Term
PDGFB
Platelet derived growth factor |
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Definition
| Overexpression of a growth factor, autocrine loop |
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Term
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Definition
Growth factor receptor
Breast carcinomas |
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Term
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Definition
Growth factor receptor
MEN2A, MEN2B, sporadic medullary thyroid carcinoma |
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Term
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Definition
Growth factor receptor
Gastrointestinal stromal tumor |
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Term
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Definition
Signal transducer (from membrane to the nucleus via GTP binding protein)
Mutated Ras inhibits the activity of GTPase activating protein (wont shut off from GTP to GDP)
Carcinomas, melanoma, and lymphoma |
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Term
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Definition
Signal transducer (from membrane to the nucleus via tyrosine kinase)
CML and some types of ALL
t(9;22) with BCR |
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Term
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Definition
Nuclear regulator (upregulates genes, and growth promoting proteins via transcription factor)
Burkitt Lymphoma
t(8;14) involving IgH |
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Term
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Definition
Nuclear regulator (upregulates genes, and growth promoting proteins via transcription factor)
Neuroblastoma |
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Term
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Definition
Nuclear regulator (upregulates genes, and growth promoting proteins via transcription factor)
Lung carcinoma (small cell) |
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Term
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Definition
Cell cycle regulator (proteins that assist in movement through the cell cycle)
Mantle Cell lymphoma
t(11;14) involving IgH |
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Term
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Definition
Cell cycle regulator (proteins that assist in movement through the cell cycle) via Cyclin-dependent kinase
Melanoma for example |
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