Term
| infections associated with EBV |
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Definition
| Infectious mononucleosis, oral hairy leukoplakie, Burkitt's lymphoma, Lymphoblastic leukemia, Nasopharyngeal carcinoma, some gastric & smooth muscle tumors, multiple sclerosis pts exhibit heightened antibody response to EBV |
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Term
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Definition
"Kissing disease"
Dev. 4-6 wks after exposure |
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Term
| Clinical features of infectious mononucleosis |
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Definition
| Severe fatigue, low grade fever, eye pain, swelling of eyelids, lymphadenopathy |
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Term
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Definition
| Maculopapular rash, urticaria, petechiae |
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Term
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Definition
| Acute gingivitis, ANUG, stomatitis, RAU like ulcers, palatal petechiae |
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Term
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Definition
Monospot (Horner), Monosticon (Organon) or immunofluorescent serological testing
CBC and differntial lymphocytosis w/ "atypical lymphocytes" |
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Term
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Definition
Heterophile antibodies
Serum IgG anti-EBV capsid indicates past or present EBV infection
Serum IgM anti-EBV capsid indicates current infection
EBV early antigens indicate early or chronic EBV disease |
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Term
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Definition
Bed rest, NSAIDs, intravenous hydration, high dose steroids in some cases
4-6 wks recovery
Risk of splenic rupture, EBV hepatitis, Bell's palsy |
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Term
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Definition
| Good, risk of B cell proliferation |
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Term
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Definition
Immunosuppressed, HIV negative
Transplants
Cytotoxic therapy for leukemia
Lymphoma
Myelodysplastic syndrome |
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Term
| Oral hairy leukoplakia treatment |
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Definition
Antifungal
Palliative
Antiviral
Surgical excision |
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Term
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Definition
HHV type 5 "salivary gland virus"
Stillborns, immunosuppressed, HIV-retinitis
Saliva can be used to screen newborns |
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Term
| Histology of cytomegalovirus |
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Definition
| Endothelial cells, salivary gland ductal epithelial cells |
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Term
| Treatment of cytomegalovirus |
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Definition
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Term
| Oral manifestations in cytomegalovirus |
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Definition
Multiple, shallow ulcers
Lips, tongue, pharynx, buccal mucosa
May resemble herpetic stomatitis
40% infected neonates have enamel hypoplasia |
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Term
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Definition
Single stranded, unencapsulated ribonucleic acid (RNA)
Cause exanthem (gen skin lesions) and/or enanthem (oral mucosal lesions)
Occurs in late summer, early fall
Assoc w/ crowded living conditions/poor hygiene |
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Term
| Significantly painful oral lesions in Enteroviruses occur in: |
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Definition
Herpangina
Hand, food & mouth disease
Lymphonodular pharyngitis
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Term
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Definition
| Coxsackie viruses of both A and B groups, contagious |
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Term
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Definition
| Primarily in children - vesicles are located primarily on soft palateand tonsillar pillars. Vesicles are usually clustered. Oropharynx is painful and erythematous. Ulcers form when vesicles rupture after 3-4 days. |
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Term
| Clinical features of Herpangina |
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Definition
| Fever, malaise, lymphadenopathy, headache, sore throat |
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Term
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Definition
| intraepithelial vesicles w/ ballooning degernation of epithelial cells |
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Term
| Differential diagnosis of Herpangina |
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Definition
| HSV, HVZ when vesicles present, RAU when uclers present, limitation to soft palate/tonsillar pillars is virtually diagnostic, virus may be detected and cultured from stool specimens |
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Term
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Definition
| Palliative oral rinses, soft diet, antipyretics |
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Term
| Hand, foot, and mouth disease caused by... |
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Definition
| Group A Coxsackie virus of enterovirus group, mildly contagious |
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Term
| Characteristics of HF&M disease |
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Definition
Mostly occurs in school age children
Vesicular eruptions of hands, mouth, and feet are pathognomonic |
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Term
| Oral associations of HF&M disease |
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Definition
| Vesicles w/ red halo located on lips and buccal mucosa, usually sparing oropharynx, rupture in 24-28 hrs leaving erosions or ulcers with a pseudomembrane |
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Term
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Definition
below kneeds and elbows, vesicular w/ circumferential erythema, dorsal and ventral surfaces
All lesions painful, fever, malaise, lymphadenopathy |
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Term
| Differential diagnosis of HF&M disease |
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Definition
| HSV, HVZ, herpangina, RAU, virus may be cultured from stool specimen |
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Term
| Treatment of HF&M disease |
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Definition
| Antipyretic-analgesics, soft or liquid diet, fluids, palliative mouthwash, viscous lidocaine |
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Term
| Causative agent of Acute Lymphonodular Pharyngitis |
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Definition
| Coxsackie virus A10 (Genus enterovirus, RNA virus) |
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Term
| Clinical features of ALP (acute lymphonodular pharyngitis) |
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Definition
Occurs primarily in children
Fever, headache, sore throat
Raised, discrete white/yellow nodules on pharynx, tonsillar pillars and soft palate
No vesicles or ulcerations dev
Usually resovle in 7-10 days |
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Term
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Definition
Clinical presentation
May be confirmed w/ detection of elevation of neutralizing antibodies between acute and convalescent serum determinants |
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Term
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Definition
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Term
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Definition
| Excellent, sequelae are rare |
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Term
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Definition
| Seroconversion (may take several weeks) |
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Term
| Signs of Primary HIV infection |
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Definition
3-6 weeks after exposure
Seroconversion follows
fever, skin rash
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Term
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Definition
related complex - malaise, night sweats, weight loss, diarrhea, generalized lymphadenopathy, CD4 cells (T cells)
Opportunistic infections, cancers, encephalitis, death |
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Term
| Oral signs of primary HIV infection |
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Definition
| Erythema, erosions, ulcerations, oral/esophageal candidiasis |
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Term
| Pathogenesis of oral signs that develop at the end of HIV+, asymptomatic stage: |
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Definition
CD4 lymphocyte depletion
Loss of Langerhan cells
Severely imparied cell-mediated immunity
Humoral dysregulation Phagocytic cell defects |
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Term
| Oral signs that dev at end of HIV+, asymptomatic stage: |
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Definition
Fungal
Viral
Bacteiral
Autoimmine/idioplastic
Neoplastic |
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Term
| Oral signs that develop at the end of the HIV+, asymptomatic stage: Fungal - |
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Definition
Oral candidiasis (pseudomembranous, erythematous, atrophic, angular cheilitis)
Histoplasmosis
Cryptococcosis |
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Term
| Oral signs that dev at end of HIV+, asymptomatic stage: Bacterial - |
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Definition
Perio disease (linear gingival erythema, necrotising ulcerative gingivitis)
Necrotising ulcerative periodontitis
Tuberculosis
Mycobacterium avium complex |
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Term
| Oral signs that dev end of HIV+, asymptomatic stage: viral - |
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Definition
Herpes simplex: primary, recurrent labialis, recurrent intraoral
Herpes zoster
Cytomegalovirus ulcers
Hairy leukoplakia
Human papillomavirus assoc w/ lesions
Molluscum contagiosum (skin/lips usually) |
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Term
| Oral signs dev at end of HIV+, asymptomatic stage: Autoimmune/idiopathic - |
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Definition
Recurrent aphthous ulcers (atypical ulceration)
Salivary gland disaese (xerostomia, swelling etc)
Sjogrens syndrome-like illness, diffuse infiltrative lymphocytosis syndrome (DILS)
Immune thrombocytopenia
Melanosis |
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Term
| Diffuse infiltrative lymphocytosis syndrome is associated with which disease? |
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Definition
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Term
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Definition
| Sjogrens syndrome-like illness |
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Term
| HIV salivary gland changes |
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Definition
HIV-associated parotid lymphoepithelial cysts
Sjogren's syndrome-like illness w/ AIDS (DILS) |
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Term
| Clinical features of DILS |
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Definition
Generalized lymphadenopathy
Dry eyes, dry mouth
Arthralgia
Biopsy of salivary glands -> intense lymphocytic infiltrate |
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Term
| Oral signs that dev at end of HIV+, asymptomatic stage: Neoplastic - |
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Definition
Kaposi's sarcoma
Non-Hodgkin lymphoma
Melanoma
Oral squamous cell carcinoma? |
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Term
| Diagnosis of HIV (physicians) |
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Definition
| Viral antibodies, viral antigens, viral RNA/DNA, culture |
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Term
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Definition
Reduces HIV production 99.7% from primary CD4+ cells
Works by binding Tat viral protein which activated HIV gene expression, stopping viral replication |
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Term
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Definition
| Paromyxovirus Morbillivirus |
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Term
| Clinical features of Measles |
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Definition
Causes rash-vaculitis, brownish as rash fades then desquamates
Enlarged lymphoid tissue including Peyer's patches
Runny nose, cough, conjunctivitis, fever, abdominal pain
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Term
| Main oral feature of Measles (Rubeola) |
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Definition
| Koplick's spots intraoral |
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Term
| Oral manifestations associated with Measles |
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Definition
Candidiasis
NUG
Necrotizing stomatitis
Enlarged oral and tonsillar lymphoid tissue
Pitting of teeth due to enamel hypoplasia |
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Term
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Definition
| Lymphoid hyperplasia w/ Warthin-Finkeldy multinucleated giant cell |
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Term
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Definition
Usually clinical features and history
Lab confirmation done in atypical cases
Viral culture
Rising antibody titers |
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Term
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Definition
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Term
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Definition
| Fluids, nonaspirin antipyretics; if immunocompromised - ribaviran, immunoglobulin, interferon, Vitamin A |
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Term
| Complications associated with Measles |
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Definition
| 21% rate: otitis media, pneumonia, bronchitis, diarrhea, acute appendicitis, encephalitis, fatal if immunocompromised |
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Term
| Rubella causative agent.. |
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Definition
| Rubella virus (Togavirus family) |
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Term
| Clinical features of Rubella (german measles) |
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Definition
Mild viral infection - rash, asymptomatic, self-limiting
NO oral manifestations |
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Term
| Diagnosis, treatment, prevention of Rubella |
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Definition
Clinical & history
No treatment
Excellent
MMR vaccine |
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Term
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Definition
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Term
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Definition
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Term
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Definition
| Paramyxovirus Rubulavirus |
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Term
|
Definition
| saliva, respiratory droplets, or urine |
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Term
| Clinical features of Mumps |
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Definition
Fever, headache, malaise, anorexia
Affects exocrine glands (parotids and submandibular)
30% subclinical
Affects bilateral or unilateral (25%) |
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Term
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Definition
Clinical presentation when community outbreaks
Isolated cases specific IgM or IgG |
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Term
| another name for Fifth disease |
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Definition
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Term
| Causative agent of Fifth disease |
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Definition
| Parvovirus B19, spread by aerosolized secretions |
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Term
| How many stages are experienced w/ Fifth disease? |
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Definition
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Term
| Stage 1 of Fifth disease: |
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Definition
| Rash begins w/ abrupt onset of bright erythema on cheeks "slapped face appearance" |
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Term
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Definition
| Maculopapular rash develops on trunk and extremities |
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Term
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Definition
| Rash fades and leaves a lacelike pattern w/ central clearing |
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Term
| Actions of Parvovirus B19 |
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Definition
| fetal anemia by reducing erythropoiesis. Virus is most common cause of aplastic crisis in children and adults with chronic hemolytic anemia, such as sickle cell, spherocytosis, or thalassemia. |
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