Term
| Beta-lactamase inhibitors |
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Definition
| clavulanate, sulbactam, tazobactam |
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Term
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Definition
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Term
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Definition
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Term
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Definition
beta-lactam, kils almost all gram- types
ex: aztreonam |
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Term
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Definition
beta-lactam, broad spectrum
ex. imipenam, meropenam,
resistant to ESBLs
cilistatin- dihydropeptidase inhibitor (blocks degredation in kidney of imipenam, mero is resistant) |
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Term
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Definition
affects crosslinking at step before beta-lactams
ex. vancomycin, telavancin,
all gram+s
cidal |
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Term
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Definition
benzene rings, binds to 30s, blocks t-RNA. Static, broad
ex: tetracycline (itself), doxycycline - better oral absorption |
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Term
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Definition
irreversibly bind 30s subunit
bacteriocidal
gram-
ex:gentamicin, streptomicin, kanamicin |
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Term
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Definition
| fading of normal basophilia of nuclei |
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Term
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Definition
| increase in basophilia w/ nuclear shrinking |
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Term
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Definition
| frangmentation and dispersion of necrotic nucleus |
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Term
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Definition
| is a lincosamide, anaerobes, inh 50s, static. |
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Term
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Definition
| static- 50s- MRSA and VancoResist Enterococci (narrow spectrum) |
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Term
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Definition
more gram+ than gram-, blocks 50s, static
ex. erythro-mycin azithro- clarithro- telithro- (ketolide) |
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Term
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Definition
quinupristin/dalfopristin, used in combo.
cidal, VRE/MRSA, 50s |
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Term
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Definition
inhibit dna gyrase, cidal
ex. cipro-floxacin, nor-, a-
fluorine added helps prevent excretion in urine |
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Term
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Definition
| inh RNA pol, cidal, gram+ |
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Term
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Definition
| ex. Sulfamethoxazole, Para amino benzoic acid (PABA) analog, static, combo w/trimethoprim, broad |
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Term
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Definition
| dihydrofolate reductase inhibitor, broad, in combo with sulfas, static |
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Term
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Definition
| ethanolamine derivative, benadryl, antimusccarinic effects, sedation |
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Term
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Definition
| ethylendiamine, otc "sleep aid" |
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Term
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Definition
| piperazine deriv, anti-motion sickness |
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Term
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Definition
| phenothiazine deriv, antimuscarinic, antiemetic |
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Term
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Definition
| less sedating, common cold medication |
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Term
| ioratidine and fexofenadine |
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Definition
| piperidine derivatives (2nd gen), no sedation, but poor bbb crosser |
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Term
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Definition
| 2nd gen, intranasal and ophthalmic |
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Term
| Famotidine and Nizatidine |
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Definition
H2 receptor antagonists, block gastric acid especially nocturnally
others: cimetidine, ranitidine but these have p450 effects, liver toxicity or antiandrogen effects |
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Term
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Definition
| antagonist to H1 and 5-HT2, urticaria and diarrhea from serotonin tumor |
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Term
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Definition
| 5-HT2a,2c antagonist, a1-adrenergic and h1 blocker, antihypertensive, antagonizes platelet aggregation |
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Term
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Definition
| 5-ht3 ant, nausea from chemo |
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Term
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Definition
| 5-HT1,2 agonist, some adrenergic affects, prodrome of migraine, combined with caffeine tox: NV, vasoconstriction |
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Term
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Definition
| 5-HT1 part. agonist, 5-HT2 ant. headache prophylaxis. toxL gi, infl fibrosis, hallucinations. not in US |
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Term
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Definition
| suma- riza- nara-, zolmi-, non-ergot serotonin analogs, 5-HT1b,1d agonists, acute migraine relief. mech: act 1b,d recpetors in cerebral BV->vasoconstriction, stim on trigem inhibits pro-infl cytokines |
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Term
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Definition
| postpartum hemorrhage, sustain uterine stimulation |
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Term
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Definition
| d2 agonist, suppresses prolactin secretion from pituitary cells |
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Term
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Definition
irreversibly blocks eicosanoid synth by acetylating COX-1/2
salicylic acid reversibly inhibits cox1/2 |
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Term
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Definition
| competitive inh of cox1/2, longer t1/2 and better GI than aspirin |
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Term
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Definition
| para-amino phenol, poor ability to bind cox @ inflammation, disproportionately high activity in brain->antipyretic |
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Term
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Definition
indomethacin, 10x more potent than aspirin, toxicity limits use->headaches, anemia, thrombocytopenia
sulindac, 1/2 as potent as indometh, less side effects |
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Term
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Definition
ibuprofen
flurbiprofen, synovial concentration, opthalmic
naproxen, 20x aspirin, t1/2 13 hrs
oxaprozin, t1/2 50 hrs |
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Term
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Definition
| enolic acid, arthritis, t1/2 45hrs |
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Term
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Definition
| heteroaryl acetic acid, IM, t1/2 4-6 hrs, analgesic=opioids, ophthalmic |
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Term
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Definition
| celecoxib, etoricoxib - older ones caused mi, stroke, thrombosis |
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Term
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Definition
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Term
| Concentration at Steady State |
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Definition
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Term
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Definition
| = Vd (Cp desired- Cp initial into Vd) |
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