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Tumor markers
aa
9
Chemistry
Pre-School
01/29/2014

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Term
Free PSA
Definition
< 4 ng/mL is healthy. Varies.
>25% free PSA.
Prostate cancer correlation.
Term
AFP
Definition
hepatoma, some ovarian and testes.
Term
CEA clinical utility
Definition
Secreted by various including breast, lung, colorectal, and stomach cancers. Mainly used to monitor recurrence of cancer but it is a useful marker for colorectal cancer. NOt a screening tool
Term
Thryoglobulin (tumor marker)
Definition
check for recurrence after surgery. It is elevated in grave's disease, and thryoditis. Anti thyroglobulins are also screened.
Term
Neuron specific enolase
Definition
glycotic enzyme. Formed in neuroendocrine system, and it is elevated in neuroblastoma and small lung cancer.
Term
calcitonin
Definition
polypeptide hormone, made by C cells in thryoid to regulate calcium. Elevated in thyroid medullary carcinoma. Helps diagnosis, monitor treatment, and reccurence.
Term
H factor. Nuclear matrix protein
Definition
Bladder tumor marker
Term
Her-2/neu gene
Definition
oncogene product (genetic marker). Breast cancers mainly followed by GI and ovarian.
Term
HCG
Definition
Unique Beta subunit. Elevated in germ cell cancers, trophoblastic, and others.
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