Term
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Definition
| Br2/FeBr3 Benzene -> Benzene-Br |
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Term
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Definition
| Cl2/FeCl3 Benzene -> Benzene-Cl |
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Term
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Definition
| I2/CuCl2 Benzene -> Benzene-I |
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Term
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Definition
| HNO3/H2SO4 Benzene -> Benzene-NO2 |
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Term
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Definition
| SO3/H2SO4 Benzene -> Benzene-SO3H |
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Term
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Definition
CH3Cl/AlCl3 Benzene -> Benzene-CH3
CHC(=O)Cl/AlCl3 Benzene -> Benzene-C(=O)CH3
1.R-X must be alkyl halide. Vinyl or aryl won’t work
2.Does not work on strongly deactivated rings
3.No reaction if NH2, NHR, or NR2 on ring
4.Alkyl is activating. Second alkylation faster than first.
Reaction only practical with large excess of benzene so that statistics control product ratio.
5.1° R+ rearranges to more stable 2° |
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Term
| Reduction of aromatic nitro groups |
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Definition
| 1.Fe,H3O+/2.HO- Benzene-NO2 -> Benzene-NH2 |
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Term
| Nucleophilic aromatic substitution by addition to activated aryl halides |
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Definition
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Term
| Nucleophilic aromatic substitution by formation of benzyne intermediate from unactivated aryl halide |
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Definition
| Na+ -NH2/NH3 Benzene-Br -> Benzene-NH2 |
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Term
| Oxidation of alkylbenzene side chain |
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Definition
| KMnO4/H2O Benzene-CH3 -> Benzene-COOH |
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Term
| Benzylic bromination of alkylbenzene side chain |
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Definition
| NBS/CCl4 Benzene-Ch3 -> Benzene-CH2Br |
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Term
| Catalytic hydrogenation or aromatic rings |
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Definition
| H2/(Rh/C) catalyst Benzene -> cyclohexane |
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Term
| Reduction of aryl alkyl ketones |
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Definition
| (H2/Pd)/ethanol Benzene-C(=O)-R -> Benzene-CH2-R |
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