Shared Flashcard Set

Details

Vasodilators
Vasodilator drugs
11
Pharmacology
Graduate
10/25/2013

Additional Pharmacology Flashcards

 


 

Cards

Term

1) What is EDFR?

2) half life of Nitric Oxide?

3) Effects on CV?

4) Effects on Heme?

5) Effects on CNS with what receptor?

6) Effects on Immune?

Definition

1)        Endothelial-derived relaxing factor plays a strong role in local mediation…. EDRF is nitric oxide (NO)

2) 5 seconds

3) VASODILATION

4)Inhibits platelet aggregation and adhesion

5) neurotransmitter with NMDA receptor to modulate pain, anesthetic effects, memory….

6) macrophages stimulate NO production

 

 

Term
4 factorsthat increase nitric oxide synthesis
Definition

S.H.A.B.S.

 

Shear,

histamine,

acetylcholine,

bradykinin,

serotonin

Term

What is eNOS?

the process mechanism of eNOS?

Definition
Endothelial nitric oxide synthase catelyzes from L-Arginine
Term
1st mechanism of how NO causes vasodilation
Definition

 

Guanylyl cyclase catalyzes the conversion of GTP to cGMP

 

cGMP activates Myosin light chain phosophatase

 

the MLC is dephosphorylated, preventing the actin-myosin cross bridge complex from forming

 

 

Term
2nd mechanism on how NO causes vasodilation
Definition

o   NO can directly stimulate potassium channels on the VSM cell

§  Once open, potassium efflux occurs and the cell hyperpolarizes, preventing the activation of the voltage gated Ca++ channels >>> relaxation

Term

What is Endothelin?

Where is it derived?

How does it affect NO

Definition

1) extremely potent endogenous vasoconstrictor

2) It is derived in the endothelium

3) antagonistic against NO

4) It binds to endothelin receptor

Term
What two disease process will you use Nipride for?
Definition

1) CHF

2) Rapid increase and precise blood pressure

Term
What in the blood determines breakdown of NO?
Definition

methemoglobin

anemic patient will have a low methemoglobin

Term

Nipride amount in bag (what kind of solution)?

Bolus dose:

Infusion dose?

Max infusion dose and amount time it can be ran?

onset:

duration:

Definition

amount 50mg/250ml of d5w

bolus: 0.5-1mcg/kg (50-100 mcg)

infusion: 0.3 mcg/kg/min w/max of 10mcg/kg/min

DO NOT RUN MAX LONGER THAN 10 MINUTES

1-2 minutes

2minutes

Term

CYANIDE METABOLISM

Cyanide is converted (in the liver) to ________ …this process requires a sulfur donor

Definition

1) thiocyanate

2)  thiosulfate

Term

Thiocyanate diffuses into where?

Half life of ______

excreted by ______

Definition
Supporting users have an ad free experience!