Term
| Alpha 1 (G-protein class and fuctions) |
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Definition
| Sympathetic; Gq; Increase VSMC tone, increase GI/GU sphincter tone, dilate pupils |
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Term
| Alpha 2 (G-protein class and fuctions) |
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Definition
| Sympathetic; Gi; Negative feedback by sympathetics, decrease Insulin |
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Term
| Beta 1 (G-protein class and fuctions) |
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Definition
| Sympathetic; Gs; Increase HR/contractility, Increase lipolysis, Increase Renin |
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Term
| Beta 2 (G-protein class and fuctions) |
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Definition
| Sympathetic; Gs; Increase HR/contractility, Increase lipolysis, Increase Insulin; Decrease VSMC/BSMC tone; Decrease Uterine tone |
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Term
| M1 (G-protein class and fuctions) |
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Definition
| Parasympathetic; Gq; CNS/Enteric NS |
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Term
| M2 (G-protein class and fuctions) |
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Definition
| Parasympathetic; Gi; Decrease HR, decrease contractility of atria |
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Term
| M3 (G-protein class and fuctions) |
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Definition
| Parasympathetic; Gq; Increase exocrine gladular secreation, Increase pupil size, Acomodation, Increase GI motility, Increase blader tone, Decrease VSMC tone |
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Term
| D1 (G-protein class and fuctions) |
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Definition
| Dopamine; Gs; Decrease Renal VSMC tone |
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Term
| D2 (G-protein class and fuctions) |
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Definition
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Term
| H1 (G-protein class and fuctions) |
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Definition
| Histamine; Gq; Puritis, pain, Increase Nasal/bronchial secreations, increase BSMC tone |
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Term
| H2 (G-protein class and fuctions) |
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Definition
| Histamine; Gs; Increase Gastric acid secretion |
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Term
| V1 (G-protein class and fuctions) |
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Definition
| Vasopresin; Gq; Increase VSMC tone |
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|
Term
| V2 (G-protein class and fuctions) |
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Definition
| Vasopresin; Gs; Increase aquaporins in collecting tubules |
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Term
|
Definition
| Activating Phospholipase C which converts Lipids to PIP2 to IP3/DAG. IP3 increase intracellular Ca levels, DAG activates Protein Kinase C |
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Term
|
Definition
| Activating Adenylyl Cyclase which converts ATP to cAMC. Increased cAMP Levels activate Protein kinase A |
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Term
|
Definition
| Inactivates Adenylyl Cyclase, reduces cAMP levels, therefore reduces Protein Kinase A levels |
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Term
|
Definition
| Prevents Choline uptake, reduces ACh levels |
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Term
|
Definition
| Prevents ACh loading in vesicles, reduces ACh levels |
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Term
|
Definition
| Prevents ACh loaded vesicles from fusing with plasma membrane, reduces ACh levels in synaptic cleft |
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Term
|
Definition
| Prevents Tyrosine conversion to DOPA (reduces DOPA/Dopanine/NE/Epi levels) |
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Term
|
Definition
| Prevents NE loading into vesicles |
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Term
|
Definition
| Prevents NE loaded vesicles from fusing with plasma membranes |
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Term
|
Definition
| Stimulates NE relsease, prevents NE uptake |
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Term
|
Definition
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|
Term
|
Definition
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Term
|
Definition
| Cholenergic direct agonist,activates bowel/bladder smooth muscles |
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Term
|
Definition
| ACh direct agonist; release of intraocular pressure |
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Term
|
Definition
| Pile on the sweat/ears/saliva |
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Term
|
Definition
| Used in Methacholine test for asthma. Sensitivity to small doses is positive. |
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Term
|
Definition
| AChE inhibitor; Myasthenia gravis, post OP neuromuscular block reversal; NO CNS |
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Term
|
Definition
| AChE inhibitor; Myasthenia gravis, NO CNS |
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Term
|
Definition
| AChE inhibitor; Diagnosis of Myasthenia gravis, very short acting |
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Term
|
Definition
| AChE inhibitor; Glaucoma and atropine OD. Crosses CNS |
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Term
|
Definition
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|
Term
| AChE inhibitor toxicity (Symptoms and Antedote)? |
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Definition
| DUMBBELSS = Diarrhea, Urination, Miosis, Bronchospasm, Bradychardia, Excitation of muscles, Lacrimation, Sweating, Salivations. Antidote - Atropine |
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Term
|
Definition
| Muscurinic Antagonist; Increase Pupil diameter, cycloplegia, decrease nasal/bronchial secretions, decrease GU/GI motility. Blocks effects of AChE inhibitors. OD: Increase Temp, rapid pulse, dry mouth, dry flushed skin, constipation. |
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Term
|
Definition
| Increase pupil size, cycloplegia |
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Term
|
Definition
| Muscarinic Antagonist; Used in Parkinsons, PARK my BENZ |
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Term
|
Definition
| Muscarinic Antagonist; Used in motion sickness. |
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Term
|
Definition
| Muscarinic Antagonist; I PRAY I can breath, Asthma, COPD |
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Term
|
Definition
| Muscarinic Antagonist; Reduced urinary urgency |
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Term
|
Definition
| Muscarinic Antagonist; used for peptic ulcers. |
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Term
|
Definition
| all Alpha 1/2 and beta 1/2 |
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Term
|
Definition
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|
Term
| Isoproterenol selectivity? |
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Definition
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|
Term
|
Definition
|
|
Term
|
Definition
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|
Term
| Phenylnephrine (selectivity) |
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Definition
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|
Term
|
Definition
| MAST: Metaproterenol, Albuterol, Salmeterol, Terbutaline, Ritodrine |
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Term
| Clonidine/Alpla-methyldopa selectivity? |
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Definition
| Central A2 agonists, decrease central adrenergic outflow |
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Term
| Non selective Alpha blockers |
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Definition
Phenoxybenzamine (irreversible - used prior to pheochromocytoma surgery to negate effect of spilled chatecholamines)
Phentolamine (reversible) |
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Term
|
Definition
| Prozosin, terazosin, doxazosin |
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Term
|
Definition
| Mitazapine - for depression, sedation |
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Term
|
Definition
| Propranolol, timolol, nadolol, pindolol, labitalol |
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Term
|
Definition
| A BEAM of B1 blockers: Acebutalol, Betaxolol, Esmolol, Atenolol, Metoprolol |
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