Term
| Definition of Pharmacology |
|
Definition
| Study of biomedical and physiological aspects of drug effects, in Absorption, Distribution, Metabolism, Elimination, toxicity, and specific mechanisms of drug action. |
|
|
Term
| What are the two main areas of Pharmacology? |
|
Definition
| Pharmacokinetics and Pharmacodynamics |
|
|
Term
| What is Pharmacokinetics? |
|
Definition
| This refers to the way the body handles drug ADME. Rational dosage regime is based on this. |
|
|
Term
| What is Pharmacodynamics? |
|
Definition
| The study of biochemical and physiologic effects of drugs and their mechanism of action. |
|
|
Term
| What are the three major routes of drug administration? |
|
Definition
Enteral (GI Tract):
Oral(PO), Sublingual, Rectal(PR)
Parental:
Intravenous(IV), Intramuscular(IM), Subcutaneous(SC)
Others:
Inhalation, Intranasal, Intrathecal/Intraventricular, Topical, Transdermal |
|
|
Term
| Which route of drug administration is most commonly used and easy to access? |
|
Definition
|
|
Term
| Which routes of drug administration go directly to the blood? |
|
Definition
| Sublingual, Intravenous, Inhalation |
|
|
Term
| Which routes of drug administration only go to a local area? |
|
Definition
| Topical, Intramuscular, Subcutaneous |
|
|
Term
| Which route of drug administration is absorbed 50% in the blood and 50% in the liver? |
|
Definition
|
|
Term
| What are the five factors on which the formulation of the drug depends? |
|
Definition
| Barriers, setting, urgency, stability, First Pass Effect |
|
|
Term
| What is the First Pass Effect? |
|
Definition
| The effect of liver metabolism prior to reaching the systemic circulation, when drugs are taken orally or rectally. |
|
|
Term
| By which methods do drugs cross cellular membranes? |
|
Definition
Passive diffusion (high to low concentration).
Active transport (low to high concentration).
Water soluble drugs pass through aqueous channels.
Lipid soluble drugs just move through the membranes. |
|
|
Term
| Is aspirin and other weak acidic drugs better absorbed through the stomach or intestines? |
|
Definition
| Stomach. Due to it's acidic environment. |
|
|
Term
| Are alkaline drugs better absorbed through the stomach or intestines? |
|
Definition
| Small intestine because is has a higher pH. (more alkaline) |
|
|
