Term
| Major cells involved in innate immunity? |
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Definition
| Monocytes, macrophages, neutrophils, NK cells |
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Term
| Cells involved in cell mediated immune response? humoral immunity? |
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Definition
T lymphocytes
B lymphocytes |
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Term
| Primary phagocytic cell in acute inflammation? |
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Definition
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Term
| Type of cell necessary for transplant rejection? |
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Definition
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Term
| Which cells contain myeloperoxidase and lysozyme? |
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Definition
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Term
| Cell that is a major mediator of a type I hypersensitivity reaction? |
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Definition
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Term
| Major mediator of the antiparasitic response? |
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Definition
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Term
| Which cells have granules containing histamine and heparin? |
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Definition
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Term
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Definition
| macrophages, dendritic cells, and B cells |
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Term
| Which cells have a multilobed nucleus in Vit B12 or folate deficiency? |
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Definition
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Term
| Which cells secrete IL-1 to promote T cell activity? |
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Definition
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Term
| Which cells express IgE receptors on its cell membrane to mediate the allergic response? |
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Definition
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Term
| Which cells express high levels of MHC Class II on its cell membrane? |
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Definition
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Term
| Which cell is a macrophage precursor? |
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Definition
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Term
| Which cell type is increased in atopic asthma? |
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Definition
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Term
| Which cell recognizes antigen presented in the context of MHC Class II molecules? |
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Definition
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Term
| Antibody producing cell with abundant RER? |
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Definition
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Term
| Which cells are a major source of IL-2 production? major cells of the humoral immune response? |
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Definition
T helper cells (Th1)
B lymphocyte |
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Term
Name the type of Immunoglobulin (Ig):
1. most abundant type
2. able to fix complement
3. able to cross the placenta
4. responsible for long term immunity |
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Definition
1. IgG
2. IgG and IgM
3. IgG
4. IgG |
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Term
Name the type of Ig:
1. 1st class of Ig produced in an immune response upon exposure to an antigen?
2. found on the lining of mucous membranes and in secretions like breast milk and saliva?
3. type commonly occuring as a dimer?
4. type commonly occuring as a pentamer? |
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Definition
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Term
Name the type of Ig:
1. elevated in patients with asthma and allergies?
2. causes mast cells and basophils to release histamine when triggered by Ag?
3. Type found embedded in the cell membrane of developing B cells?
4. total levels and concentration of this Ab can be estimated using a radioimmunosorbent test (RIST) and radioallergosorbent test (RAST)? |
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Definition
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Term
| What term is used to describe the portion of a molecule that serves as an antigenic determinant? |
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Definition
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Term
| What term is used to describe a small molecule that can serve as an antigenic determinant only if it is attached to a larger carrier molecule> |
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Definition
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Term
| What type of chemical bonds are critical in linking the heavy and light chains of Ig's? |
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Definition
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Term
| Which product results when papain digests an Ig? |
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Definition
| Two Fab fragments capable of binging Ag and one Fc fragment |
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Term
| Which products are produced following pepsin digestion of an Ig? |
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Definition
| One F(ab')2 fragment and one Fc fragment |
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Term
| What term is used to describe the region in an antibody that determines Ag specificity? |
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Definition
| the hypervariable region or complementarity determining region (CDR) |
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Term
| Name five mechanisms of antibody diversity? |
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Definition
1. mutations in the genes encoding the CDR region
2. random VJ recombination in light chains
3. random VDJ recombination in heavy chains
4. random assembly of light and heavy chains
5. imperfect recombination of VDJ genes |
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Term
Name the T lymphocyte cell surface protein associated with the following features:
1. Ag specific receptor on 95% of T cells
2. Ag specific receptor on 5 % or less of T cells
3. signal transduction protein always associated with TCR
4. T cell marker expressed in immature T cells
5. responds to MHC II class II molecule expressed by Ag presenting cells |
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Definition
1. alphaBeta T cell receptor (TCR)
2. gammaDelta T cells receptor
3. CD3
4. CD2
5. CD4 |
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Term
Name the T lymphocyte cell surface protein associated with the following features:
1. responds to MHC class I molecules expressed on all cells
2. found specifically on T helper cells
3. found specificall on cytotoxic T cells
4. cells with this surface marker decrease in HIV/AIDS
5. type of T cells that destroys virally infected cells |
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Definition
1. CD8
2. CD4
3. CD8
4. CD4
5. CD8 |
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Term
Name the HLA haplotypes associated with the following diseases:
1. ankylosing spondylitis
2. type I diabetes mellitus
3. multiple sclerosis
4. rheumatoid arthritis
5. screening for abacivar hypersensitivity |
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Definition
1. HLA-B27
2. HLA-DR3/DR4
3. HLA-DR2
4. HLA-DR4
5. HLA-B*5701 |
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Term
Name the cytokine:
1. endogenous pyrogen
2. promotes IgA synthesis
3. induces Il2 production by T cells
4. high concentrations induce cells death in some tumors and cause cachexia
5. induces T and B cell activity during the intial stages of an immune response |
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Definition
1. IL-1 from macrophages
2. IL-5
3. IL-1
4. TNF-alpha
5. IL-1 |
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Term
Name the cytokine:
1. induces production of IgE and IgG
2. induces differentiation of eosinophils and promotes growth of B cells
3. chemotactic factor for neutrophils
4. secreted by activated T cells and induces maturation of bone marrow stem cells
5. inhibits production of interferon gamma by T helper cells
6. inhibits production of IFN-y |
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Definition
1. IL-4 from T helper cells
2. IL-5 from T helper cells
3. IL-8 from monocytes and endothelial cells
4. IL-3
5. IL-10 from TH2 cells
6. Il-4 |
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Term
Name the cytokine:
1. inhibits differentiation of Th1 cells
2. stimulates Th1 differentiation
3. activates T helper, cytotoxic T and NK and B cells
4. promotes production of IFN-y T helper cells
5. low concentrations promote neutrophil activity and IL-2 receptor expression
6. inhibits grwoth and function of T and B cells and promotes collagen secretion during tissue repair |
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Definition
1. IL-10
2. IL-12 from macrophages and B cells
3. IL-2 from T helper cells
4. IL-12
5. TNF-alpha
6. TGF-Beta |
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Term
Name the gel and Coombs Hypersensitivity reaction:
1. medaited by IgE bound to mast cells and basophils
2. antibody mediated cytotoxis reaction
3. occurs in response to environmental allergens
4. Ag-sensitized T cells release cytokines, which induce an inflammatory response up to 48 hours after initial contact with AG |
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Definition
1. Type 1
2. type 2
3. type 1
4. type 4 |
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Term
Name the Gel and Coombs Hypersensitivity reaction:
1. assocaited with release of histamine, platelet activating factor, leukotrienes, prostaglandins, thromboxanes
2. binding of cytotoxic T cells or complement to Fc portion of antibody causes target cell lysis
3. immune complex deposition in tissues results in an immflammatory response |
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Definition
1. type 1
2. type 2
3. type 3 (immune complex reaction) |
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Term
What is a type ___ reaction?
1. type 1
2. type 2
3. type 3
4. type 4 |
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Definition
1. immediate or anaphylactic
2. cytotoxic
3. immune complex
4. delayed type |
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Term
Name the type of hypersensitivity reaction responsible for the following disease/conditions:
1. arthus reaction
2. asthma
3. chronic transplant rejection
4. contact dermatitis, poison ivy rxn
5. drug allergies
6. environmental allergies
7. erythroblastosis fetalis
8. goodpasture syndrome |
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Definition
1. type 3
2. type 1
3. type 4
4. type 4
5. type 1
6. type 1
7. type 2
8. type 2 |
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Term
Name the hypersensitivity reaction:
1. Graves disease
2. hemolytic anemia
3. immune complex-mediated glomerulonephritis
4. Lambert-eaton
5. myasthenia gravis
6. Multiple sclerosis
7. pernicious anemia |
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Definition
1. type 2
2. type 2
3. type 3
4. type 2
5. type 2
6. type 4
7. type 2 |
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Term
Name the hypersensitivity reaction:
1. purified protein derivative (PPD)/tuberculin test
2. rheumatic fever
3. rheumatoid arthritis
4. systemic anaphylaxis
5. serum sickness
6. SLE
7. transfusion reaction due to ABO incompatibility |
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Definition
1. type 4
2. type 2
3. type 3
4. type 1
5. type 3
6. type 3
7. type 2 |
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Term
| which class of bacteria is particularly susceptible to complement mediated lysis? |
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Definition
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Term
| which AB isotypes activate the classic pathways of complement? |
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Definition
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Term
| which molecules activate the alternative pathway of the complement cascade? |
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Definition
| aggregated IgA, endotoxin, and other components of bacterial cell walls |
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Term
Name the components of the complement cascade responsible for:
1. neutralization of viruses
2. opsonization
3. neutrophil and macrophage chemotaxis
4. synthesis of the MAC
5. formation of C3 convertase |
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Definition
1. c1-C4
2. C3b
3. C5a
4. C5b to C9
5. C3b, Bb (alternative) or C4b, C2b (classic) |
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Term
Name the disease or condition cause dby a deficiency of:
1. c1 esterase inhibitor
2. C3
3. C5b-c9
4. decay accelarating factor (DAF) |
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Definition
1. hereditary angiodema
2. sinus and upper respiratory tract infections
3. recurrent Neisseria infections
4. paroxysmal nocturnal hemoglobinuria |
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Term
Name the type of transplant rejection:
1. preformed AB's in host react against graft Ag's
2. activation of previously sensitized T cells
3. involves T cell activation, differentiation and Ab production
4. immune complex deposition combined with subacute cell cytotoxicity |
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Definition
1. hyperacture rejection (minute-hours)
2. accelerated rejection (hours to days)
3. acute rejection (days-weeks)
4. chronic rejection (months-years) |
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Term
| What are the 4 different classes of grafts? |
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Definition
1. autograft (self)
2. syngeneic (identical twin or clone)
3. allograft (same species)
4. xenograft (different species) |
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Term
The activity of cytotoxic T cells against:
1. virally or tumor inefected cells requires which cell surface receptor for Ag presentation?
2. against pathogens phagocytosed by macrophages requires which cell surface resceptor for Ag presentation? |
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Definition
1. MHC class I
2. MHC class II |
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