Term
| what are the lymphoid WBC neoplasms? |
|
Definition
| Hodgkin Lymphomas, Non Hodgkin lymphoma, leukemia |
|
|
Term
| what are Reed Sternber cells associated with? |
|
Definition
|
|
Term
| what percentage of tumor cells do reed-sternberg cells make up |
|
Definition
|
|
Term
| what are the first and second most common subtypes of hodkin's lymphoma? |
|
Definition
| nodular sclerosis, mixed cellularity |
|
|
Term
| where are the neoplastic cells derived from in hodgkin's lymphoma? |
|
Definition
| germinal center of B cells |
|
|
Term
| what are the symptoms of hodgkin lymphma? |
|
Definition
| painless englargment of lymph nodes |
|
|
Term
| what is the prognosis of hodgkin lymphoma? |
|
Definition
| 90% curable if caught early |
|
|
Term
| what is the typical origin of Non-Hodgkin Lymphoma? |
|
Definition
| B cells (either precursor or peripheral B cell neoplasms) |
|
|
Term
| what are 5 subtypes of non-hodgkin's lymphoma? |
|
Definition
Chronic Lymphocyte leukemia (CLL)
Follicular Lymphoma
Diffuse large B cell lymphoma
mantle cell lymphoma
burkitt lymphoma |
|
|
Term
| which non hodgkin lymphoma has "smudge cells," the bone marrow involved, and hepatosplenomegaly |
|
Definition
| chronic lymphocytic leukemia (CLL) |
|
|
Term
| what is the most common subtype of nonhodgkin lymphoma? |
|
Definition
|
|
Term
| what are 2 cell types in follicular lymphoma and describe them |
|
Definition
centrocytes-small cells w/ irregular nucleus and little cytoplasm
centroblasts-large cells w/ open nuclear chromatin and nuceoli |
|
|
Term
| what nonhodgkin subtype presents w/ rapidly enlarging and symptomatic mass at single nodal or extra nodal site |
|
Definition
diffuse large b cell lymphoma
|
|
|
Term
| what lymphoma is incurable w/ a survival rate of 7-9 years? |
|
Definition
|
|
Term
| What are the two typical presentations at extranodal sites of burkitt syndrome? |
|
Definition
| mandible (endemic) and stomach (sporadic) |
|
|
Term
| what are 2 main types of burkitt lymphoma? |
|
Definition
|
|
Term
| what lymphoma has "starry sky" appearance |
|
Definition
burkitt syndrome
starry sky is numerous beign macrophages w/ ingested nuclear debris |
|
|
Term
| what are 2 subtypes of leukemia? |
|
Definition
| Acute lymphoblastic leukemia and acute myelogenous leukemia (ALL & AML) |
|
|
Term
| what leukemia is more common in children? |
|
Definition
|
|
Term
| what is the ALL composed of? |
|
Definition
| immature lymphoblasts which accumulate in the marrow and suppress normal hematopoeisis |
|
|
Term
| what precentage of cells in marrow must be myeloid blasts in AML |
|
Definition
|
|
Term
|
Definition
|
|
Term
| what are philadelphia chromosomes associated with? |
|
Definition
| myeloproliferative disorder: Chronic myelogenous leukemia (CML) |
|
|
Term
| what type of disorder is multiple myeloma? |
|
Definition
|
|
Term
| how might a patient present for myultiple myeloma |
|
Definition
punched out bone lesions on X rays
increased plasma cells in bone marrow
diffuse plasma cell infilitrate
rouleaux stacking of RBCs in peripheral blood |
|
|
Term
| what is langerhans' cell histocytosis? |
|
Definition
| proliferation of immature dendritic cells w/ vacuolated cytoplasm and vesicular nuclei and birbeck granules in cytoplasm |
|
|
Term
| what type of granules are in Langerhans' Cell histiocytosis? |
|
Definition
|
|
Term
| what type of systems are involved in langerhan's cell histiocytosis |
|
Definition
multisystem that is multifocal or unifocal
unisystem that is multifocal |
|
|
Term
| what would cutaneous lesions in toddlers and babiesss represent? |
|
Definition
| multifocal, multisystem, langerhan's cell histiocytosis? |
|
|
Term
| what is involved in multisystem, unifocal, langerhan's cell histiocytosis? |
|
Definition
| skeletal system of older children and teens |
|
|
