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UMB Pediatric Pharmacology - GERD
P3 - Exam 1
22
Pharmacology
Professional
10/02/2016

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Cards

Term
Define GERD
Definition
pH < 4 in esophagus for >15 sec
Term
Classifications of GERD
Definition
1. Physiologic
2. Functional
3. Pathogenic (FTT)
4. Secondary unresponsive to treatment
Term
Symptoms of reflux
Definition
1. Emesis
2. Esophagitis
3. Infant spells (presents seizure-like)
Respiratory
4. Sandifer's syndrome (neck tilting)
Term
Why is reflux more common in infants?
Definition
1. Slowed gastric emptying
2. LES pressure is less
3. Esoph. Peristalis
Term
What is the gold standard dx of GERD
Definition
1. pH probe
Term
What are 3 methods to dx GERD?
Definition
1. Barium swallow
2. Biopsy
3. Intra-esoph pH monitor (pH probe)
Term
Nonpharm treatment of GERD
Definition
1. position change
2. Avoid second-hand smoke
3. Alter feeding
4. Avoid some foods
Term
What type of foods should be avoided in GERD?
Definition
1. Foods that decrease LES tone
2. Foods that in gastric acid (fatty, citrus, tomato, coffee, soda, alcohol
Term
What type of meds should be avoided in GERD?
Definition
1. anticholinergics
2. xanthines(caffeine)
3. CCB
4. prostaglandins (NSAIDS)
Term
How can feeds be altered to treat GERD?
Definition
1. Thicken with rice
2. Smaller portions
3. Change formula type to soy or elemental
Term
Describe the Nissen Fundoplication surgery
Definition
Wrap stomach around the espoh. to increase pressure
Term
First-line med for GERD and typical dosing in PEDs?
Definition
H2 (ranitidine, famotidine)
Start aggressive 8-10mg/kg/day
Term
What is the common duration of pharm treatment in peds for GERD?
Definition
~6mo and then wean as LES has likely gotten stronger, and the meds are no longer needed
Term
T/F there is evidence for treating infants with PPI?
Definition
False
Term
When should a PPI be administered?
Definition
30min before meal.
Do not worry about first feeding of the day or middle of the night feeding.
Term
Where is Erythromycin's place in peds GERD treatment?
Definition
Older kids | other treatments failed
Term
What is a side effect of Bethanechol?
Definition
Wheezing
Term
What prokinetic agents are available for treating peds GERD?
Definition
Bethanechol
Erythromycin
Metoclopramide (no longer used)
Cisapride(discontinued)
Term
CASE 1: 4mo presents to pharmacy. Cranky all the time. No fever. what questions need to be asked?
Definition
1. How long?
2. Teething?
3. Describe feeding
4. Describe bowel movements
5. Describe vomitting
6. Medications?
7. GERD symptoms?
Term
Describe GERD esophagitis symptoms
Definition
1. chest pain
2. Irritability
3. Feeding trouble
4. Anemia
5. Hematemesis
6. Esoph obstruction
Term
Describe GERD respiratory symptoms
Definition
1. recurring pneumonia
2. Wheezing
3. Apnea
4. Stridor
5. Cough
6. Hiccups
Term
Case 1: Baby has signs of GERD (cries after feeding turns head away, arches back while feeding, spit-up w/ crying) Hieght/weight are normal
Definition
Star with non-pharm
1. thicker feeds
2. smaller feeds
3. change formula type
3.
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