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Vitamins and Minerals
Deficiency, Toxicity, Names, and Interrelations
81
Science
Undergraduate 3
05/03/2012

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Term
Vitamin
Definition
Organic compound required in small amounts by an organism
Term
Thiamin
Definition
B1
Food Sources: Lean Pork, Legumes, Whole grains, Brewer's yeast
Required for alcohol oxidation
Term
Inhibits Thiamin
Definition
Alcohol, Folate Def, Protein Def
Term
Thiamin Def
Definition
Beriberi
Term
Wernicke-Korsakoff Syndrome
Definition
Form of Beriberi
Major cause is ETOH
Term
Thiamin Tox
Definition
No evidence
Term
Riboflavin
Definition
Yellow color, destroyed by exposure to light
Sources: Dairy, eggs, meat, enriched breads and cereals
Term
Riboflavin Def
Definition
Occurs in combo with other BVit Def
ANGULAR DERMATITIS
Term
Riboflavin Tox
Definition
Not seen in humans
Term
Niacin
Definition
B3
Sources: Whole grain bread and cereal, milk, eggs, meat, dark veggies
Term
Niacin Def
Definition
Pellegra
4Ds - Dermatitis, Diarrhea, Dementia, Death
Casal's necklace - symmetric
Term
Niacin Tox
Definition
Flushing
Term
Pyridoxine
Definition
B6
Sources: Meats, cereals, legumes, lentils, nuts, fruits, veggies
Term
Pyridoxine Def
Definition
Rare
Characterized by weakness, irritability, nervousness, insomnia, difficulty walking
Term
Pyridoxine Tox
Definition
Loss of fine motor skills and ataxia
Term
Panthothenic Acid
Definition
Found is basically all foods
Sources: Organ meats, mushrooms, avocados, broccoli, whole grains
Term
Panthothenic Acid Def/Tox
Definition
No evidence for either
Term
Biotin
Definition
Present in all living cells
Biotinidase frees biotin from protein bound form biocytin (biotin + leucine)
Term
Biotin Def/Tox
Definition
Seen only in genetically def biotinidase
No Tox
Term
Folic Acid
Definition
Folate
Sources: Meats, fruits, veg (asparagus), dry beans, peas, nuts, whole grains
Term
Folic Acid Def
Definition
Dermatitis, impaired growth
Megaloblastic Anemia
Neural Tube Defects - spina bifida and anencephaly
Term
Folic Acid Tox
Definition
Overconsumption masks B12 def
Term
Cyanocobalamin
Definition
B12
Foods of animal origin
Must be bound to protein for abs
Term
Folate/B12 Function
Definition
B12 With folate, makes homocysteine into methionine
And can go other way
Term
B12 Def/Tox
Definition
Pernicious Anemia (megaloblastic)
No Tox
Term
Ascorbic Acid
Definition
Vit C
Sources: Citrus, Strawberries, Melons, Cabbage, Brussels Sprouts, Broccoli, Cauliflower
Term
Vit C Function
Definition
Antioxidant
Protects Vit E
Term
Vit C Def
Definition
Scurvy

Relating to Iron/Folate:
Fatigue, malaise, anemia
Term
Vit C - Collagen
Definition
Critical for collagen production
1st sign of Def - impaired wound healing, joint pain, bone changes in infants, bleeding gums
Term
Vit C Tox
Definition
May increase kidney stones through increased oxalate formation
Term
Vit A
Definition
Retinol/Carotene
Retinol Sources - Red meat, liver, whole milk, cheese, butter
Carotene sources - squash, carrots, peas, peaches, apricots
Term
Vit A Def
Definition
Keratinization: drying and hardening of epithelium of eye
Xerophthalmia: all eye problems d/t vitamin A deficiency
Term
Vit A Tox
Definition
Hypervitaminosis A
Hypercarotenosis (yellow-colored skin)
Term
Cholecalciferol
Definition
Vit D
Cod liver oil and fortification in milk
Sunlight
Term
Cholecalciferol converted to...
Definition
Must be converted to 25OH Vit D in liver (this is one in blood)
Which must be activated in kidney to 1,25OH Vit D
Term
Vit D and PTH
Definition
PTH: Pulls Ca from bone
1,25OH Vit D: Deposits Ca into bone
Term
Vit D Def
Definition
Rickets in children
Term
Vit D Tox
Definition
Calcification of soft tissues
Term
Vit E
Definition
Tocopherol
Plant oils
Term
Vit E Functions
Definition
Antioxidant
Term
Vit E Def
Definition
Seen only in animals
Term
Vit E Tox
Definition
Megadoses may interfere with other Fat Sol Vit
Term
Vit K
Definition
Menaquinione
Green leafy veggies
Term
Vit K function
Definition
Blood clotting
-Shot given at birth
Bone formation
Term
Vit K Def/Tox
Definition
N/A
Term
Heme Iron
Definition
Well-absorbed
Meat, esp. red meat
Term
Nonheme Iron
Definition
Not well-absorbed
Legumes, raisins, prunes, molasses, fortified cereals, cooking in iron skillets
Term
Inhibits Fe Abs
Definition
Tannins, soy proteins, phytates (type of fiber), Ca, Zn, Mn
Term
Increases Fe Abs
Definition
Vit C, fructose, citric acid, stearic acid, HPro Foods
Term
Ferritin
Definition
Storage form of iron
Term
Transferrin
Definition
Transport form of iron
Term
Hemoglobin
Definition
75% of Fe in blood as hemoglobin
Binds O2 for transport in blood
Term
Myoglobin
Definition
Muscle protein that binds O2 for use
Term
Fe Def
Definition
Anemia - Microcytic
Most common nutritional def in world
Term
Fe Tox
Definition
Hemochromatosis
Term
Calcium Sources
Definition
Dairy
Nuts
Whole Grains
Term
Osteoblasts
Definition
Create bone
Term
Osteoclasts
Definition
Bone resorption
Term
Ca Def
Definition
Osteoporosis
>2.5 SD
Osteopenia
Between 1 and 2.5 SD
Term
Ca Tox
Definition
Hypercalcemia - Only supplements
Kidney Stones
Term
Phosphorus Sources
Definition
Milk and Dairy, Meat, Legumes, Colas (except Root Beer), Whole grains
Term
Phosphorus Def
Definition
Hypophosphatemia
Refeeding Syndrome
Osteomalacia
Muscle atrophy and weakness
Term
Phosphorus Tox
Definition
Mineralization of soft tissues
Term
Magnesium Sources
Definition
Whole grains, nuts, green veggies
Term
Zinc Sources
Definition
Oysters, Crab, Meat, Poultry, Milk, Nuts, Beans
Term
Zinc Functions
Definition
Structure of Proteins - Zinc Finger
Term
Zinc Def
Definition
Dwarfism
Hypogonadism
Rough skin
Term
Zinc Tox
Definition
Can interfere with Cu metabolism
Term
Copper Sources
Definition
Liver, oysters, clams, crabs, nuts, seeds, legumes
Term
Copper Def
Definition
Uncommon, anemia unresponsive to Fe Supp
Term
Menkes Steely Hair Disease
Menkes Syndrome
Definition
Intestinal cells absorb Cu but does not release into circulation
Term
Wilson Disease
Definition
Normal Cu absorption but low excretion into bile
Term
Copper Tox
Definition
Usually due to contamination of foods, water
Term
Selenium Sources
Definition
Brazil Nuts, seafood, whole grains, organ meats
Term
Selenium content heavily dependent on what?
Definition
Soil content
Term
Selenium function
Definition
Glutathione peroxidase
Term
Selenium Def
Definition
Noted in LT TPN patients, PKU diets
1979 - Keshan disease is Se-Def China
Term
Selenium Tox
Definition
Many symptoms, Garlic odor on breath is notable
Term
Iodine Sources
Definition
Iodized salt, seaweed, fish and shellfish, milk, potato
Term
Thyroid Problems
Definition
Hypothyroidism: decreased resting metabolic rate
Hyperthyroidism: increased RMR
Term
Iodine Def
Definition
Most common preventable cause of brain damage
Goiter
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