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Week 4
Chapter 15-Antiparasites
37
Pharmacology
Undergraduate 3
11/24/2014

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Term
Ectoparasites
Definition
These parasites live on the surface of the host. They cause external parasite infesations.
Term
Endoparasites
Definition
Thisd type of parasite lives nside the body and cause internal parasite infections.
Term
Helminths
Definition
This tye of endoparasite is a worm found primarily in the GI tract, liver, lungs, & circulatory system. There are 2 major groups: Nematodes & Platyhelminths.
Term
Nematodes
Definition

This slender tube like, non-segmented endoparasite is transmitted through anthropods. Example: Roundworms.

Ascarids, Trichuris, Ancylostoma, Stroggyle, & Dirofilaria.

Term
Platyhelminths
Definition
This type of endoparasite can live in the GI tract or other body tissues. Example: Flatworms. Two kindsL Cestodes: tapeworms, & Trematodes: flukes.
Term
Antiparasitics
Definition
This class of drugs are categorized by the type of parasite they work against.
Term
Anthelmintics
Definition
This category of antiparasitics kill worm parasites, and are further categoriezed into antinematodal, anticestodal. & antitrematodal.
Term
Benzimidazoles
Definition
This category of Antinematodal drugs interfere with worm's energy metabolism. Given PO in repeated doses. Examples: Thiabendazole, Oxibendazole, Mebendazole, & Fenbendazole.
Term
Probenzimadazoles
Definition
This category of antinematodal drugs are probiotics which are metabolized in the animal's body to benzimadazole. Example: Febantel: Dronta Plus.
Term
Imidazothiazoles
Definition
This category of antinematodal drugs is an anticholinergic used to paralyze the parasite. It treats ascarids, strongyles, whipworms, & hookworms. It is not ovicidal.
Term
Tetrahydropyrimidines
Definition
This category of antinematoadal drugs is a cholinergic agonist that mimics the action of Ach which will initialy stimulate and then paralyze the worm. Treats ascarids, pinworms, strongyles, & hookworms. Example: Strongid-T.
Term
Organophosphates
Definition
This category of antinematodal drugs is used vs. both endoparasites and ectoparasites. Should be used with caution in all species. eurotoxic to parasites, but it can cause some neurologic side effects in host animals. Example: Task & Baymix.
Term
Piperzine
Definition
This category of antinematodals is only used to eradicate ascarids in all species. Essentialy nontoxic so it is sold OTC. Examples: Hartz-Health measures.
Term
Avermectins
Definition
This category of antinematodals causes paralysis & death to the parasite. Example: Ivermectin. Heartgard, Ivomec.
Term
Cestodes
Definition
This parasite consists of a head( scolex), neck, & segments (proglottids). It increases in length by producing new segmens from the neck area. Therefore the oldest segments are at the distal end of the worm.
Term
Anticestodal drugs
Definition
This category of antiparasitic drugs includes Praziquantel which increases cell membrane permeability and will cause the worm to disintegrate.
Term
Trematodes
Definition
This parasite is named for the area it effects. It has an immediate host which is usually a snail.
Term
Antitrematodal Drugs
Definition
This category of antiparasitics includes examples such as: Clorsulon which is used for liver flukes in cattle. Albendazole, also treats liver flukes in cattle but not effective vs. some nematodes.
Term
Coccidia
Definition
This parasite is a protozoa that causes various intestinal disorders, dome serious, and even fatal. It has a complex life cycle which makes it hard to treat. Sanitation and disinfection of environment are very important in treatment.
Term
Anticoccidials
Definition
This category of antiparasitic drugs consist of sulfa drugs. Works at various stages of coccidian life cycle. Usually given orally in feed, water, or by liquid or tablets. Examples: Albon, Rumensin, & Deccox.
Term
Antiprotozoals
Definition
This category of antiparasitics works against giardia and Babesia spp. Examples include:
Term
Heartworm
Definition
This disease affects dogs, cats & ferrets. Caused by Dirofilaria immitis. Transmitted by mosquitoes. Adults live in pulmonary artery but can be found in RT ventricle, and RT atrium.
Term
Heartworm preventitive.
Definition
Low doses of Ivermectin (6mcg/ kg) are used as?
Term
Kills microfilariae
Definition
Moderate does of Ivermectin (50mcg/ kg) are used for?
Term
Kills most internal parasites.
Definition
High doses of Ivermectin (200mcg/kg) are used for?
Term
Milbemycin (Interceptor)
Definition
This heartworm medication can be used as a monthly preventitive. Also effective against hookworms, nematodes, & whipwroms.
Term
Sentinel
Definition
This heartworm preventitive is used as a monthly preventitive that also contains lufenuron for flea control.
Term
Selmectin (Revolution)
Definition
This monthly heartworm preventitive is applied topicaly & absorbed systemically. It also controls fleas, ear mites, & sarcoptic mange. It has some tick preventitive activity.
Term
Moxidectin (PreoHeart-6)
Definition
This six month heartworm medication is an injection that interupts early larval development. It was taken off the market at one point but is now available again.
Term
Adulticides
Definition
These heartworm drugs are used to treat early adult heartworm that may have developed in the right ventricle because of improper or no use of preventitives. Caution should be use when treating dogs with a large # of heartworms because it can cause caval syndrome.
Term
Ectoparasite
Definition

Flies (bots & maggots), grubs, lice, fleas, mites, ticks, & mosquitoes are what type of parasite?

 

Term
Ectoparasiticides
Definition
This type of antiparasidal can be oral, or externally applied through spays, dips, pour-ons, ear tags, spot-ons, shampoos, dusts & foggers. After application, the animal should be monitored for any adverse reactions.
Term
Fenbendazole (Panacur)
Definition
This nenzimidazole antinematodal drug works against nematodes, hook worms, whipworms, taenia, & giardia. Used in small animals, horses, & food animals.
Term
Organophosphates
Definition
This category of antinematodal drugs can cause severe neurologic problems, especially in cats.
Term
Sulfamethoxine (Albon)
Definition
This is the most common drug used for coccidian infestations. Reduces the # of oocytes shed.
Term
Melarsomine (Immiticide)
Definition
This heartworm medication is a arsenical drug given IM in epaxial muscles between L3 and L5.
Term
Cyclosporine (Atopica)
Definition
This immune dehancer drug is one of the most common used for allergies.
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