Term
Step 1: (from Ammonia)
Give cellular location
Give Enzyme
Give reactants
Give products |
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Definition
Mitochondria
Carbamoyl phosphate synthetase (CPS1)
NH4++HCO3-+2ATP
Yields
Carbamoyl phosphate (CH2NO5P2-)+ 2ADP+Pi
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Term
Step 2:
Give cellular location
Give Enzyme
Give reactants
Give products
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Definition
Mitochondria
Ornithine transcarbamylase (OTC)
Carbamoyl phosphate (CH2NO5P2-) + ornithine (C5H12N2O2)
yields
Citrulline (C6H13N3O3) +Pi |
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Term
Step 3:
Give cellular location
Give Enzyme
Give reactants
Give products
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Definition
Cytosol
argininosuccinate synthase (ASS)
Citrulline(C6H13N3O3) +aspartate(C4H7NO4)+ATP
yields
arginiosuccinate (C10H18N4O6) + AMP + PPi |
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Term
step 4:
Give cellular location
Give Enzyme
Give reactants
Give products
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Definition
cytosol
Argininosuccinate lyase
Argininosuccinate (C10H18N4O6)
yields
Arginine (C6H14N4O2) + fumarate (C4H4O4) |
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Term
Step 5:
Give cellular location
Give Enzyme
Give reactants
Give products
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Definition
cytosol
Arginase (ARG1)
Arginine (C6H14N4O2) + H2O
yields
Ornithine (C5H12N2O2) + Urea (CH4N2O) |
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Term
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Definition
| N-acetylglutamate as a positive allosteric activator. This is the short term control mechanism for the urea cycle such as following an acute, high protein meal. Formed from acetyl CoA and glutamate. |
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