent arteriole are modified smooth muscle cells that secrete ___. |
|
Definition
- Juxtaglomerular cells - renin |
|
|
Term
| The DCT has the ___ __, while the afferent arteriole has the ___ ___ that secrete ___. |
|
Definition
- macula densa - juxtaglomerular cells - renin |
|
|
Term
| Juxtaglomerular cells of the ___ ___ are modified ___ ___ cells that secrete ___. |
|
Definition
- afferent arteriole - smooth muscle - renin |
|
|
Term
Regulation of Blood pressure: - Renin acts on ___ ____ ___ producing ___ __. - A converting enzyme makes ___ __ from angiotension I. - ___ _ increases blood pressure by ___ ___ and stimulating ___ ___ from the ___ ___. - ___ acts on cells of the distal convoluted tubule to increase absorption of sodium and chloride ions. This expands fluid volume and blood pressure. |
|
Definition
- plasma protein angiotension - Angiotension I - Angiotension II - Angiotension II - contricting arterioles - aldosterone secretion - adrenal glands - Aldosterone |
|
|
Term
| what interaction produces angiotension I? |
|
Definition
| - renin (from the juxtaglomerular complex in the afferent arteriole) acting on plasma protein angiotension |
|
|
Term
| converting enzyme converts what to what? |
|
Definition
| - angiotension I to angiotension II |
|
|
Term
| How does angiotension II increase blood pressure? |
|
Definition
- constricts arterioles - stimulated aldosterone secretion of adrenal glands |
|
|
Term
| what does aldosterone do? |
|
Definition
- acts on cells of distal convoluted tubule to absorb sodium and chloride ions - water follows> increased blood volume> increase blood pressure |
|
|
Term
Loop of Henle: - thick descending loop is similar in structure to the ___. - thin descending loop is ___ ___ epithlium, in the ___ of the kidney - thin ascending loop is ___ ___ epithelium in the ___ of the kidney. - thick ascending loop is similar in structure to __. |
|
Definition
- PCT - simple squamous, medulla - simple squamous, medulla - DCT |
|
|
Term
| The loop of Henle is permeable to ___ ___. |
|
Definition
|
|
Term
| Ureters are long slender tubes that convey urine from the kidney to the urinary bladder. They begin at level of __ as a continuation of the ___ ___. They descend behind the ___to the base of the bladder, turn medial and then run oblique through posterior wall of bladder. Path prevents backflow of urine into ureters during bladder filling. |
|
Definition
- L2 - renal pelvis - peritoneum |
|
|
Term
| 3 sites of constriction of the ureter: |
|
Definition
- uretopelvic junction- near hilus - where they cross the iliac vessels- pelvic brim - where they join the bladder |
|
|
Term
|
Definition
- mucosa - muscularis - adventitia |
|
|
Term
| describe the ureter mucosa: |
|
Definition
- highly convoluted - thick transitional epithelium - continous with that of the kidney, pelvis, and urinary bladder |
|
|
Term
| describe ureter muscularis: |
|
Definition
| - two sheets: inner longitudinal , outer ciruclar, upper part is 2 sheets, lower part near bladder is 3 sheets |
|
|
Term
| describe ureter adventitia: |
|
Definition
| fibrous connective tissue covering |
|
|
Term
| Distention of the ureter by incoming urine stimulates: |
|
Definition
| - the muscularis of the ureter to contract> peristalsis, propells urine into bladder |
|
|
Term
| The vigor and frequency of the peristaltic waves are controlled by the rate of __ ___. |
|
Definition
|
|
Term
| ureter has an inner ___ muscle layer and an outer ___ muscle layer. |
|
Definition
- inner longitudinal - outer circular |
|
|
Term
|
Definition
|
|
Term
| Kidney stones are crystals of ___, ___, or __ __ ___. These are called ___ ___. They precipitate in the ___ __. Most are small, less than 5 mm, and pass undetected. Larger calculi can block a ureter and prevent urine passage. Causes pain in __ wall of __ from increased pressure in the kidney. |
|
Definition
- calcium, magnesium, uric acid salts - renal calculi - renal pelvis - posterior wall of the abdomen |
|
|
Term
|
Definition
- frequent urinary tract infections (bacteria) and holding of urine - high blood calcium and alkaline urine |
|
|
Term
|
Definition
| shock wave that shatters kidney stones |
|
|
Term
| prevention of kidney stones: |
|
Definition
- acidifying the urine by drinking cranberry juice - ingesting lots of water to dilute urine |
|
|
Term
| The bladder is a smooth collapsible muscular sac that temporarily stores urine it is located ___ on the ___ ___, just posterior to the ___ ___. |
|
Definition
- retroperitoneally - pelvic floor - pubic symphysis |
|
|
Term
urinary bladder: Females - lies anterior to the vagina and uterus Males - lies anterior to the rectum and superior to the prostate gland that surrounds its inferior neck |
|
Definition
|
|
Term
| three layers in bladder wall: |
|
Definition
- mucosa - muscularis - adventitia |
|
|
Term
| describe mucosa of the bladder wall: |
|
Definition
| - transitional epithelium |
|
|
Term
| describe muscularis of bladder wall: |
|
Definition
thick, muscular layer called the detrusor muscle consisting of intermediate smooth muscle fibers arranged in inner and outer longitudinal layers and a middle circular layer |
|
|
Term
| describe adventitia of bladder: |
|
Definition
fibrous layer covers the bladder except on its superior surface superior surface covered by the parietal peritoneum |
|
|
Term
| Interior part of the bladder has three openings for: |
|
Definition
|
|
Term
| smooth triangular region on base of bladder between the three openings is called the: |
|
Definition
|
|
Term
| Between the two openings of the ureters is the: |
|
Definition
|
|
Term
|
Definition
| it collapses into its basic pyramidal shape |
|
|
Term
| Thick walls of urinary bladder form: |
|
Definition
|
|
Term
| as urine accumulates the bladder: |
|
Definition
- becomes pear shaped and rises superiorly - muscle wall stretches and rugae disappear - stretching triggers micturition/voiding |
|
|
Term
| normal capacity of bladder is 300-500 mL, cut can hold twice this. |
|
Definition
|
|
Term
| The urethra is a thin walled muscular tube. Near the bladder it is ___ epithelium, then its mostly ___ ___ epithelium, then near its opening it becomes ___ __ ___ epithelium. |
|
Definition
- transitional - pseudostratifed columnar - simple squamous non-keratinized |
|
|
Term
| in females the urethra is 1.5 inches long and bound to the vagina by fibrous connective tissue. |
|
Definition
|
|
Term
| External urethral orifice aka meatus: |
|
Definition
- external opening of urethra - anterior to vagina, posterior to clitoris |
|
|
Term
| In males urethra is 8 inches long and has three regions, list them: |
|
Definition
- prostatic urethra - membranous urethra- goes through urogenital diaphragm(sphincter urethra muscle) - spongy (penile) urethra- passes through penis and opens at tip via external urethral orficice
MALE URETHRA CARRIES SEMEN AND URINE OUT OF BODY |
|
|