Term
| This drug can cause Crystalline Nephropathy. Rare cases can cause delirium, tremors and seizures |
|
Definition
|
|
Term
| High doses of this drug you can see confusion, hallucinations and seizures |
|
Definition
|
|
Term
| In HIV patients can see Thrombotic thrombocytopenic purpura and hemolytic uremia |
|
Definition
|
|
Term
| This drug can cause mammary adenocarcinoma in females |
|
Definition
| Famicyclovir (Fam- No families due to adenocarcinoma in females) |
|
|
Term
| Drug is ONLY used topically because it can NOT tell the difference between host and virus. |
|
Definition
|
|
Term
| Used in acyclovir resistant HSV infection |
|
Definition
|
|
Term
| This drug requires activation by triphosphorylation before inhibiting DNA polymerase. The Initial phosphorylation is catalyzed by viral UL97 (CMV protein kinase) |
|
Definition
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|
Term
|
Definition
Efavirenz
Probenecid
Trimethoprim
Ganciclovir
Maraviroc (Inhibits CCR5 causing DECREASED immune surveillance)
Delaviridine
Protease Inhibitors
Azoles
Clarithromycin |
|
|
Term
|
Definition
Efavirenz (Self-Inducer)
Etravirine
Rifampin
Carbamazepine
Phenytoin
St. Johns Wort |
|
|
Term
| Drug is sued in Kidney, Heart and Pancreas transplant patients for CMV |
|
Definition
| Valganciclovir (pro-drug of ganciclovir) |
|
|
Term
| This drug is effective against CMV and HSV drug resistant strains |
|
Definition
|
|
Term
| Does NOT rqeuire Phosphorylation and blocks pyrophosphate binding. Inhibits cleavage of pyrophosphate with deoxynucleoside triphosphate |
|
Definition
|
|
Term
Can Cause SIGNIFICANT Renal impairments and complete electrolyte imbalance
Hypocalcemia due to Calcium chelation
Genital Ulceration
CNS Toxicity : Hallucination, HA, Seizures |
|
Definition
|
|
Term
| Potent Chain terminator and DNA synthesis inhibitor, Acts as alternative substrate for viral DNA polymerase |
|
Definition
|
|
Term
| Cidovir and Acyclovir resistant strains can have cross-resistance for this drug |
|
Definition
|
|
Term
| Can see Adenocarcinoma, Mutagenic, Embryotoxic and Renal toxicity with this drug |
|
Definition
|
|
Term
| Cytosine Nucleotide analog |
|
Definition
|
|
Term
| Synthetic 36 AA peptide fusion inhibitor. (Gp41 Antagonist) |
|
Definition
| Enfuvirtide (Sounds like infusion [Enfu]) |
|
|
Term
| Binds to GP41 subunit of viral glycoprotein preventing onformation change that prevents host cell membrane fusion with virla membrane. |
|
Definition
|
|
Term
| CCR5 Antagonist, blocks interactions between CCR5 and gp120. Binds selectively and specifically to chemokine receptorCCR5 needed for entry of HIV into CD4 |
|
Definition
|
|
Term
| Only used when adults with CCR5-tropic HIV-1 infection is expressing virologic failure due to resistance to other antiretroviral |
|
Definition
|
|
Term
Adverse effects of this drug can cause:
Postural Hypotension
Cough
Eosinophilia or Elevated IgE
MI and Infarction |
|
Definition
|
|
Term
|
Definition
Abacavir
Didanosine
Zidovudine
Emitricitabine
Tenofovir
Stravudine
(AT ZEDS - Mnemonic) |
|
|
Term
| Drug class works by Competitively inhibiting HIV reverse transcriptase. It is incorporated into the growing viral DNA to cause premature chain termination by inhibition of binding with incoming nucelotides |
|
Definition
| Nucleoside reverse transcriptase Inhibitors (NRTI) |
|
|
Term
| NRTI That is a Guanosine Analog |
|
Definition
|
|
Term
| NRTI that is a Deoxyadenosine Analog |
|
Definition
|
|
Term
| Usually given with a buffer formulation to prevent inactivation for the drug |
|
Definition
|
|
Term
| Effective in AZT resistant patients |
|
Definition
|
|
Term
Can Cause :
Dose-dependent Pancreatitis
Cardiomyopathy
Asymptomatic Hyperuricemia and cause gout attacks |
|
Definition
|
|
Term
| Tetracyclines and FQs should be given at LEAST 2 hours before or after which NRTI? |
|
Definition
|
|
Term
| NRTI that is a Deoxythymidine analog |
|
Definition
|
|
Term
| This drug should NEVER be administered alone for treatment of HIV due to quick generation of resistant HIV strains |
|
Definition
|
|
Term
Can cause:
Myelosuppression resulting in macrocytic anemia
Orneutropenia
Lipoatrophy |
|
Definition
|
|
Term
| Known to cause hyperpigmentation of palms or soles, especially in black people |
|
Definition
|
|
Term
| Drug is formulated with lactose so it can cause lactose intolerance |
|
Definition
|
|
Term
| Causes proximal renal tubulopathy, excessive renal phosphate and calcium losses and 1-hydroxylation defects of vitamin D |
|
Definition
|
|
Term
Dose related Peripheral sensory neuropathy
Elevation in aminotransferases
Lactic Acidosis with hepatic steatosis and lipodystrophy |
|
Definition
|
|
Term
Used against Zidovudine sensitive and resistant HIV-1 strain.
Used synergistically with zidovudine and Stavudine |
|
Definition
|
|
Term
| Inconvenient NRTI due to its three times daily dosing and serious adverse effects |
|
Definition
|
|
Term
Can cause Fluminant, Life-threatening hepatitis
Rash with a maculopapular eruption normally |
|
Definition
|
|
Term
| Bioavailability is reduced by H2 blockers or antacids |
|
Definition
Delavirdine and Atazanavir (PTI) and Indinavir
Mnemonic (AID) - Don't take with any aids |
|
|
Term
| This PI does NOT cause dyslipidemia, fat redistribution or metabolic syndrome like the other PI's |
|
Definition
|
|
Term
If given with a CB can cause AV block and AT prolongation.
Can also cause Nephrolithiasis |
|
Definition
Atazanavir
Infinavir can cause Nephrolithiasis |
|
|
Term
| Should monitor theophylline and digoxin when given with this drug |
|
Definition
|
|
Term
|
Definition
Atazanavir
Ritonavir
Saquinavir
Indinavir
Nelfinavir
Fosamprenavir
Lopinavir
Darunavir
Mnemonic (Lard Fins) |
|
|
Term
| Contraindicated with Saquinavir due to QT prolongation |
|
Definition
|
|
Term
| This is the LEAST effective PI due to its poor bioavailability |
|
Definition
|
|
Term
| PI that can cause depression |
|
Definition
|
|
Term
| Formulated with Ritonavir to increaes serum concentrations |
|
Definition
|
|
Term
| Drug that MUST be given with Ritonavir in patients resistant to other PI's |
|
Definition
|
|
Term
| Should NOT be used in sulfonamide allergies |
|
Definition
|
|
Term
| Inhibits integrase and replication of HIV-1/2. |
|
Definition
|
|
Term
| Normally only used when HIV patient is resistant to other drugs such as NRTI, NNRTI and Protease inhibitors |
|
Definition
|
|
Term
|
Definition
Efavirenz
Nevirapine
Delavirdine
Mnemonic (NED) (Zed's brother [NRTI] Ned) |
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