Term
| Sickle Cell AA Substitution? |
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Definition
| Valine replaces Glutamic Acid at position 6 in the Beta Chain |
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Term
|
Definition
HbA: Majority
HbA1c: Useful for diabetes monitoring
HbA2: Normal but low amounts
HbF: Fetal |
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Term
| In a hemoglobin subunit, either O2 or H2O are sandwhiched between what? |
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Definition
The Heme (iron) and the distal His-64.
His-93 is on the other side |
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Term
| Collagen Structure Formula: |
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Definition
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Term
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Definition
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Term
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Definition
| substrate conc. at half of Vmax |
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Term
|
Definition
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Term
| Lineweaver Burke X-intercept = |
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Definition
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|
Term
| LineweaverBurke Y-intercept = |
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Definition
|
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Term
|
Definition
| L THOIL (Lyases, Transferases, Hydrolases, Oxidoreductases, Isomerases, Ligases) |
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Term
| Serine Protease Catalytic Triad: |
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Definition
Ser-His-Asp
Serine, Histidine, Aspartic Acid |
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Term
| NonCompetitive Inhibition: |
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Definition
Binds to [E] and [ES]
Vmax decreases. Km unchanged.
LWB Plot: Only Y-int Changes |
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Term
|
Definition
Binds [ES].
Vmax decreased. Km decreased.
LWB Plot: Changes Parallel |
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Term
|
Definition
Binds [E].
Vmax unchanged. Km increased.
LWB Plot: Only X-int Changes |
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Term
|
Definition
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Term
|
Definition
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Term
| Which is stronger: FAD or NAD? |
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Definition
| FAD, often used to oxidize C-C bonds. Found in enzyme active sites usually. |
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Term
| De novo synthesis occurs in the: |
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Definition
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|
Term
| Salvage synthesis occurs in the: |
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Definition
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Term
|
Definition
| Phosphate Ribose PyroPhosphate |
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Term
| Committed step in Purine synth: |
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Definition
| Glutamine:PRPP Amidotransferase |
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Term
|
Definition
| 1. Increased PRPP 2.Partial loss of HGPRT activity 3.Loss of Feedback Inhibition |
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Term
|
Definition
| Deficiency of HGPRT, causes high amounts of PRPP and purine synthesis (lots of Uric Acid) |
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Term
|
Definition
| Major Salvage pathway enzyme. |
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Term
| Pyramidine Synthesis Committed Step: |
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Definition
| Asparatate Transcarbomylase "ATCase" |
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Term
| Pyramidine Synth. Regulators: |
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Definition
1) CTP regulates CPSII (the first enzyme), and itself.
2) GTP stimulates CTPS to make more CTP |
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Term
|
Definition
| Structural Analog of hypoxanthine. Suicide inhibitor of xanthine oxidase. |
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Term
| Drugs to stop Thymine Synth: |
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Definition
| 5-fluoroUracil and Methotrexate inhibit THF regeneration. |
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Term
| SCIDS (Adenosine Deamininase Deficiency) |
|
Definition
| causes dATP buildup. dATP is master negative regulator of dNTP synthesis. So with SCIDS very few dNTP's are synthesized. |
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Term
|
Definition
Repaired by Base Excision Repair.
Depurination= loss of G
Deamination= C changed to U. Or 5Methyl-C changed to T <---Very mutagenic. |
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Term
|
Definition
"Hereditary Non-Polyposis Colon Cancer"
heterozygote for mutation in mismatch repair genes. |
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Term
| Replication errors are fixed by: |
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Definition
| Proofreading or mismatch repair |
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Term
| Endogenous DNA errors are fixed by: |
|
Definition
| Base Excision Repair System |
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Term
| Exogenous DNA Damage (bulky lesions are fixed by: |
|
Definition
| Nucleotide Excision Repair |
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|
Term
| Breaks in DNA are fixed by: |
|
Definition
| Recombination Repair using RecA |
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Term
|
Definition
| skin problems caused by defective telomerase enzyme |
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Term
|
Definition
| defects in Nucleotide Excision Repair |
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Term
|
Definition
| facilitates Homologous Recombination and heteroduplex formation |
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Term
|
Definition
Anaerobic: Lactate
Aerobic: Acetyl CoA
or just used as Alanine |
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Term
|
Definition
| 2 pyruvate. 2 ATP. 2 NADH. (niacin deficiency inhibits it then) |
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Term
|
Definition
| Carbamoyl Phosphate and Aspartic Acid |
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Term
|
Definition
| Aspartic Acid, Glycine, Glutamine and CO2 |
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Term
|
Definition
| U1, U2, U4, U5, U6, and 7 other proteins |
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Term
|
Definition
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Term
|
Definition
Hydroxyprolines do Hydrogen bonding w/in.
Lysines do covalent bonding between. |
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Term
|
Definition
Hydrogen + vanDerWaals w/in.
Disulfide bonds between filaments. |
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Term
|
Definition
| Can't synthesize Pyramidines. Treat w/something near end product. |
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Term
|
Definition
| Dissociation Constant for Inhibitor from the Enzyme |
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