Term
| What growth factor is most important for fibrosis ? |
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Definition
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Term
| What growth factor is used to heal diabetic foot ulcers (Regranex drug) ? |
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Definition
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|
Term
| Regranex drug is what growth factor ? |
|
Definition
|
|
Term
| What cells are least affected by chemo and radiation ? |
|
Definition
| Permanent cells like neurons, cardiac cells, and skeletal muscle |
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|
Term
| Most common cause of delayed wound healing ? |
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Definition
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|
Term
| Keloid is what type of collagen ? |
|
Definition
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|
Term
| Hydroxylation of collagen is mediated by what ? |
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Definition
|
|
Term
| Cross-linking of collagen is performed by ? |
|
Definition
Lysyl oxidase
Copper is a required co-factor |
|
|
Term
| What causes the proteinuria in nephrotic syndrome ? |
|
Definition
| Loss of negative charge of renal glomerular basement membrane |
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|
Term
| What are some antibodies to Goodpasture Syndrome ? |
|
Definition
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|
Term
| What collagen is found in the epiphyseal growth plate ? |
|
Definition
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|
Term
| What is the first finding in kidney disease ? |
|
Definition
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|
Term
| Ostegenesis Imperfecta is a defect in what collagen ? |
|
Definition
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|
Term
| What causes edema in heart failure ? |
|
Definition
| Increased hydrostatic pressure |
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|
Term
| What causes edema in liver disease, nephrotic syndrome, and protein deficiency (kwashiorkor) ? |
|
Definition
| Hypoalbuminemia and decreased colloid osmotic pressure |
|
|
Term
| What causes tissue swelling in Graves disease ? |
|
Definition
| Increased extracellular glycosaminoglycans |
|
|
Term
| What causes tissue swelling in Graves disease ? |
|
Definition
| Increased extracellular glycosaminoglycans |
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Term
|
Definition
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|
Term
| What are the only two types of non-pitting edema ? |
|
Definition
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|
Term
| What drug overdose causes pulmonary edema ? |
|
Definition
|
|
Term
Nutmeg liver photo)
1. What caused this ? |
|
Definition
1. Right sided heart failure
2. Centrilobular zone (Zone 3) |
|
|
Term
| What is Bernard-Soulier Syndrome ? |
|
Definition
Deficiency of platelet GP1b
Defective platelet adhesion
Look in vignette for history of bleeding in a family |
|
|
Term
| What is Glanzmann Thrombasthemia ? |
|
Definition
Deficiency of GP2b/3a
Defective platelet aggregation |
|
|
Term
| What collagen is an anchoring filament and found in skin ? |
|
Definition
|
|
Term
|
Definition
Treat the underlying disorder, b/c
DIC is always secondary to another disorder |
|
|
Term
| Abnormal Ristocetin test can be found in ? |
|
Definition
Von Willebrand's disease mostly
but also Bernard Soulier's disease |
|
|
Term
| Desmopressin can be used to treat ? |
|
Definition
Hemophilia A
or mild von Willebrand's disease |
|
|
Term
| Factors C and S turn off what ? |
|
Definition
|
|
Term
| Factor 13 deficiency has what clotting profile ? |
|
Definition
Normal PT and PTT and bleeding from umbilical stump
But increase PTT and bleeding from umbilical stump can also be found in Factor 8 deficiency (Hemophilia A) |
|
|
Term
| Memorize Clotting Factors for each coaguability from Wikipedia page |
|
Definition
|
|
Term
| Pulmonary emboli arise from where ? |
|
Definition
| Deep leg veins (femoral vein, iliac vein, popliteal vein) |
|
|
Term
| Vasospasm from cocaine use or smoking can cause what two heart problems ? |
|
Definition
| Prinzmetal's angina and MI |
|
|
Term
| How to treat an untwisted testes ? |
|
Definition
Twist it from midline to out
Vein is occluded first and is always a hemorrhagic infarct |
|
|
Term
| What causes the sudden death in a saddle embolus in like the pulmonary artery ? |
|
Definition
| Right ventricular failure |
|
|
Term
| Where do white (anemic) infarcts occur ? |
|
Definition
| They occur in solid organs with a single blood supply such as spleen, kidney, or heart |
|
|
Term
| Sequence of tissue events after an infarct ? |
|
Definition
Ischemia
Coagulative necrosis
Inflammation
Granulation tissue (Collagen Type 3)
Fibrous scar (Collagen Type 1) |
|
|
Term
| What are the confirmatory tests for DVT and for HIT ? |
|
Definition
Ultrasound for DVT
Serotonin release test for HIT |
|
|
Term
| Know characteristics of TTP and HUS ...see pg. 41 in notes |
|
Definition
|
|
Term
| Deficiency in ADAMTS13 occurs mostly in ? |
|
Definition
|
|
Term
| Do not give what as trt for TTP, ITP, and HUS ? |
|
Definition
|
|
Term
| PT and PTT tests do not measure what factor ? |
|
Definition
|
|
Term
| What are the only two factors made by blood vessels ? |
|
Definition
| Factor 8 and von Willebrand's factor |
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