Term
|
Definition
| Antibody-dependent cytotoxicity |
|
|
Term
| What is Goodpasture's syndrome? |
|
Definition
| autoantibodies develop to lung and glomerular basement membranes |
|
|
Term
| How does recruitment and activation begin? |
|
Definition
Ig M and G attach to host cell
fixation of complement
PMN's attracted to site |
|
|
Term
| What is a result of complement activation in type II |
|
Definition
| lysis of cells and damage to tissues |
|
|
Term
| How is phagocytosis activated in type II |
|
Definition
| Ab and C3b opsonize cells and causes phagocytosis of those cells. |
|
|
Term
|
Definition
| Ab's are targeted toward viruses inside the host cell, killing it also. via NK cells |
|
|
Term
| Other than NK cells, what else mediates ADCC |
|
Definition
| IgE and IgG + eosinophils. |
|
|
Term
| How do epitopes work in type II |
|
Definition
| binding to a hapten causes immune system to recognize it as foreign eliciting an Ab response |
|
|
Term
| What are the 3 etiologies of Type 3 injury? |
|
Definition
Persistent Infection
Autoimmune Disease
Inhalation of antigenic material |
|
|
Term
| What does type III injury require? |
|
Definition
| Ag-Ab complexes w/complement activation |
|
|
Term
| What do macrophages release in type III? |
|
Definition
|
|
Term
| what are the pathologic hallmarks of type III injury |
|
Definition
| necrosis, neutrophil infiltrate |
|
|
Term
| what are the ab's involved in type 3 |
|
Definition
|
|
Term
| These cause the release of vasoactive amines in mast cells |
|
Definition
|
|
Term
| What is the Arthus reaction? |
|
Definition
Ag inoculated who previously sensitized person
insoluble Ag-Ab complex forms
complement activation
PMN's attract
rxn 4-6 hours |
|
|
Term
|
Definition
| Th1 secrete IFN-y activate macrophages which secretes TNF-a, the MAJOR mediator |
|
|
Term
| What is the Classic DTH skin test |
|
Definition
|
|
Term
| What does contact dermatitis result from? |
|
Definition
| binding of haptens to skin proteins eliciting response |
|
|
Term
| Response cells of Contact dermatitis |
|
Definition
CD8 and CD4 response.
sensitizes individual first w/no effect! |
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