Term
| CD Marker? Expressed only by helper T cells |
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Definition
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Term
| CD Marker? Expressed by cytotoxic T cells and suppressor T cells |
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Definition
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Term
| CD Marker? Found on all T cells except NK cells |
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Definition
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Term
| CD Marker? Used to identify B cells |
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Definition
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Term
| CD Marker? Found on all NK cells and binds to the constant region of IgG |
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Definition
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Term
| CD Marker? Inhibits complement C9 binding (protects against complement-mediated damage |
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Definition
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Term
| CD Marker? Endotoxin receptor found on macrophages |
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Definition
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Term
| What cytokine(s)? promotes B cell growth and differentiation |
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Definition
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Term
| What cytokine(s)? Produced by Th-1 cells |
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Definition
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Term
| What cytokine(s)? Produced by Th-2 cells |
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Definition
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Term
| What cytokine(s)? Involved in growth and activation of eosinophils |
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Definition
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Term
| What cytokine(s)? Secreted by helper T cells and ACTIVATES MACROPHAGES |
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Definition
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Term
| What cytokine(s)? Inhibits macrophage activation |
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Definition
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Term
| What cytokine(s)? Pyogens secreted by monocytes and macrophages |
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Definition
| IL-1, IL-6, TNF-alpha (acute phase cytokines) |
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Term
| What cytokine(s)? Inhibits the production of Th-1 cells |
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Definition
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Term
| What cytokine(s)? Inhibits the production of Th-2 cells |
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Definition
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Term
| What cytokine(s)? Mediates inflammation |
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Definition
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Term
| What cytokine(s)? Enhances synthesis of IgE and IgG |
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Definition
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Term
| What cytokine(s)? Enhances synthesis of IgA |
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Definition
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Term
| What cytokine(s)? Released by virally infected cells |
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Definition
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Term
| What cytokine(s)? Supports growth and differentiation of bone marrow stem cells |
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Definition
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Term
| What cytokine(s)? Supports T cell proliferation, differentiation, and activation |
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Definition
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Term
| Immunoglobulin isotype? comprises 70-75% of total immunoglobulin pool |
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Definition
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Term
| Immunoglobulin isotype? Present in large quantities on the membrane of many B cells |
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Definition
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Term
| Immunoglobulin isotype? Can occur as a dimer |
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Definition
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Term
| Immunoglobulin isotype? Largely confined to intravascular pool and is the predominant early ab seen in response to infectious organisms w/ complex antigens |
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Definition
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Term
| Immunoglobulin isotype? Distributed evenly b/w intravascular and extravascular pools |
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Definition
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Term
| Hypersensitivity Rxn? Post-streptococcal glomerulonephritis |
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Definition
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Term
| Hypersensitivity Rxn? asthma |
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Definition
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Term
| Hypersensitivity Rxn? Rheumatic fever |
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Definition
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Term
| Hypersensitivity Rxn? SLE |
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Definition
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Term
| Hypersensitivity Rxn? Tuberculous skin test (PPD) |
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Definition
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Term
| Hypersensitivity Rxn? allergies, anaphylaxis, and hay fever |
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Definition
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Term
| Hypersensitivity Rxn? Polyarteritis nodosa |
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Definition
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Term
| Hypersensitivity Rxn? serum sickness |
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Definition
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Term
| Hypersensitivity Rxn? ABO blood type incompatibility |
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Definition
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Term
| Hypersensitivity Rxn? Poison Ivy |
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Definition
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Term
| Hypersensitivity Rxn? Eczema |
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Definition
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Term
| Hypersensitivity Rxn? Contact dematitis |
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Definition
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Term
| Hypersensitivity Rxn? Goodpasture's Syndrome |
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Definition
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Term
| Which complement is responsible for neutrophil chemotaxis? |
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Definition
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Term
| Child presents w/ tetany f/ hypOcalcemia and candidiasis. Dx? |
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Definition
| T Cell deficiency (DiGeorge) |
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Term
| What is the deficient enzyme in Chronic Granulomatous Dz? |
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Definition
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Term
| Immunodeficiency Dz? X-linked B cell deficiency, low Ig's, recurrent bacterial infxns |
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Definition
| Bruton's Agammaglobulinemia |
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Term
| What gene is defective in Bruton's Agammaglobulinemia? |
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Definition
| Defective Tyrosine Kinase gene |
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Term
| Immunodeficiency Dz? No T cells, hypOcalcemia/tetany, congenital heart/great vessel defects, recurrent fungal/viral/protozoal infxns |
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Definition
| Thymic aplasia (DiGeorge) |
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Term
| What embryonic pouches fail to develop in DiGeorge Syndrome? |
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Definition
| 3rd and 4th pouches....no thymus, no T cells |
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Term
| What chromosomal deletion is present in 90% of DiGeorge pts? |
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Definition
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Term
| Immunodeficiency Dz? What is the presentation triad of SCID? |
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Definition
1. Severe recurrent infxns (B and T cell deficiency)
2. Chronic diarrhea
3. Failure to thrive |
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Term
| What 2 immunodeficiency dzs have no thymic shadow on CXR? |
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Definition
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Term
| Immunodeficiency Dz? What is the deficient cell type in Chronic Mucocutaneous Candidiasis? What is the Tx? |
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Definition
| T cell dysfxn, Treat w/ ketoconazole |
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Term
| What are the 3 always X-linked immunodeficiencies? ("WBC") |
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Definition
W- Wiskott-Aldrich
B- Bruton's Agammaglobulinemia
C- Chronic Granulomatous Dz |
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Term
| What are the "WAITER" components of Wiskott-Aldrich Syndrome? |
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Definition
W-A-I- Wiskott-Aldrich Immunodeficiency
T- Thrombocytopenia and Purpura
E- Eczema (central, not extensors)
R- Recurrent pyogenic infxns
.......low IgM, high IgA |
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Term
| What is the most common selective immunoglobulin deficiency and why is it important to diagnose? |
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Definition
| IgA deficiency is most common. Pts are susceptible to sinus and lung problems, but usu don't know they have the deficiency. Should be dx bc can have anaphylaxis to blood transfusions and blood products |
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Term
| What Ig is deficient in Ataxia-telangiectasia? What are pts at increased risk for? |
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Definition
| IgA deficiency, pts at increased risk for lymphoma and acute leukemias |
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Term
| Immunodeficiency Dz? Poor smooth pursuit of moving target w/eyes, radiation sensitivity (defective DNA repair), possibly increased alpha-fetoprotein |
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Definition
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Term
| What cytokine receptor is deficient in mycobacterial infxn susceptibility? |
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Definition
| IL-12 receptor deficiency |
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Term
| What are the 4 major phagocyte deficiencies? |
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Definition
1. Chronic Granulomatous Dz
2. Chediak-Higashi Dz
3. Job's Syndrome
4. Leukocyte Adhesion Deficiency |
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Term
| What types of bacteria are pts w/ CGD especially susceptible to? |
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Definition
| Catalase (+) bacteria (staph aureus, e.coli, klebsiella, aspergillus, candida) |
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Term
| What do you diagnose Chronic Granulomatous Dz with? |
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Definition
| Nitroblue Tetrazolium (NBT) dye...Does NOT change f/ yellow --> black like it should bc there is no oxidation |
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Term
| Immunodeficiency Dz? Defective LYST gene (Lysosomal Transport) |
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Definition
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Term
| What is the diagnostic cytology of Chediak Higashi Dz? |
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Definition
| Giant cytoplasmic granules in PMN's (defecttive phagocyte lysosome) |
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Term
| What is the presentation triad of Chediak-Higashi Dz? |
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Definition
1. Partial albinism
2. Recurrent respiratory tract and skin infxn
3. Neurologic d/o's |
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Term
| What is another name for Job's Syndrome? |
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Definition
| Hyperimmunoglobulin E syndrome |
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Term
| Immunodeficiency Dz? Deficient IFN-gamma, PMN's fail to respond to chemotactic stimuli (C5a, LTB4) |
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Definition
| Job's (hyper IgE) syndrome |
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Term
| What is the presentation triad of Job's Syndrome? |
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Definition
1. Eczema
2. staph aureus COLD abcesses
3. coarse facies (broad nose, "doughy" skin, prominant forehead, etc) |
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Term
| What is unusual about the mouths of people with Job's syndrome? |
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Definition
| They retain their primary teeth, so they may have 2 rows of teeth (it is a "JOB" to take all those teeth out!) |
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Term
| Immunodeficiency Dz? Retained umbilical stump |
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Definition
| Leukocyte Adhesion Deficiency |
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Term
| What protein is deficient in Leukocyte Adhesion Deficiency? |
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Definition
| Abnormal INTEGRINS...inability of phagocytes to exit circulation and enter interstitium |
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Term
| What 3 drugs are composed of antibodies against TNF? |
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Definition
1. Etanercept
2. Infliximab
3. Adalimunab |
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Term
| After bone marrow transplant, pt suffers f/ dermatitis, enteritis, and hepatitis...what dz process is occuring? |
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Definition
| Graft-versus-host dz (GVHD) |
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Term
| In what dz would you see anti-mitochondrial antibodies? |
|
Definition
| Primary biliary cirrhosis |
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Term
| Which CD's are deficient in Paroxysmal Nocturnal Hemoglobinuria? |
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Definition
| CD55, CD59 (complement mediated lysis of RBC's = PNH)...deficiency in DAF (Decay Accelerating Factor) |
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Term
| Deficiency of what complements lead to susceptibility to Neisseria infxns? |
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Definition
|
|
Term
| What activates the Classic Complement pathway? |
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Definition
| Antigen-antibody complexes |
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Term
| What activates the alternative pathway? |
|
Definition
| microbes/microbial surfaces |
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Term
| How does Ham's Test work and what is it used to diagnose? |
|
Definition
| RBC lysis at low PH. Used to dx Paroxysmal Nocturnal Hemoglobinuria |
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|
Term
| Name 4 phagocyte deficiencies |
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Definition
1. Leukocyte Adhesion Deficiency
2. Chediak Higashi
3. Chronic Granulomatous Dz
4. Job's Syndrome (HyperIgE) |
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|
Term
| Name 3 X-linked immunodeficiencies |
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Definition
| "WBC" Wiskott Aldrich, Bruton's Agammaglobulinemia, CGD |
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Term
| What immunodeficiency? neutrophils fail to respond to chemotactic stimuli |
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Definition
| LAD (Leukocyte Adhesion Deficiency) or Job's (HyperIgE) |
|
|
Term
| What immunodeficiency? Adenosine Deaminase Deficiency |
|
Definition
|
|
Term
| What immunodeficiency? Failure of endodermal development |
|
Definition
|
|
Term
| What immunodeficiency? Defective tyrosine kinase gene |
|
Definition
| Bruton's Agammaglobulinemia |
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