Term
| What causes antigens to be sequestered behind the blood testis barrier in sertoli cells? |
|
Definition
|
|
Term
| How do Sertoli cells suppress immune responses? |
|
Definition
| By secreting TGF-beta and expressing FasL (which causes apoptosis of Fas expressing cells like lymphocytes) |
|
|
Term
| What have macrophages been shown to secrete in testis? |
|
Definition
| IL-10 which inhibits the action of activated T cells |
|
|
Term
| What is found in 12-33% of Premature Ovarian Failure and why? |
|
Definition
| Thyroid Dz. Increased frequency of APS2 compared to APS1 |
|
|
Term
| What is the genetic defect in APS1? |
|
Definition
|
|
Term
| What disease are associated with APS2 and what is its HLA? |
|
Definition
| Addisons, Type 1 Diabetes, and Thyroid Dz. HLA-DR3 |
|
|
