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zMolecular Targets of Cancer
Biochemical and Molecular Principles of Drug Action Biochemical and Molecular Principles of Drug Action
12
Pharmacology
Professional
03/14/2012

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Cards

Term
APC
Definition
Inactivation moves Stem cells to Aberrant crypt cell
Term
B-Catenin
Definition
Activation moves Stem cells to Aberrant crypt cell
Term
Ras
Definition
Activation moves Aberrant crypt cell to Early Adenoma
Term
TGF-BRII Smads
Definition
Inactivation moves Early Adenoma to Late Adenoma
Term
p53
Definition
Inactivation moves Late Adenoma to Carcinoma
Term
Herceptin
Definition
Trastuzumab, a recombinant DNA-derived humanized monoclonal antibody, binds to the extracellular domain of the HER2 protein, which is overexpressed in 25 to 30% of primary breast cancers. By binding to the HER2 protein, trastuzumab inhibits the growth of tumor cells and mediates antibody-dependent cellular cytotoxicity (ADCC) in cancer cells that overexpress the HER2 protein
Term
kinase inhibitors type I inhibitors
Definition
arget the ATP binding site of the kinase in its active conformation, in which the activation loop is phosphorylated
Term
kinase inhibitors type II inhibitors
Definition
have revealed a new binding mode that exploits an additional binding site immediately adjacent to the region occupied by ATP. This pocket is made accessible by an activation-loop rearrangement that is characteristic of kinases in an inactive conformation
Term
kinase inhibitors type III inhibitors
Definition
Term
Pro(death)-apoptosis
Definition
Bak/Bax/Bim
Term
Anti (alive)-apoptosis
Definition
Bcl-2/Bclxl
Term
Angiogenesis in Cancer Therapy
Definition
Monoclonal antibody: Bevacizumab (Anti-VEGF-A)
‚óŹ Small molecule: TKIs
(Sunitinib, Sorafenib, AG013736, ZD6474 etc.)
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