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Virulence Factors
Description
16
Microbiology
Professional
07/21/2012

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Cards

Term
M-protein (4)
Definition
1) Adherence factor
2) Anti-phagocytic
3) Antigenic (leads to antibodies)
Term
Lipoteichoic acid (1)
Definition
1) Adherence factor
Term
Streptokinase
Definition
Activates plasmin to dissolve clots to facilitate spread
Term
Hyaluronidase
Definition
Breaks through connective tissue/proteoglycans
Term
Streptococcus pyrogenic toxin
Definition
Activates the mediators of sepsis, such as IL-1
Term
Streptolysin O
Definition
Heat labile

Lyses RBC's
Term
Streptolysin S
Definition
Heat Stabile

Lyses RBC's
Term
Hemolysin
Definition
Lyses RBC's
Term
Protein A
Definition
Binds IgG, preventing phagocytosis
Term
Coagulase
Definition
Allows fibrin formation around organism
Term
Staphylokinase
Definition
Lyses formed clots
Term
Tetanospasm toxin
Definition
Inhibits release of GABA and glycine inhibitory neurotransmitters
Term
C. perfringens: Alpha toxin- lecithinase
Definition
Splits lecithin in phosphocholine and diglycerides
Term
C. botulinum neurotoxin
Definition
Inhibits acetylcholine release
Term
C. diphtheriae exotoxin
Definition
1) A-subunit: blocks eukaryotic protein synthesis by inactivating EF2
2) B-subunit: provides entry into cardiac and neural tissues
Term
Listeriolysin O and phospholipase
Definition
Allows escape from phagolysosome
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