Term
|
Definition
-the absence of menstrual bleeding AND secondary sexual characteristics (breast development, pubic hair) in a girl by age 14
OR
-the absence of menstrual bleeding with normal development of secondary sexual characteristics in a girl by age 16 |
|
|
Term
| Define secondary amenorrhea |
|
Definition
| the absence of menstrual bleeding in a woman who had been menstruating but later stops menstruating for 3 or more months in the absence of: pregnancy, lactation, cycle suppression with systemic hormonal birth control, menopause |
|
|
Term
| what is the most common cause of secondary amenorrhea? |
|
Definition
|
|
Term
| what is kallman syndrome? |
|
Definition
| the hypothalamus does not release GnRH to signal release of FSH and LH by pituitary. will also generally experience delayed puberty. may have anosmia |
|
|
Term
| what is autoimmune hypophysitis? |
|
Definition
| cells of pituitary gland destroyed by the body's defense system |
|
|
Term
| what does a mutations in the FMR1 gene cause? |
|
Definition
|
|
Term
| when is a work up for amenorrhea warranted? |
|
Definition
| if 3 consecutive menses have been missed |
|
|
Term
| irregular uterine bleeding that occurs in the absence of pathology or medical illness is a diagnosis of __________ |
|
Definition
|
|
Term
| in premenopuasal women with normal findings on PE, the most likely diagnosis for someone with DUB is secondary to ________ |
|
Definition
|
|
Term
| in perimenopausal patients with DUB, what must be considered early in the investigation |
|
Definition
| endometrial bx and other methods of detecting endometrial CA |
|
|
Term
| in postmenopausal women with DUB with is included in the initial investigation? |
|
Definition
| endometrial bx and/or transvaginal US |
|
|
Term
|
Definition
| masculinization with severe hirsutism |
|
|
Term
| what is another name for PCOS? |
|
Definition
|
|
Term
| what hormone is often elevated in PCOS? |
|
Definition
LH
ratio LH:FSH >3:1 (normal 1:1) |
|
|
Term
| what is used for ovulation induction in a pt with PCOS desiring fertility? |
|
Definition
|
|
Term
|
Definition
metformin 500 mg TID or 1000 mg BID with meals (will make the pt very sick, start them low and work your way up)
-Actos 15-30 mg daily
-Avandia 4-8 mg daily
or a combo of these meds |
|
|
Term
| what are three causes of hirsutism/virilzation that should be ruled out before tx for PCOS? |
|
Definition
-androgen producing adrenal tumor
-androgen producing ovarian tumors
-Cushing's syndrome |
|
|
Term
| what is seen with serum testosterone in a pt with PCOS? if prolactin is elevated what does this signal? |
|
Definition
|
|
Term
| if DHEAS is elevated in a pt with PCOS what does this signal? |
|
Definition
|
|
Term
|
Definition
| no conception after one year of regular unprotected intercourse |
|
|
Term
| what are the three broad categories that 90% of reproductive dysfunction can be categorized into? |
|
Definition
| chromosomal, previous STD, abnormal spermatogenesis |
|
|
Term
| what is the number one cause of female infertility in this country? |
|
Definition
|
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