Term
| What is the equation for Volume of Distribution? |
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Definition
| VD = (amt of drug given IV)/ [drug]plasma |
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Term
| What is the equation for clearance? |
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Definition
| Cl = (0.7 X VD)/ half-life |
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Term
| What is the equation for loading dose? |
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Definition
| LD = (steady state conc) x VD |
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Term
| What is the equation for maintenance dose? |
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Definition
| MD = (steady state conc) x CL |
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Term
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Definition
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Term
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Definition
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Term
| Drug class? Echothiophate |
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Definition
| Anti-cholinesterase (Indirect cholinergic) |
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
| Cholinesterase regenerator |
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Term
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Definition
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Term
| Drug class? "--trop--" (ipratropium, tropicamide, benztropine, aTROPine) |
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Definition
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Term
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Definition
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Term
|
Definition
| Anticholinesterase (Indirect cholinergic) |
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Term
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Definition
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Term
| What is the MOA of botulinum toxin? |
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Definition
| Inhibits the PRESYNAPTIC release of Ach (causes FLACCID paralysis) |
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Term
| What is the MOA of cocaine, TCA's, and amphetamines? |
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Definition
| Blocks reuptake of NE into the presynaptic cleft |
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Term
| What is the MOA of Guanethidine? |
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Definition
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Term
| What anticholinesterase is used for post-operative ileus? |
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Definition
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Term
| Which receptors stimulate G(q)? |
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Definition
| H1 A1 V1 M1 M3 (HAVe 1 M&M) |
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Term
| Which receptors stimulate G(i)? |
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Definition
|
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Term
| What enzyme does G(q) activate? |
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Definition
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Term
| Drug class? Hexamethonium |
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Definition
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Term
| How does Hexamethonium affect heart rate? |
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Definition
| Prevents vagal reflax responses to changes in blood pressure (ie. prevents reflex bradycardia caused by NE) |
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Term
| Stimulated Receptors? Clonidine |
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Definition
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Term
| Stimulated Receptors? Dopamine |
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Definition
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Term
| Stimulated Receptors? Phenylephrine |
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Definition
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Term
| Stimulated Receptors? Albuterol |
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Definition
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Term
| Stimulated Receptors? Norepinephrine |
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Definition
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Term
| Stimulated Receptors? Isoproterenol |
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Definition
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Term
| Stimulated Receptors? Epinephrine |
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Definition
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Term
| Stimulated Receptors? Dobutamine |
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Definition
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Term
| Stimulated Receptors? Terbutaline |
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Definition
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Term
| What is the most common first line agent for pts in cardiogenic shock? |
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Definition
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Term
| Which drug is given subQ for asthma? |
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Definition
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Term
| What drug is indicated in shock that MAINTAINS RENAL BLOOD FLOW? |
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Definition
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Term
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Definition
| Phenothiazine (neuroleptic, anti-emetic) |
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
| Drug class? "--triptyline" |
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Definition
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Term
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Definition
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Term
|
Definition
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Term
|
Definition
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Term
| Drug class? "--curium/curonium" |
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Definition
| NON-DEPOLARIZING neuromuscular blocker |
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Term
| Drug class? "--glitazone" |
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Definition
| Diabetes drug (increases tissue sensitivity) |
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Term
|
Definition
| dihydroperidine Ca channel blocker |
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Term
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Definition
| HMGCoA reductase inhibitor |
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Term
| What is the only DEPOLARIZING neuromuscular blocking drug? |
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Definition
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Term
| What are the 5 classes of drugs used to treat glaucoma? |
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Definition
| 1. B-blockers 2. alpha agonists 3. diuretics (acetazolamide, mannitol-acute) 4. prostaglandins 5. cholinergics |
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Term
| In what population must B-blockers be administered with extra caution? |
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Definition
| Diabetics because it can mask the symptoms of hypoglycemia |
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Term
| What 3 drugs are composed of antibodies against TNF? |
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Definition
1. Etanercept
2. Infliximab
3. Adalimumab |
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Term
| What screening test should be performed before placing a patient on Infliximab? |
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Definition
| PPD test because infliximab can reactivate latent TB |
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Term
| What causes "Gray Baby" syndrome? What causes "Gray Man" syndrome? |
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Definition
Gray Baby-- Chloramphenicol
Gray Man-- Amiodarone (photosensitivity) |
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Term
| What are 7 drugs that should be avoided in people with sulfa allergies? |
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Definition
| Thiazide diuretics, loop diuretics (furosemide), Bactrim, Sulfasalazine, sulfonureas, sumatriptan |
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Term
| What 2 alpha-adrenergic antagonists are used in the treatment of pheochromocytoma? |
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Definition
| phenoxybenzamine and phentolamine |
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Term
| What is the DOC for anaphylactic shock? |
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Definition
|
|
Term
| What is the DOC for cardiogenic shock? |
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Definition
|
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Term
| What is the DOC for septic shock? |
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Definition
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Term
| What types of adrenergic receptors are found on the beta cells of the pancreas? What effects do these have? |
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Definition
alpha-2: inhibit insulin
beta: increases insulin |
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Term
| What type of adrenergic receptors are found on the alpha cells of the pancreas? |
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Definition
| alpha-2 to increase glucagon |
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Term
| What 5 drugs (pneumonic?) are known for causing drug-induced Lupus? |
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Definition
| "SHIPP" Sulfonamides, Hydralazine, INH, Pracainamide, Phenytoin |
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Term
| What are the 4 R's of Rifampin? |
|
Definition
1. RNA polymerase inhibitor
2. Revs up P450
3. Red/orange body fluids
4. Rapid resistance (if used alone) |
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Term
| What is the pneumonic for INDUCING cytochrome P450? What does it stand for? |
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Definition
| "BCG PQRS" ...Barbituates, Carbamazepine, Griseofulvin, Phenytoin, Quinidine, Rifampin, St. John's Wort |
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Term
| What is the pneumonic for INHIBITING cytochrome P450? What does it stand for? |
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Definition
| "PICK EGS"...Protease inhibitors, INH, Cimetidine, Ketoconazole, Erithromycin, Grapefruit juice, Sulfonamides |
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Term
| What drug would you use for prophylaxis for someone w/ exposure to meningococcal or H.flu type B meningitis? |
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Definition
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Term
| What's the antidote/treatment for toxicity? Acetominophen |
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Definition
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Term
| What's the antidote/treatment for toxicity? Salicylates |
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Definition
| NaHCO3 (alkalizing urine), dialysis |
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Term
| What's the antidote/treatment for toxicity? Amphetamines |
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Definition
|
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Term
| What's the antidote/treatment for toxicity? Anticholinesterases/organophosphates (2) |
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Definition
|
|
Term
| What's the antidote/treatment for toxicity? Antimuscarinic/anticholinergic agents |
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Definition
| Physostigmine salicylate ("phyxes atropine overdose") |
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Term
| What's the antidote/treatment for toxicity? Beta-blockers (3) |
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Definition
|
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Term
| What's the antidote/treatment for toxicity? verapamil (3) |
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Definition
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Term
| What's the antidote/treatment for toxicity? Digitalis (if there is tachycardia) |
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Definition
| normalize K+, LIDOCAINE, anti-dig fab, Mg2+ |
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Term
| What's the antidote/treatment for toxicity? Digitalis (if there is bradycardia) |
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Definition
| normalize K+, ATROPINE, anti-dig fab, Mg2+ |
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Term
| What's the antidote/treatment for toxicity? Iron (transfusions, hemochromatosis) |
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Definition
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Term
| What's the antidote/treatment for toxicity? Lead (4) |
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Definition
| EDTA, dimercaprol, succimer (kids), penicillamine |
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Term
| What's the antidote/treatment for toxicity? Mercury, arsenic, gold |
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Definition
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Term
| What's the antidote/treatment for toxicity? copper, arsenic, gold |
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Definition
|
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Term
| What's the antidote/treatment for toxicity? cyanide (nitroprusside) |
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Definition
| nitrite, hydroxycobalamin, THIOSULFATE |
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Term
| What's the antidote/treatment for toxicity? Methemoglobin |
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Definition
| Methylene Blue, Vitamin C |
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Term
| What's the antidote/treatment for toxicity? Carbon monoxide |
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Definition
|
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Term
| What's the antidote/treatment for toxicity? Methanol, ethanol glycol (antifreeze) |
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Definition
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|
Term
| What's the antidote/treatment for toxicity? opioids |
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Definition
|
|
Term
| What's the antidote/treatment for toxicity? benzodiazepines |
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Definition
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Term
| What's the antidote/treatment for toxicity? TCA's |
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Definition
| NaHCO3 (serum alkalinization) |
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Term
| What's the antidote/treatment for toxicity? Heparin |
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Definition
|
|
Term
| What's the antidote/treatment for toxicity? Warfarin |
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Definition
|
|
Term
| What's the antidote/treatment for toxicity? tPA, streptokinase |
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Definition
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Term
| What's the antidote/treatment for toxicity? theophylline |
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Definition
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Term
| What is ethambutol used for and why is it avoided in children? |
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Definition
| It is part of the treatment regimen for TB (RIPE), it's toxicity causes red-green color blindness |
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Term
| First line treatment for psychosis? |
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Definition
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Term
| What reactions are catalyzed by cytochrome P450? (3) |
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Definition
| Reduction, oxidation, hydrolysis |
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Term
| Side effect of which drug(s)? gingival hyperplasia |
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Definition
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Term
| Side effect of which drug(s)? gout (2) |
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Definition
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Term
| Side effect of which drug(s)? osteoporosis (2) |
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Definition
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Term
| Side effect of which drug(s)? Photosensitivity |
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Definition
"SAT for a photo"
Sulfonamides, Amiodarone, Tetracyclines |
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Term
| Side effect of which drug(s)? tendon rupture/cartilage damage |
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Definition
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Term
| Side effect of which drug(s)? Fanconi's syndrome |
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Definition
| expired tetracyclines, heavy metals |
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Term
| Side effect of which drug(s)? interstitial nephritis (3) |
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Definition
| methicillin, NSAIDs, furosemide |
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Term
| Side effect of which drug(s)? hemorrhagic cystitis |
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Definition
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Term
| Side effect of which drug(s)? dizziness, nausea, headache, vision changes, tinnitus |
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Definition
| Quinine, quinidine (cinchonism) |
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Term
| Side effect of which drug(s)? nephrogenic diabetes insipidus (2) |
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Definition
| lithium and demeclocycline |
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Term
| Side effect of which drug(s)? seizures (3) |
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Definition
| buproprion, INH, imipenem/cilastin |
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Term
| Side effect of which drug(s)? tardive dyskinesia |
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Definition
| high potency neuroleptics |
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Term
| Side effect of which drug(s)? nephro and neurotoxicity |
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Definition
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Term
| What drug(s) has the potential side effect? atropine-like side effects (4) |
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Definition
| TCA's, low potency antipsychotics, diphenhydramine, premethazine |
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Term
| What drug(s) has the potential side effect? coronary vasospasm (3) |
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Definition
| cocaine, sumatriptan, ergotamines |
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Term
| What drug(s) has the potential side effect? cutaneous flushing (4--VANC) |
|
Definition
Vancomycin
Adenosine
Niacin
Ca2+ channel blockers |
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|
Term
| What drug(s) has the potential side effect? Dilated cardiomyopathy (2) |
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Definition
|
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Term
| What drug(s) has the potential side effect? torsades de pointes |
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Definition
| Anything that prolongs the QT interval(Crazy huge mosquitos with arrhythmias and AIDS)...Haloperidol, macrolides, chloroquine, 1A and III antiarrhythmics, protease inhibitors) |
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Term
| What drug(s) has the potential side effect? agranulocytosis |
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Definition
| 3C's, hyperthyroid, leprosy...Clozapine, Carbamazapine, Colchicine, MMU, PTU, dapsone |
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Term
| What drug(s) has the potential side effect? direct Coomb's positive hemolytic anemia (1) |
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Definition
|
|
Term
| What drug(s) has the potential side effect? Hemolysis in G6PD pts |
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Definition
| "PAIN IS Definitely Not Fun"...Primaquine, Aspirin (high dose), Isoniazid, Nitrofurantoin, Ibuprofen, Sulfonamides, Dapsone, Naptholene, Fava beans |
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Term
| What drug(s) has the potential side effect? Megaloblastic anemia (3) |
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Definition
| PMS! Phenytoin, Methotrexate, Sulfa drugs |
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Term
| What drug(s) has the potential side effect? Thrombocytopenia (2) |
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Definition
|
|
Term
| What drug(s) has the potential side effect? pulmonary fibrosis (3) |
|
Definition
| BAB...Bleomycin, amiodarone, busulfan |
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Term
| What drug(s) has the potential side effect? Acute cholestatic hepatitis |
|
Definition
| Macrolides (erythromycin estolate) |
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Term
| What drug(s) has the potential side effect? focal to massive hepatic necrosis (4) |
|
Definition
| "HAVA" valproic acid, halothane, acetominophen, amanita phylloides |
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Term
| What drug(s) has the potential side effect? Hepatitis |
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Definition
|
|
Term
| What drug(s) has the potential side effect? tertiary adrenocortical insufficiency |
|
Definition
| glucocorticoid withdrawal (HPA suppression) |
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Term
| What drug(s) has the potential side effect? gynecomastia |
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Definition
| "Some Drugs Create Awesome Knockers"...Spironolactone, Digitalis, Cimetidine, Alcohol (chronic), Ketoconazole |
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Term
| What drug(s) has the potential side effect? hot flashes (2) |
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Definition
|
|
Term
| What drug(s) has the potential side effect? hypOthyroidism |
|
Definition
| "LA" Lithium and Amiodarone |
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|
Term
| What do you give for a bradycardic digitalis overdose? |
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Definition
|
|
Term
| What do you give for a tachycardic digitalis overdose? |
|
Definition
| lidocaine and anti-dig fragments |
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|
Term
| An AA male that goes to Africa develops anemia after taking prophylactic medicine for primary dz prevention, what enzyme is he deficient in? |
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Definition
|
|
Term
| A patient presents with tinnitis, dizziness, headache, and GI distress, what drug is causing these symptoms? |
|
Definition
| Cinchonism (Quinidine, Quinine, Aspirin toxicity) |
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Term
| What drugs are used to treat Parkinson's dz? |
|
Definition
| "BALSA"...Bromocriptine, Amantadine, Levodopa (w/carbidopa), Selegiline (and COMTi's), Anti-cholinergics (benztropine) |
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|
Term
| Which drugs cause gynecomastia? |
|
Definition
| "Some Drugs Cause Awesome Knockers"... Spironolactone, Digitalis, Cimetidine, Alcohol (chronic), Ketoconazole |
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|
Term
| What 3 drugs cause photosensitivity? |
|
Definition
| "i SAT for a PHOTO"...Sulfas, Amiodarone, Tetracyclines |
|
|
Term
| What enzyme of the arachidonic pathway do glucocorticoids inhibit? |
|
Definition
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