Term
|
Definition
|
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Term
|
Definition
infectious hep- acute viral
fecal-oral route
vaccine
self-limiting |
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Term
| high risk populations for Hep A |
|
Definition
kids
close contact
MSM
travelers
preggers
IDUs
work w/primates |
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Term
|
Definition
incubation-asymptomatic
preicteric-no appetite, n/v, fever
icteric-jaundice, incr bilirubin, dark urine, light stool |
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Term
|
Definition
Havrix
Vaqta
Twinrix- Hep A & B. not for kids. |
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Term
|
Definition
|
|
Term
|
Definition
give to <12months old
post expose prophy for >40 yrs old
allergic to Hep A vaccine
chronic liver disease |
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Term
|
Definition
passive immunity
give during incubation period
interact with live vaccines -MMR and Varicella |
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Term
|
Definition
most serious Hep
blood born
causes chronic liver disease and can lead to cirrhosis and liver cancer |
|
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Term
|
Definition
most serious Hep
blood born
causes chronic liver disease and can lead to cirrhosis and liver cancer |
|
|
Term
|
Definition
anxiety, malaise
ascites, variceal bleeds, jaundice
hepatic encephalopathy
vomiting, seizure |
|
|
Term
|
Definition
inactivates
Recombivax HB
Engerix-B
Twinrix- Hep B & A
Comvax- dTAP, Hep B, HIB- peds
Pediarix-dTap,HepB, polio
Hbig-hyper Hep B, Nabi-HB- post exposure prophy or prevent after liver tx |
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|
Term
| Hep B vaccine schedule- single antigen |
|
Definition
1mL at 0, 1,6 months
1st dose within 24 hours of birth |
|
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Term
|
Definition
Interferon (IFN-alpha2b)
lamivudine
telbivudine
adefovir
entecaviir
pegylated IFN-alpha2a
tenofovir |
|
|
Term
|
Definition
peginterferin alpha2a
Hep B tx
combo more effective |
|
|
Term
|
Definition
lamivudine
Hep B tx
nucleoside reverse transciptase inhibitor (NRTI) |
|
|
Term
|
Definition
adefovir
NRTI
Hep B tx
1 yr tx
combo w/lamivudine
nephrotixicity possible |
|
|
Term
|
Definition
entecavir
NRTI
Hep B tx
tx-1yr or lifelong if decompensated liver disease
next after lamivudine fail |
|
|
Term
|
Definition
telbivudine
Hap B tx
NRTI
tx-1 yr
documented resistance |
|
|
Term
|
Definition
tenofovir
NRTI
Hep B tx
1st line tx
less resistance than others
tx 1 yr or life long. |
|
|
Term
|
Definition
Emtricitabine- indicated in HIV tx
combo therapy for pts w/antiviral resistant HBV |
|
|
Term
|
Definition
most common bloodborne pathogen
ssRNA virus
acute infection leads to chronic in most cases
progression to chronic over 20-30yrs |
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Term
|
Definition
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Term
|
Definition
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Term
| hep C high risk populations |
|
Definition
IDUs (current/past)
HIV infection
blood/organ transplant b4 1992
receive clotting factors b4 1987
hemodialysis
unexplained high ALT levels, liver dx
healthcare workers post needle stick
child born to Hep C mother
sex partners of Hep C pts |
|
|
Term
|
Definition
Interferons
Ribavirin
Boceprevir(victrelis)
Telaprevir(incivek) |
|
|
Term
|
Definition
taribavirin- prodrug of ribavirin
long acting interferons- albuferon
protease inhibitors
polymerase inhibitors |
|
|
Term
|
Definition
|
|
Term
|
Definition
contraindicated to ribavirin
and risk factor for hep C |
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