Term
| Type 1 hypersensitivity characterization |
|
Definition
IgE mediated
initial sensitization
adaptive immune response |
|
|
Term
| How are mast cells activated? |
|
Definition
| cross-linking of Fc receptor bound by IgE |
|
|
Term
| What does allergic sensitization require? |
|
Definition
| initial exposure that generates an adaptive immune response |
|
|
Term
| what are the immediate inflammatory mediators released |
|
Definition
| histamine, tryptase and TNF-a |
|
|
Term
| What is released after the immediate mediators? |
|
Definition
| leukotrienes, prostaglandins, and cytokines= LATE RESPONSE |
|
|
Term
| These are recruited to the site in Late phase |
|
Definition
|
|
Term
|
Definition
|
|
Term
| How do mast cells present immaturely? |
|
Definition
|
|
Term
| what are the granule associated mediators |
|
Definition
| histamine, tryptase, chymase carboxypeptidase, heparin |
|
|
Term
| What are the lipid dervied mediators |
|
Definition
PGD2- mast cells
Leukotrienes
Platelet activating factor |
|
|
Term
| these mast cells produce tryptase |
|
Definition
|
|
Term
|
Definition
|
|
Term
| What is the difference b/t basophils and mast cells? |
|
Definition
| basophils do NOT produce PGD2 |
|
|
Term
|
Definition
| bone marrow derived granulocytes |
|
|
Term
| Eosinophil mech of action |
|
Definition
cytotoxic direct killer
slow induction of other mediators |
|
|
Term
| resting Eosinophils express Fc Ri receptor. T/F? |
|
Definition
|
|
Term
| what are hypereosinophilic syndromes complicated by |
|
Definition
| neuropathy and endomyocardial damage |
|
|
Term
| Which histamine receptr causes the allergic effects? |
|
Definition
|
|
Term
| This enzyme is used as a marker of mast cell degranulation |
|
Definition
|
|
Term
|
Definition
inflammation
cytokine secretion
enothelium activation
recruits leukocytes to inflamed tissues |
|
|
Term
| This is more potent than histamine in the late phase |
|
Definition
|
|
Term
| characteristics of allergens |
|
Definition
Proteins
low dose sensitization
low molecular wt.
high solubility
Stable |
|
|
Term
|
Definition
| unanticipated IgE event that does require sensitization |
|
|
Term
| Quick relievers of Asthma |
|
Definition
short-acting b2 agonist
anticholinergics
corticosteroids |
|
|
Term
|
Definition
|
|
Term
| Quick relievers of Asthma |
|
Definition
short-acting b2 agonist
anticholinergics
corticosteroids |
|
|
Term
| Angioedema results in mediator release where? |
|
Definition
|
|
Term
|
Definition
| specific IgE toward allergen |
|
|
Term
|
Definition
shifts IgE to IgG
increased production of IL-10
induction of Treg cells |
|
|
