Term
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Definition
amt of substrate u need to use half of the enzymes
lower Km = higher affinity |
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Term
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Definition
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Definition
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Term
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Definition
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Term
| rapidly dividing cells have a shorter… |
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Definition
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Term
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Definition
| synth excr proteins & add n-linked oligosacchs |
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Term
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Definition
RER in neurons
not in axon or hillock
synth proteins like ChAT & peptide neurotrans |
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Term
| synth excr proteins & add n-linked oligosacchs |
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Definition
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Term
RER in neurons
not in axon or hillock
synth proteins like ChAT & peptide neurotrans |
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Definition
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Term
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Definition
steroid synth
detox drugs & poisonsesp hepatocytes & adr cortex |
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Term
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Definition
1-distr proteins from ER-> membr, lyso, vesicles
2-mod n-oligos on asp
3-adds O-oligos to ser & thr
4- proteoglycan assembly
5-sulfate sugars in proteoglycans & tyr proteins
6-add mann-6-phos to target to lysosomes |
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Term
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Definition
fail to add mann-6-p so they end up being secr'd out of cell
-> coarse features & restrd joint movement |
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Term
fail to add mann-6-p so they end up being secr'd out of cell
-> coarse features & restrd joint movement |
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Definition
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Term
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Definition
24nm diam, made of a & b tubulin dimers, 13/circum
each dimer binds 2 GTP |
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Term
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Definition
incorporated into flagella, cilia, mitotic spindles
grows slowly, collapses quickly
involved in slow axoplasmic transport in neurons |
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Term
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Definition
microtubule polymerization defect
dn phagocytosis |
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Term
microtubule polymerization defect
dn phagocytosis |
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Definition
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Term
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Definition
9 + 2
dynein:ATPase that links periph doublets & causes bending of colium by differential sliding of doublets |
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Term
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Definition
dynein defect
immotile cilia
URIs
situs inversus |
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
50% chol (stability)
50% phospholipids
sphingolipids, glycolipids, proteins
high chol or long satd fatt acid -> up melting temp
only glycosolyated on interior |
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Term
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Definition
lecithin
major comp of RBC membrane, myelin, bile, surfactant (DPCC)
also used in chol esterification (via LCAT) |
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Term
lecithin
major comp of RBC membrane, myelin, bile, surfactant (DPCC)
also used in chol esterification (via LCAT) |
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Definition
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Term
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Definition
atpase is IC
3na out for 2K in
phos during pump phase |
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Term
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Definition
| inh na/k atpase by binding K+ site |
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
PLC -> PIP2->DAG & IP3
IP3-> up Ca(in)
DAG->PKC |
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Term
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Definition
| up/dn adenylyl cyclase -> up cAMP-> PKA |
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Term
| most abundant protein in body |
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Definition
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Term
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Definition
Bone
tendon, skin, dentin, fascia, cornea, late wound repair
90% of coll |
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Term
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Definition
Cartilage (incl hyaline)
vitr body, nucl pulp |
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Term
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Definition
reticulin:
skin, blood vessels, uterus, fetal tissue, gran tissue |
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Term
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Definition
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Term
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Definition
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Term
Bone
tendon, skin, dentin, fascia, cornea, late wound repair
90% of coll |
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Definition
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Term
Cartilage (incl hyaline)
vitr body, nucl pulp |
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Definition
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Term
reticulin:
skin, blood vessels, uterus, fetal tissue, gran tissue |
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Definition
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Term
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Definition
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Term
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Definition
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Term
| inh na/k atpase by binding K+ site |
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
PLC -> PIP2->DAG & IP3
IP3-> up Ca(in)
DAG->PKC |
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Definition
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Term
| up/dn adenylyl cyclase -> up cAMP-> PKA |
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Definition
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Term
|
Definition
1)a chains = preprocollagen translated in RER
gly-x-y (x & y are pro, OH-pro or OH-lys)2)ER-> hydrox spec pro's & lys w. vit c 3)golgi: glycos pro-a-chain lyses ->procollagen: 3 a chains 4)exocytosis |
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Term
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Definition
5)peptidases cleave terminals -> tropocollagen
6)many staggered tropocollagens reinforced by cov lys-OHlys cross linking (lysyloxidase) to make collagen fibrils |
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Term
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Definition
faulty coll synth->
1. hyperext skin
2.easy bruising
3.hypermobile joints10 types, inh varies
berry aneurysms |
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Term
faulty coll synth->
1. hyperext skin
2.easy bruising
3.hypermobile joints10 types, inh varies
berry aneurysms |
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Definition
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Term
|
Definition
prim AD
var gene defects
abnl collagen synth |
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Term
| osteogenesis imperfecta clin |
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Definition
mult fxs w. min trauma, maybe during birth
blue scerae
hearing loss (abnl inner ear bones)
dental imperfections |
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Term
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Definition
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Term
prim AD
var gene defects
abnl collagen synth |
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Definition
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Term
mult fxs w. min trauma, maybe during birth
blue scerae
hearing loss (abnl inner ear bones)
dental imperfections |
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Definition
| osteogenesis imperfecta clin |
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Definition
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Definition
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Definition
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
Bone
tendon, skin, dentin, fascia, cornea, late wound repair
90% of coll |
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Definition
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Term
Cartilage (incl hyaline)
vitr body, nucl pulp |
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Definition
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|
Term
reticulin:
skin, blood vessels, uterus, fetal tissue, gran tissue |
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Definition
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Definition
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