1) What is EDFR?

2) half life of Nitric Oxide?

3) Effects on CV?

4) Effects on Heme?

5) Effects on CNS with what receptor?

6) Effects on Immune?

1)        Endothelial-derived relaxing factor plays a strong role in local mediation…. EDRF is nitric oxide (NO)

2) 5 seconds

3) VASODILATION

4)Inhibits platelet aggregation and adhesion

5) neurotransmitter with NMDA receptor to modulate pain, anesthetic effects, memory….

6) macrophages stimulate NO production

S.H.A.B.S.

Shear,

histamine,

acetylcholine,

bradykinin,

serotonin

What is eNOS?

the process mechanism of eNOS?

Guanylyl cyclase catalyzes the conversion of GTP to cGMP

cGMP activates Myosin light chain phosophatase

the MLC is dephosphorylated, preventing the actin-myosin cross bridge complex from forming

o   NO can directly stimulate potassium channels on the VSM cell

§  Once open, potassium efflux occurs and the cell hyperpolarizes, preventing the activation of the voltage gated Ca⁺⁺ channels >>> relaxation

What is Endothelin?

Where is it derived?

How does it affect NO

1) extremely potent endogenous vasoconstrictor

2) It is derived in the endothelium

3) antagonistic against NO

4) It binds to endothelin receptor

1) CHF

2) Rapid increase and precise blood pressure

methemoglobin

anemic patient will have a low methemoglobin

_{Nipride amount in bag (what kind of solution)?}

_{Bolus dose:}

_{Infusion dose?}

_{Max infusion dose and amount time it can be ran?}

_onset:

_duration:

amount 50mg/250ml of d5w

bolus: 0.5-1mcg/kg (50-100 mcg)

infusion: 0.3 mcg/kg/min w/max of 10mcg/kg/min

DO NOT RUN MAX LONGER THAN 10 MINUTES

1-2 minutes

2minutes

CYANIDE METABOLISM

Cyanide is converted (in the liver) to ________ …this process requires a sulfur donor

1) thiocyanate

2)  thiosulfate

Thiocyanate diffuses into where?

Half life of ______

excreted by ______