Term
two toxin-producing bacterial pathogens of the
upper respiratory tract |
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Definition
bordetella spp
haemophilus influenzae |
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Term
| cause of severe whooping cough |
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Definition
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Term
| characteristic of bordetella pertussis |
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Definition
gram negative
stricktly aerobic
obligate human pathogen
slow growing
infects URT
toxin producing
highly contageous (esply in women) |
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Term
| are there vaccine for bordetella pertussis? |
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Definition
two types
pre and post vaccine
(1-3 yo and 18-25 yo) |
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Term
| virulence factors of bordetella pertussis |
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Definition
pili: attatchment to host cells
capsule: antiphagocytic, adherence
filamentous hemagglutinin (glycolipids)
pertacin (binds to host cells) |
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Term
| what toxin does bordetella pertussis produce ? |
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Definition
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|
Term
three stages of infection in bordetella pertussis are:
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|
Definition
incubation stage
catarrhal stage
paroxysmal stage |
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Term
|
Definition
no over symptoms
lasts 7-10 days |
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Term
|
Definition
nonspecific symptoms : malaise, rinorrhea, lacrimation, low grade fecer, anorexia, dry cough
lasts from 7 to 14 days
hightes bacterrial cuture |
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Term
|
Definition
parocysmal "whooping" coughing
tenacious mucus
symptom lasts 1-2 weeks
lymphocytosis |
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Term
| treatment of bordetella pertussis is |
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Definition
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Term
| diagnosis of bordetella pertussisis done by culturing of the bacteria in |
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Definition
VBNC, viable but non-culturable bacteria
cannot use cotton swabs b/c fatty acid in swab kills bacteria |
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Term
| characteristic if Haemophilus influenzae |
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Definition
gram negative
aerobic
grow in heat-treated erythrocytes agar |
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Term
| H. influenzae causes what disease |
|
Definition
URT disease
middle ear infection |
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Term
| virulence factors of H. influenzae |
|
Definition
capsule: secreted polysaccharide coat
pilus: attachment to target cell
HAP protein: promotes intimate adherence
LPS endotocin: inflammatory, impairs ciliary function of URT cells
IgA1 protease: destroys IgA |
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Term
| differenciating strains of haemophilus influenzae is done by examining |
|
Definition
expression of capsular polysaccharide
(A B C D E F) |
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Term
| vaccine for haemophilus influenzae? |
|
Definition
yes, very effective one
so the infections are caused by uncapsulated organisms |
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Term
so the infections are caused by uncapsulated organisms
what organism? |
|
Definition
nontypeable H. influenzae
NTHI |
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Term
| where does NTHI colonize? |
|
Definition
nasopharynx in children
LRT of adults with COPD |
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Term
| a disease associated with NTHI is |
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Definition
otitis media
bacteria migrate from nasopharynx to the inner ear via eustacian tube |
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Term
| another type of Haemophilus that ia correlated with higher probability of contracting a lethal disease is |
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Definition
Hemophilus ducreyi
(genital ulcer disease)
leads to HIV |
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Term
| Helicobacter pylori infection leads to |
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Definition
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Term
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Definition
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