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UPSOM 2007 B&B Neuroanatomy
Neuroanatomy
75
Medical
Graduate
02/15/2007

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Cards

Term
Anterior Commisure
Definition
connects the temporal lobes
Term
Cingulate Gyrus
Definition
Memory consolidation
Term
Primary motor cortex
Definition
Anterior to the central sulcus in the frontal loba. Sends out axons synapse in brain stem and spinal cord to produce voluntary movement
Term
Premotor/Supplementary motor cortex
Definition
Anterior to primary motor cortex. Modulates movement: slow, fast, jittery, etc.
Term
Frontal Eye fields
Definition
Anterior to the premotor cortex. Important for producing saccades (fast eye movement)-->associated with nystagmus
Term
Prefrontal cortex
Definition
Lateral portion involved in plan formation based on external sensory input. Ventral orbitofrontal cortex is involved in plan formation based on internal criteria such as ethics, morals, hunger, fear, etc.
Term
Broca's Area
Definition
Located in ventral frontal cortex; involved in speech production. Usually left side.
Term
Primary somatosensory cortex
Definition
Posterior to the central sulcus. Receives sensory information via the thalamus
Term
Somatosensory and visual association cortex
Definition
Anterior to the primary somatosensory cortex and superior to the supramarginal and angular gyri. Integrates visual and sensory information. Refines visual information in terms of "where" visual stimuli is located in space.
Term
Supramarginal and angular gyri
Definition
Usually on left side. Important for parts of language comprehension and processing. On the right side they are involved in recognition of the emotional tones of language.
Term
Primary visual cortex
Definition
surrounds the calcarine fissure in the occipital lobe. Recieves visual information from the lateral geniculate nucleus
Term
Higher level visual association areas
Definition
In the occipital lobe on the superior and inferior sides of the primary visual cortex. Involved in further refine visual input into specific characteristics.
Term
Superior Temporal Gyrus
Definition
Just ventral to the lateral fissure. Involved in auditory processing and part of language comprehension
Term
Middle and Inferior Temporal Gyri
Definition
Refine visual information in terms of what the visual stimuli is.
Term
Wernicke's Area
Definition
Located on the posterior portion of the superior temporal gyrus. Important for the comprehension of spoken language
Term
Heschl's Gyrus/Primary Auditory Cortex
Definition
Just inside the later fissure, the gyrus that runs from the temporal pole towards the insula.
Term
Reticular formation
Definition
A network or neurons that regulate levels of arousal and awareness in the brainstem
Term
Superior collicului
Definition
1/2 of the tectum on the dorsal surface of the midbrain

Involved in reflexive head and eye movements

Input:
--Vision: retina, visual cortex
--Audition: Inferior colliculus
--Somatosensation: cortex, spinal cord

Output:
--Tectospinal (head)
--Tectobulbar (eye)
Term
Inferior colliculus
Definition
1/2 of the tectum on the dorsal surface of the midbrain

Also involved in reflexive head and eye movements.

Obligatory relay nucleus of the auditory pathway.

Input-->I.C.-->thalamus-->Primary Auditory Cortex
Term
Vestibulocerebellum
Definition
Consists of the flocculus and the nodulus (the tip of the vermis)
Term
Spinocerebellum
Definition
Consists of the vermis and paravermis. Modulates muscle movement of distal gross muscles (walking) via the paravermis and axial muscles (trunk and girdle) via the vermis.

Note: the tonsils of the paravermis can be forced through the the base of the skull in a tonsilar herniation from increased intracranial pressure.
Term
Cerebrocerebellum
Definition
Regulates fine repetitive movement with regard to its spatial and temporal timing.
Term
ACA blood coverage
Definition
Middle and inferior frontal lobe
Midline parietal lobe
Anterior Corpus Callosum
Term
MCA blood coverage
Definition
Lateral surfaces of all cerebellar lobes
Term
PCA blood coverage
Definition
Medial Occipital Lobe (visual cortex)
Inferior Temporal Lobe
Posterior Corpus Callosum
Term
SCA blood coverage
Definition
Superior cerebellum
Some midbrain
Term
AICA blood coverage
Definition
Dorsal Brainstem
Some CN nuclei
Lateral Pons
Term
PICA blood coverage
Definition
Inferior and Medial Cerebellum
Cerebellar Peduncles
Some CN nuclei
Lateral Medulla
Term
Uncal Herniation
Definition
Compression of
-Cerebral peduncles: descending contralateral motor problems
-and CN III: "Down and out" eye deviation with ptosis and pupil dilation (from loss of PS innervation of pupillary sphincter muscle)
Term
Lenticulostriate arteries location and blood coverage
Definition
Small penetrating branches from MCA.
Supply
-Putamen
-Globus Pallidus
-part of the internal capsule
-body of caudate
Term
Thalamoperforator arteries location and blood coverage
Definition
Come off tip of basilar/PCA junction
Supply
-thalamus
-subthalamus
Term
Clinical of significance of the lenticulostriate arteries
Definition
-Very sensitive to hemorrhage from unctrolled hypertension

-Lenticulostriate end zone doesn't have any collateral circulation and thus is sensitive to stroke: This is the first part of the brain to lose perfusion during stroke or heart attack. Leads to signs of contralateral hemiparesis and hemi-sensory loss
Term
Dorsal Columns/Funiculus
Definition
AKA Dorsal columns.

Divided into Fasciculus Gracilis and Fasiculus Cuneatus

Ascending tracts only: the DCML tract

Light touch, joint positions, and vibration sensory axons

Lesions cause an ipsilateral deficit
Term
Anteriolateral System/Funiculus
Definition
AKA the Spinothalamic Tract
Ascending tracts; cross in Lissauer's tracts.

Heavy Pressure, pain and temperature

Lesion imparts contralateral symptom loss several segments below the lesion.
Term
Lateral Funiculus
Definition
Descending: Lateral Corticospinal and Rubrospinal Tracts

Ascending: DSCT and VSCT

-Both DSCT and VSCT carry cutaneous info, muscle length and tension, and joint position to the cerebellum
-VSCT also carries copies of the commands sent to the muscles by motorneurons.
-DSCT axons ascend ipsilaterally
-VSCT decussate upon entering the cord and than again before entering the cerebellum
Term
Ascending Spinal Tracts Location overview
Definition
Dorsal Funiculi/Columns:
-DCML split into F.C and F.G.
----Light Touch, Joint Position, Vibration
----Ipsilateral ascension

Lateral Funiculus:
-DSCT: ipsilateral ascension
-VSCT: contralateral ascension


"Anteriolateral System"
-STT
----Heavy Touch, pain, and temperature
----Delayed Contralateral ascension
Term
3 Forebrain components of the basal ganglia
Definition
Caudate, putamen, and globus pallidus

Striatum= Caudate + Putamen

Lentiform Nucleus= Putamen + Globus Pallidus
Term
Caudate
Definition
Head is in the frontal lobe
Body is along the lateral wall of the lateral ventricle
Tail is curved into the temporal lobe

Many direct connections with frontal lobes. Involved in dementia in Huntington's and tics in Tourette's.
Term
Putamen
Definition
Separated from the Caudate by the anterior limb of the Internal Capsule.

Separated from the Thalamus by the posterior limb of the Internal Capsule

Input from cortex and others.
Output to the globus pallidus
Term
Globus Pallidus
Definition
Medial to the Putamen and lateral to the Internal Capsule.

Internal/External can be seen in stained sections
Term
3 Basal forebrain nuclei
Definition
Midline nuclei in the ventromedial frontal lobe

Nucleus Accumbens
Nucleus Basalis of Meynert
Septal Nuclei
Term
Nucleus Accumbens
Definition
Located where caudate and Putamen aren't separated by the internal capsule

Reward center; a lot of opiod receptors
Term
Nucleus Basalis of Meynert
Definition
Seen in coronal sections ventral to the anterior commisure

Important for memory. Cholinergic neurons projected into many cortical areas. Degenerates in Alzheimers.
Term
Septal Nuclei
Definition
Located anterior to the anterior commisure at the bottom of the septum pellucidum

Lateral: limbic input ie: amygdala
Medial: Associated with memory structures such as the hippocampus
Term
Limbic system Function and structures
Definition
Controls mood and evaluation of external circumstances. Controls emotional aspect of memory.

Associated structures include: amygdala, hippocampus, hypothalamus, cingulate gyrus and basal forebrain nuclei
Term
Amygdala
Definition
Located on the most anterior portion of the temporal horn the lateral ventricle

Comprises of many small nuclei which communicate with the hypothalamus and basal forebrain

Involved in motivation, context of memory,, other complex behaviors.
Term
Kluver Bucy syndrome
Definition
Lesions to Amygdala result in

visual/tactile/auditory agnosia

hyperorality and hyperphagia

hypersexuality
Term
Types of Memory
Definition
Remote
Declarative
Procedural
Recent
Working
Term
Hippocampus and Fornix
Definition
Located in the medial wall of the temporal horn of the lateral ventricle

An axon bundle called a fornix that splits at the anterior commisure

Pre commissural fibers synapse on medial septal nuclei of the basal forebrain.

Pre commissural fibers synapse on the mammillary bodies of the hypothalamus.

Important for the formation of recent memories
Term
HM's symptoms from hippocampus removal
Definition
Permanent Anterograde Amnesia: Inability to lay down new memories while preserving past memories.

Unable to to convert working memories into recent memories

Could still build new procedural memories.
Term
4 divisions of the diencephalon
Definition
Thalamus (dorsal anterior)
epithalamus (dorsal posterior)
----hypothalamic sulcus-------
hypothalamus (ventral anterior)
subthalamus (ventral posterio)
Term
Hypothalamus
Definition
Many small nuclei that communicate with the pituitary to control eating, sex, reproduction, and others.

Ventral surface includes
optic chiasm
infidibulum
mammillary bodies
Term
Mammillary bodies
Definition
Memory structures

Input: Post comm. Hippocampal fornix
Output: Mammillary tracts to anterior nucleus of thalamus

Hippocampus-->fornix-->M.B.-->M. tracts-->AN of thalamus
Term
Thalamus
Definition
Relay nuclei to the cortex from other areas.

Anterior Nucleus
Ventral Anterior/Ventral Lateral Nucleus
Ventral Posterolateral Nucleus
Ventral Posteromedial Nucleus
Medial Geniculate Nucleus
Lateral Geniculate Nucleus
Term
Anterior Nucleus (AN)
Definition
Small bump in the floor of the lateral ventricle.

Input: mammillary bodies via mammillothalamic tract

Output: axons to the Cingulate Gyrus
Term
Ventral Anterior/Lateral Nucleus (VA/VL)
Definition
Seen in stained sections
Connections with the motor cortex and basal ganglia.
Help modulate movement
Term
Ventral Posterolateral Nucleus (VPL)
Definition
Seen in stained sections. Large

Input: sensory from DCML and the STT (anterolateral system)
Output: ?Somatosensory cortex?
Term
Ventral Posteromedial Nucleus (VPM)
Definition
Seen in stained sections just medial to VPL

Input: Sensory from CN V (Trigeminal)
Output: ?Somatosensory Cortex?)
Term
Medial Geniculate Nucleus
Definition
At the border between diencephalon and mesencephalon. At the same horizontal level as the superior colliculi

Input: ???
Output:Auditory Cortex

Involved in auditory processing
Term
Pinealomas
Definition
Mass effect pushes down on the superior colliculus. Deep to them are eye movement centers that when damaged lead to Parinaud's syndrome. Hydrocephalus is also caused due to compression of the cerebral aqueduct.

Upgaze paralysis with occasional pupillary abnormalities, loss of convergence, and retractory nystagmus.
Term
Pineal Gland
Definition
Part of the epithalamus. Hangs off of the back of the diencephalon, just under the splenium of the corpus callosum.

Communicates with the hypothalamus to regulate circadian rhythms. Releases melatonin.
Term
Subthalamic Nucleus
Definition
Cat Eye shaped. In the most caudoventral portion of the diencephalon at the border with the midbrain. Also touches the posterior limb of the internal capsule

Communicates with the globus pallidus to modulate movement

Damage from causes contralateral hemiballismus. A target for deep brain stimulation (leading to inactivation) in treatment of Parkinson's Disease
Term
Anterior Commisure
Definition
Splits the globus pallidus and connects the anterior portions of the two temporal lobes
Term
Posterior Commisure
Definition
connects brainstem nuclei associated with eye movements
Term
Tracts running in the Anterior Limb of the Internal Capsule
Definition
-Anterior Thalamocortical Tracts
-Frontopontine Tracts
Term
Tracts running in the Genu of the Internal Capsule
Definition
Corticobulbar Tract
Term
Tracts running in the Posterior Limb of the Internal Capsule
Definition
-Corticospinal Tract
-Rubrospinal Tract
-Central Thalamocortical tracts
-Occipitopontine tracts
Term
Mammillothalamic tract
Definition
Runs from the mammillary bodies to the Anterior Nucleus of the thalamus.

Important in memory and learning.
Term
Optic Radiations
Definition
Runs from the Lateral Geniculate Nucleus and projects to the primary visual cortex

Two different groups of projections

1.Temporal (Meyer's Loop): Terminate on inferior bank of the calcarine fissure; contain superior visual field info.

2.Parietal: Terminate on superior bank of the calcarine fissure; contain inferior visual field info.
Term
Arcuate Fasciculus
Definition
Connects Wernicke's Area with Broca's Area

Lesion imparts conduction aphasia, a disconnection between speech comprehension and motor output.
Term
Uncinate Fasiculus
Definition
Connects the temporal and frontal lobes
Term
Cingulum Bundle
Definition
Group of white matter association fibers that run just beneath the gray matter of the cingulate gyrus

Connection the cingulate gyrus to the parahippocampal gyrus...
Term
Red Nucleus
Definition
Seen at the level of the superior colliculus in BRAINSTEM sections

Involved in gross flexion of the upper body.
Term
Locus Ceruleus
Definition
Runs along the medial edges of the fourth ventricle.

Produces neuroepinephrine
Term
Tectospinal Tract
Definition
Reflexive orientation of the head.

superior colliculus-->immediate tegmental decussation-->ventral to Medial Longitudinal Fasciculus (Brainstem)-->ventromedial spinal funiculus-->synapse on LMN at cervical levels
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