Term
| Chelation therapy for lead? |
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Definition
DIMERCAPROL and EDTA for adults
SUCCIMER for kids. |
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Term
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Definition
| Chelation therapy for lead in adults |
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Term
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Definition
| Chelation therapy for lead in adults |
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Term
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Definition
| Chelation therapy for lead in children |
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Term
| Chelation therapy for iron? |
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Definition
Desferal - 5-7 doses/week
Exjade - tablet dissolves in fluid to drink
Phlebotomy |
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Term
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Definition
| Iron chelator - 5-7 doses/week |
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Term
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Definition
| Iron chelator - tablet dissolves in fluid to drink |
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Term
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Definition
IV Antifungal. A systemic polyene.
Zygomycosis 1st line.
Cryptococcus Meningitis 1st line with Fluorocytosine.
Eliminated by liver and kidney.
* reduce dose for liver failure
Mech:
At cell membrane, binds to fungal cell membrane ergosterol, forming a pore to lyse cell.
Spectrum: yeasts - molds
Side effects:
nephrotoxic
Infusion related effects- shakes, chills, htn, fever
*Labs - hypokalemia, hypoMg, anemia |
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Term
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Definition
IV or oral Antifungal. Azole.
Mucocutaneous Candidiasis 1st line.
Pulmonary Cryptococcus 1st line.
Eliminated by kidney.
* reduce dose for kidney failure
Mech:
inhibits ergosterol synthesis at fungal cell membrane.
Spectrum:
Narrow.
Yeasts - Candida, cryptococcus, coccidioides.
Few drug interactions. |
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Term
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Definition
IV or oral Antifungal. Azole.
* Aspergillus 1st line
Mucocutaneous Candidiasis 1st line.
Pulmonary Cryptococcus 1st line.
Eliminated by liver Cyp3A4
* don't use by IV if CC <50 ml/min
Mech:
inhibits ergosterol synthesis at fungal cell membrane.
Spectrum:
Yeasts
Some molds: Aspergillus, penicillium
Side effects:
Hallucinations and vision changes
LFT increase |
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Term
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Definition
Oral Antifungal.
Zygomycosis 1st line.
Mucocutaneous Candidiasis 1st line.
Pulmonary Cryptococcus 1st line.
Fecally eliminated. Metabolized by UDP system.
* don't change dose for kidney or liver failure
Interactions: inhibits Cyp34A inhibitor. Many drug interactions.
mech: inhibits ergosterol synthesis at fungal cell membrane.
Spectrum:
Wide.
Yeasts, molds, endemics
Side effects:
LFT increase |
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Term
Echinocandins
includes:
Capsofungin, Micafungin, Anidulafungin |
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Definition
IV Antifungal.
Should not be given alone!
Systemic Candida 1st line.
Aspergillosis 1st line with Voriconazole.
Eliminated by liver.
* reduce dose for liver failure
Mech:
At cell membrane, inhibits glucan-synthetase, which makes the fungal cell wall
Side effects:
increased LFTs
anemia
thrombocytopenia |
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Term
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Definition
Topical or oral Antifungal.
Eliminated by liver and kidney.
* reduce dose for liver or kidney failure
Mech:
inhibits ergosterol synthesis at fungal cell membrane.
Spectrum:
Dermatophytes
Side effects:
Can cause liver failure
GI upset, LFT increase |
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Term
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Definition
Oral Antifungal.
Cryptococcus Meningitis 1st line with Amphotericin B.
Eliminated by kidney.
* reduce dose for kidney failure
Mech:
Inhibits DNA synthesis, 5-FC is converted to 5-FU, a nucleotide that inhibits DNA/RNA synthesis --> cell death
Spectrum:
Yeasts - Candida, Cryptococcus
Some molds
Side effects:
GI upset, LFT increase
*Bone Marrow suppression |
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Term
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Definition
IV Antifungal. A non-systemic polyene.
Mech:
At cell membrane, binds to fungal cell membrane ergosterol, forming a pore to lyse cell.
Sectrum: yeasts - molds |
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