Term
| How does an AP cause CA2+ release? |
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Definition
| A voltage sensitive protein in the T-tubules is linked to a Ca2+ channel protein in the SR. APs cause a conformational change in the protein allowing Ca2+ to flow out of the SR into the myofibril cytosol. |
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Term
| What is the thin filament composed of? |
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Definition
1) Troponin
2) Actin
3) Tropoyosin |
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Term
| What is the thick filament composed of? |
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Definition
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Term
| How does calcium facilitate muscle contraction? |
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Definition
1) Binds to troponin
2) This induces a conformational change in tropomyosin to expose the active site on actin
3) Myosin heads bind to actin forming crossbridges
4) Heads move. |
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Term
| What substances are required for the formation of a crossbridge? |
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Definition
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Term
| What substance is required for the dissociation of a crossbridge? |
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Definition
| ATP whic his partially hydrolysed to ADP and Pi. |
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