Acetylcholine (Miochol-E)

• Treats

Direct Acting Muscarinic Agonist

• Treat glaucoma

Methacholine (Provocholine)

• use

Direct Acting Muscarinic Agonist

• pulmonary function testing in asthma

bethanechol (Urecholine)

• Treats

Direct Acting Muscarinic Agonist

• GI motility
• Treat urine retention

pilocarpine (Salagen/Ocusert Pilo)

• Treats

Direct Acting Muscarinic Agonist

• Treat glaucoma
• Treat xerostomia

Edrophonium (Tensilon)

• Use

Reversible cholinesterase inhibitor

• Diagnose MG

physostigmine/eserine (Antilirium)

• Use

Reversible cholinesterase inhibitor

• Antidote to antimuscarinic OD

Neostigmine (Prostigmin)

• Treats

Reversible cholinesterase inhibitor

• Treat MG

pyridostigmine (Mestinon)

• Treats

Reversible cholinesterase inhibitor

• Treat MG
• Pre-exposure protection by army

rivastigmine (Exelon)

• Treats

Reversible cholinesterase inhibitor

• Treat alzheimer's

donepezil (Aricept)

• Treats

Reversible cholinesterase inhibitor

• Treat Alzheimer's

reversible cholinesterase inhibitor

vardenafil (Levitra)

Pralidoxime/2-p AM (Protopam)

• use

Cholinesterase Reactivator

• Counters organophosphates (given within 2 hours)
• Counters nerve agents like Sarin

Atropine, Hyoscyamine and Homatropine

• Use

Muscarinic antagonists (Anticholinergics)

• Antidote to ACH OD
• Preoperative to block vagal to heart

Muscarinic antagonists (Anticholinergics)

• Treat motion sickness

Dicyclomine (Bentyl)

• Treats

Muscarinic antagonists (Anticholinergics)

• Intestinal antispasmatic for IBS

Propantheline

• Treats

Muscarinic antagonists (Anticholinergics)

• GI antispasmdic to treat IBS

Glycopyrrolate (Robinul)

• Use

Muscarinic antagonists (Anticholinergics)

• anesthetic to dry secretions
• inhibit vagal reflexes

Ipratropium (Atrovent)

• Treats

Muscarinic antagonists (Anticholinergics)

• Asthma

Tiatropium (Spiriva)

• Treats

Muscarinic antagonists (Anticholinergics)

• Asthma

benztropine (Cogentin)

• Treats

Muscarinic antagonists (Anticholinergics)

• Treat Parkinson's

Tolterodine (Detrol)

• Treats

Muscarinic antagonists (Anticholinergics)

• Treat urinary incontinence

Selective β₁-agonist

• Treat cardiogenic shock
• Start heart back up again

Selective β₂-agonist

• Uterine relax

Selective α₁-agonists

• Dilate eyes without causing cycloplagia

Indirect-acting Sympathomimetics

• Treat stress induced urinary incontinance

Acebutolol (Sectral)

• Blocks
• Partial agonist?
• Membrane stabalizing?
• Lipid solubility?

• β1 blocker
• partial agonist
• membrane stabilizing
• Low lipid solubility

Atenolol (Tenormin)

• Blocks
• Partial agonist?
• Membrane stabalizing?
• Lipid solubility?

• β1 blocker
• Not partial agonist
• Not membrane stabalizing
• Low lipid solubility

Esmolol (Brevibloc)

• Blocks
• Partial agonist?
• Membrane stabalizing?
• Lipid solubility?

• Blocks β1
• Not partial agonist
• Not membrane stabalizing
• Low lipid solubility

Metoprolol (Lopressor, Toprol XL)

• Blocks
• Partial agonist?
• Membrane stabalizing?
• Lipid solubility?

• Blocks β1
• Not partial agonist
• Membrane stabalizing
• Medium Lipid solubility

Worsens raynaulds

Nadolol (Corgard)

• Blocks
• Partial agonist?
• Membrane stabalizing?
• Lipid solubility?

• Blocks β1 & β2
• Not Partial agonist
• Non Membrane stabalizing
• Low lipid solubility

Pindolol

• Blocks
• Partial agonist?
• Membrane stabalizing?
• Lipid solubility?

• Blocks β1, β2
• Partial agonist
• Membrane stabalizing
• Medium lipid solubility?

Propranolol (Inderal-LA)

• Blocks
• Partial agonist?
• Membrane stabalizing?
• Lipid solubility?

• Blocks β1, β2
• not Partial agonist
• Membrane stabalizing
• High lipid solubility

Timolol (Timoptic)

• Blocks
• Partial agonist?
• Membrane stabalizing?
• Lipid solubility?

• Blocks β1,β2
• Not partial agonist
• Not membrane stabalizing
• Medium lipid solubility
• Treat glaucoma

Labetalol (Trandate)

• Treats

• Blocks α, β
• Treat hypertension

Phentolamine (OraVerse)

• Treats

• Non selective α1α2 blocker
• Treat pheochromocytoma
• Counter tissue necrosis 
• counter oral anesthetics

Prazosin (Minipress)

• Treats

• Selective α1 blocker
• Treat hypertension
• Treat BPH
• Treat raynauds
• treat PTSD

Doxazosin (Cardura)

• Treats

• Selective α1 blocker
• Treat hypertension
• Treat BPH
• Treat raynauds
• treat PTSD

Tamsulosin (Flomax)

• Treats

• Selective α1 blocker
• Treat BPH

Reserpine

• Use

• peripheral acting sympathetic neuronal blocker
• Decrease NE, Da into vessicles.  LA
• Lowers BP

Methyldops

• Treats

• Centrally acting sympathetic neuronal blocker
• prodrug. α agonist at CNS to lowr outflow of sympatheti activity
• lower renin release
• treat hypertension during pregnancy
• induce autoimmune disorders

Clonidine (Catapres)

• Use

• Centrally acting sympathetic neuronal blocker
• patch
• lowers BP, migraine, ADHD, PTSD, hot flashes

Nicotine

• Heart
• Vessels
• Eye
• GI
• Bladder

(Ganglionic stimulant)

• Heart: Tachycardia, ↓ contractility
• Vessels: vasodilation, ↓TPR
• Eye: Mydriasis, cycloplegia
• GI: ↓tone, motility, secretion
• Bladder: urine retention

• Dopaminergic agent

Bromocriptine (Parlodel)

• Use

• Dopaminergic agent
• second choice, less on-off
• decreases lactation

Pramipexole (Mirapex)

• Treat

• Dopaminergic agent
• Also usefull for restless leg

Ropinerole (Requip)

• Treat

• Dopaminergic agent
• also usefull for RLS

• Dopaminergic agent
• Stimulate release of dopamine.

• MAO-B inhibitor

• COMT inhibitor

• Antihistamine
• blocks muscarinic as SE

• MOA unknown
• Drug deposits in tissue
• Eye toxicity irreversible

• Inhibit macrophage phagocytosis and enzyme release
• Diarrhea, Dermatologic, stomatitis

• Immunosuppressive
• Anorexia, HA, NV
• Neutrapenia

• Inhibit pyrimidine synthesis
• Inhibit dihydroorotate dehydrogenase
• GI, Hepatotoxicity, Hematological, Hypersensitivity

• Dimeric fusion protein          Human + Human
• Binds TNF α/β
• Hypersensitivity infections & sepsis

• Chimeric Human + Murine
• neutralizes TNFα only
• Hypersensitivity, immunosuppressive,

Cyclophosphamide

• MOA

• Prodrug
• Non-specific alkylating agent
• Inhibit signal 3

Azathioprine

MOA

• Antimetabolite
• Signal 3
• Affects adenosine deaminase

Methotrexate

MOA

• Inhibit dihydropholate reductase
• Signal 3

Cyclosporine

MOA

• inhibit calcineurin Phosphatases
• inhibit release of IL2
• Signal 1
• Nephrotoxic

Mycophenolate

MOA

• Inhibit Inosine monophosphate Dehydrogenase.  purine metabolism
• Signal 3

Muromonab-CD3

MOA

• Murine clonal antibody
• Blocks CD3
• Signal 1

• suppresses Immune response of Rh-negative individual to Rh-positive RBC
• Signal 1

Immune Globulin

MOA

• Passive immunity increased
• Signal 1
• for immunosuppressed patients

• Growth of stem cells into RBC
• Treats anemia of chronic diseases (AIDS, Cancer, before surgery)

• Growth of neutrophils

• Growth of granulocytes and macrophages

Carmustine

• MOA
• Specific?

• Alkylating agent
• Nonspecific

Cisplatin

• MOA
• Specific?

• Alkylating agent
• Nonspecific

Mercaptopurine

• MOA
• Specific?

• Purine analog
• S

Fluorouracil

• MOA
• Specific?

• Pyrimidine analog
• S

Cytarabine

• MOA
• Specific?

• Antimetabolite
• S

Class 1A

Slows conduction velocity of phase 0

↑ AP duration

↑ refractory period

(interact medium with Na channels)

Class 1A

(inhibits Na, metabolite inhibits K)

Slows conduction velocity of phase 0

↑ AP duration

↑ refractory period

(interact medium with Na channels)

CLass 1B

Slows conduction velocity of phase 0

↓ AP duration

↓ Refractory period

(Interact fast with Na channels)

Class 1C

Greatly Slows conduction velocity of phase 0

↑ AP duration

↑ refractory period

(interact slowly with Na channels)

• Inhibit Thromboxane synthesis

(Cox1 inhibitor)

• Inhibits phosphodiesterase
• ↑cAMP
• ↓ TXA2 production.
• Blocks platelet adhesion to vessels

• Inhibit ADP binding to platelet receptor (irreversible)

• Binds Antithrombin III, ↑ activity

• Blocks vitamin K
• Inhibit synthesis of factors & anticoagulent proteins.

• Binds & blocks thrombin
• for patients with heparin induced thrombocytopenia.

• Binds and activates plasminogen
• (Antigenic)

• Binds and activates plasminogen
• (non-antigenic)

• causes plasminogen to have greater affinity for fibrin.

• Hemophilia A

• Hemophilia B

• Counter Coumadin
• Newborn hemorrhagic disease

α1/β Blocker

and NO-releasing β1 blocker

Calcium Channel Blocker

(Heart)

Calcium Channel Blocker

(Heart)

Direct Vasodilator

(Preload)

Direct Vasodilator

(Preload)

stimulate release of insulin

(Blood glucose concentration dependent)

Glucosidease inhibitor

delays digestion of sugars

Incretin mimetic

↑ Glucose dependent insulin release

↓ Glucagon secretion

↓ Gastric emptying

feeling of fullness

DPP-IV inhibitor

inhibits degredation of incretin

Amylin analog

Slows gastric emptying

Inhibits glucagon secretion

Feeling full

Alprazolam

Benzodiazepine

Muscle relaxent

Non Benzi sleap aid

Enhances effects of GABA

Sleap aid

short acting

Haldol

• How
• Off label

• Blocks DA, ↑ACH.  (High EPS, low Anticholinergic)
• Hiccup, tic, mania, scitzo

Clozapine

• How
• Toxicity
• Special

• Atypic Antipsychotic
• Blocks D4 & 5HT
• Agranulocytosis, high Anticholinergic
• no EPS

Aripiprazole (Abilify)

• What
• How

• Atypic antipsychotic
• Partial agonist at D2 and 5HT

Imipramine

• What
• How
• Uses

• Tricyclic
• Blocks reuptake of NE & Serotonin
• Pain from peripheral neuropathy, Migraine, Muscarinic antagonist, enuresis

Amitriptyline (Elavil)

• What
• How

• Tricyclic
• Blocks reuptake of NE & Serotonin

• SSRI

Sertraline (Zoloft)

• What

• SSRI

Paroxitene (Paxil)

• What

• SSRI
• Short acting, no metabolites

Venlafaxine

• What

• SNRI

Trazadone

• What

• 5HT reuptake blocker & receptor blocker
• Very sedating

Bupropion

How

• DA reuptake inhibitor

Atomoxetine (Stratera)

• How

• NE RI

Phenelzine

• How

• MAO Inhibitor

Tranylcypromine

• How

• MAO Inhibitor

Cocaine

• How

• DA reuptake inhibitor

Evista

• Indications

Treat osteoporosis

(SERM)

Clomiphene

• Indication

fertility

(SERM)

Penicillinase resistant

(anti Staph)

Penicillinase resistant

(anti Staph)

Penicillinase resistant

(anti Staph)

Vancomycin

• MOA
• Resistance

• Bind D-alanyl D-alanine, inhibit cell wall
• change in cell wall enzymes

Clindamycin

• MOA
• Resistance

• Bind 50s
• Mutation in 50s

Nitrofurantoin

MOA

Polymixin B

• MOA
• Resistance

• Cationic detergent
• inhibit from entering cell

Metronidazole

• MOA

• Binds intracellular molecules

Metrosexuals like hugs, they bind to everyone

Bacitracin

• MOA

Quinuprestin/Dalfopristin

• MOA

Linezolid

• MOA
• Resistance

• Bind 50s
• mutated 50s

Daptomycin

• MOA

• Binds cell wall

Inhibit microtubule mediated glucose uptake

"bend the tubes so the helminths can't suck up sugar"

Pyrantel Pamoate MOA:

Depolarizing neuromuscular blockade

"When I see Pam, I am paralized"

• Ca influx: contractions then paralysis
• Shistosomes become dislodged

In CA I recieved a present.  I was so excited that I was contracting, then I lost interest and became still like paralysis

Influenza A

XC: Parkinson's

(If a man flew, then he is superman)

• Respiratory syncytial viral infection
• Chronic hepatitis C (+ IF α-2A)

the ribbon wraps around you, so you can't C and you can't breath

• Herpes simplex Keratitis

"her flowers"

• Herpes

• Cytomegalovirus infections

: you can sit down in that general site over there"

• Cytomegalovirus for AIDs patients

(AIDs haunts me like a scar, )

• Warts
• Hepatitis B and C
• Herpes
• peratoconjunctivitis

(the plagues of egypt comanded by mosus interfered with Pharo's plans.  They included frog warts and liver disease.  All this happened BC)

Isoniazid (INH)

• MOA

• Inhibit mycolic acid biosynthesis
• Analog of B3

Rifampin

• MOA

• Suppress RNA synthesis
• Drug-enzyme complex

Pyrazinamide

• MOA

• converted to POA.  ↓PH = less growth

The pirates make acid

Clofazimine

• MOA

• Binds DNA inhibits growth

throw a cloth over him, so he can't expand

Nystatin

MOA