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Veterinary Virology
DNA viruses
21
Microbiology
Professional
03/25/2012

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Term
Poxviridae
Definition
capsid-complex
enveloped
replication-cytoplasmic
genome-linear dsDNA
size- THE LARGEST = 250-300nm
Genus:
1.orthopoxvirus: cowpox and small pox
2.parapoxvirus: pseudcowpox, bovine paplar stomatitus and orf
3.capripoxvirus: sheeppox, goatpox and lumpy skin disease (Notifiable)
4.avipoxvirus: fowlpox and canarypox
5.lepripoxvirus: myxoma (N)
6.suipoxvirus: swinepox
Host range:usually specific except cowpox = broad range
Pathogenesis:skin, respiratory or mechanical (papule->vesicle->pustule->scab)
Term
Iridoviridae
Definition
capsid- icosahedral
enveloped
replication-cytoplasmic
genome-linear dsDNA
size- large
* produces iridescent tumors
Host range: fish, insects and amphibians
Disease = lymphcystis in fish
Term
Asfarviridae
Definition
capsid-icosahedral
enveloped
replication-cytoplasmic
genome-linear dsDNA
size-200nm
genome:only the one = African Swine Fever (N)
Host range:pigs and ticks *only true arbovirus (transmitted by arthropods)
Pathogenesis: mechanical, ingestion and respiratory
Term
Herpesviridae
Definition
capsid-icosahedral
enveloped
replication-nucleus
genome-linear dsDNA
size-100nm
* known for latency
Subfamilies:
1.alphaherpesvirinae
2.betaherpesvirinae
3.gammaherpesvirinae
host range: broad
pathogenesis:mucosal surfaces and respiratory
Term
Adenoviridae
Definition
capsid-icosahedral
non-enveloped
replication-nucleus
genome-linear dsDNA
size:70-80nm
genome:
1.mastadenovirus
2.aviadenovirus
3.atadenovirus
4.siadenovirus
host range: broad
pathogenesis: nasal, oral or conjunctival exposure
Term
papillomaviridae
Definition
capsid-icosahedral
non-enveloped
replication-nucleus
genome-circular dsDNA
size-55nm
genome: 16 total (alpha-pi)
Host range: specific with a few exceptions
Pathogenesis:usually in young animals, direct contact or via fomites. Requires skin abrasions for entry.
*spontaneously regresses, can become malignant
horses: usually around the lips and muzzle, infected via other horses or biting flies. Exception = sarcoids locally invasive infection via BPV-1 or 2.
Cows:seen when feeding on bracken. Occurs on teats as well (BPV 2 & 5)
Dogs: oral papillomas
Term
Polyomaviridae
Definition
capsid-icosahedral
non-enveloped
replication-nucleus
genome-circular dsDNA
size-small
genome:only 2 viruses = mouse polyoma virus and simian virus 40 (SV40)
*generally non-pathogenic except:
1.budgerigar fledgling disease
2.bovine polyomavirus
Term
Parvoviridae
Definition
capsid-icosahedral
non-enveloped
replication-nucleus
genome-linear ssDNA
size-very small (18-25nm)
Sub-families:
1.parvovirinae
a.parvovirus
b.erythrovirus
c.dependovirus
2.densovirinae
host range: specific but broad
pathogenesis: ingestion or respiratory
* 5 classical clinical symptoms:
a.diarrhoea
b.immunsuppression
c.reproductive failure
d.cerebellar hypoplasia (only in cats)
e.myocarditis
*requires activly dividing cells for growth
Term
Herpesviridae (classification)
Definition
1.Alphaherpesvirinae
a.simplexvirus: BoHV-2,HHV 1&2
b.Varicellovirus: EHV-1&4, BoHV-1&5, goat HV, SHV-1, CHV, FHV, Deer HV-1&2, HHV-3
c.Mardivirus: GHV-2&3, turkey HV
d.Iltovirus: GHV-1
2.betaherpesvirinae
a.cytmegalovirus:HHV-5
b.Muromegalovirus:
c.Roseolovirus
3.gammaherpesvirinae
a.Lymphocryptovirus:HHV-4
b.Rhadinovirus: EHV-2&5, BoHV-4, Alcelaphine HV-1&2, OHV-2, HHV-8
Term
Herpesviridae (Disease-Horse)
Definition
1.EHV-1: abortion, perinatel moratality, encephalomyelitis and respiratory disease
2.EHV-3: (Equine coital exanthema) = genital lesions
3. EHV-4: (Equine Rhinopneumonitis)= respiratory disease
4. EHV-2&5: non-pathogenic
Term
Herpesviridae (Disease-cows)
Definition
1.BoHV-1:bovine rhinotracheitis (IBR), infectious pustular vulvovaginitis(IPV), abortion,GIT disease in calves (IRBD) and keratoconjuctivitis.
2. BoHV-2:bovine herpes mammillitus, dermatopathic herpes and pseudo-lumpy skin
3.BoHV-4:many effects, not proven
4.BoHV-5: Bovine herpes encephalitis
5. Alcelaphine-1&2: Malignant Catarrhal Fever (ALSO OHV-2 in sheep)
Term
Herpesviridae (Disease-Pigs)
Definition
1.SHV-1: Aujezky's disease "pseudo-rabies"
2. SHV-2:Porcine cytomegalovirus (PCMV), Inclusion body rhinitis (IBRV)
Term
Herpesviridae (Disease-Goats)
Definition
caprine Hv-1: possible abortion or vulvovaginitis, not widely reported
Term
Herpesviridae (Disease-Dog)
Definition
CHV-1: "fading puppy syndrome"
* grows only in low body temperatures,
infected via respiratory = fatal to puppies
Term
Herpesviridae (Disease-Cat)
Definition
FHV-1: Feline viral rhinotracheitis (FVRV) via respiratory infection, can also cause abortion, vegninitis and placentitis
Term
Herpesviridae (Disease-Poultry)
Definition
1. GHV-1: infectious laryngotracheitis via respiratory infection
2. GHv-2&3: Merek's disease
a.neural-paralysis
b.visceral-enlarged spleen, liver and gonads
c.ocular- pearly eye =lymphoblastoid infiltration of the iris
3.Meleagrid Hv-1: same disease but in turkeys
Term
Adenoviridae (diseases-dogs)
Definition
1.CAV-1:infectious canine hepatitis
2.CAV-2:infectious canine laryngotracheitis "kennel cough"
* CAV-2 is milder than CAV-1.
Term
Adenoviridae (diseases-Avian)
Definition
1.EDS'76: Egg Drop Syndrome - thin and soft shelled eggs
2.Inclusion Body Hepatitis virus (IBH)-massive hepatitis with concurrant immunsuppression
3.Turkey Haemorrhagic Enteritis virus (HEV)
4. Pheasant marble spleen disease virus- sudden death with pulmonary edema and necrotic foci in the spleen
Term
Parvoviridae (diseases-Cats)
Definition
Feline panleucopenia virus(FPLV) (feline infectious enteritis):
-3 major clinical symptoms:
1.panleucopenia/enertitis
2.sudden death
3.cerebellar hypoplasia
Term
Parvoviridae (diseases-dogs)
Definition
1. CPV-1:canine minute virus is avirulent
2. CPV-2,CPV-2a and CPV-2b: canine parvovirus is very virulent and similar to FPLV.
Pathogenesis: similar to cats but has 3 major clinical signs:
1.panleucopenia/enteritis
2.generalized neonatal disease
3.myocarditis
Term
Parvoviridae (diseases-pig)
Definition
porcine parvovirus produces no overt signs but is a major cause of reproductive loss.
spectrum of symptoms: "SMEDI"
1.stillbirths
2.mummification
3.embryonic death
4.infertility
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