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trueger
renal phys 1
67
Other
Not Applicable
05/22/2006
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Term
renal aa->
 Definition
segm-> interlobar-> arcuate -> interlobular -> aff -> glom -> eff
Term
renal TB
 Definition
kidney -> bladder
Term
renal schisto
 Definition
bladder -> kidney
Term
macula densa
 Definition
lining of the DCT
sits next to afferent arteriole (JG)
Term
ureter course
 Definition
under uterine aa & under ductus deferens
water (urine) is under the bridge (everything else)
Term
fluid compartments
 Definition
TBW: 60%water
1/3 ECF
1/4plasma & 3/4 interstitial
Term
ICF=
 Definition
TBW-ECF
Term
intersitial vol=
 Definition
ECF - PV
Term
how do u measure plasma volume?
 Definition
radiolabeled albumin measures…
Term
how do u measure ECF?
 Definition
inulin measures…
Term
TBW-ECF
 Definition
ICF=
Term
ECF - PV
 Definition
intersitial vol=
Term
radiolabeled albumin measures…
 Definition
how do u measure plasma volume?
Term
inulin measures…
 Definition
how do u measure ECF?
inulin clearance = GFR
Term
clearance =
 Definition
UV/P
Term
C
 Definition
net tub reabs
Term
C>GFR=
 Definition
net tub excrn
Term
UV/P
 Definition
clearance =
Term
net tub reabs
 Definition
C
Term
net tub excrn
 Definition
C>GFR=
Term
glomeruli filter based on
 Definition
size & net charge (not neg)
Term
when is charge barrier lost?
 Definition
nephrotic syndrome
->massive proteinuria (alb)
Term
what makes up the glom filter?
 Definition
fenestrated caps (size)
fused BM w. hep sulfate (neg charge)
eptih layer of podocyte foot processes
Term
GFR calc'd by
 Definition
inulin clearance=
Term
inulin clearance=
 Definition
GFR calc'd by
Term
effective renal plasma flow (ERPF) estimated by
 Definition
PAH
both filtered & secreted in PT
(all PAH excreted)

ERPF= U(pah)xV/P(Ppah) = C(pah)
Term
RBF=
 Definition
RPF/(1-hct)
Term
ERPF innac
 Definition
underestimates RPF by about 10%
Term
filtration fraction =
 Definition
GFR/RPF
Term
PGs -> RPF
 Definition
dilate aff arteriole -> up RPF, up GFR, FF constant
Term
ATII -> RPF
 Definition
constrict eff arteriole -> dn RPF, up GFR, up FF
Term
aff art constr-> rpf
 Definition
dn RPF, dn GFR, FF cons
Term
eff art constr-> rpf
 Definition
dn RPF, up GFR, FF up
Term
up plasma prot conc -> rpf
 Definition
cons RPF, dn GFR, dn FF
Term
constriction of ureter -> rpf
 Definition
cons RPF, dn GFR, dn FF
Term
free water clearance =
 Definition
V - C(osm)
Term
dilate aff arteriole -> up RPF, up GFR, FF constant
 Definition
PGs -> RPF
Term
constrict eff arteriole -> dn RPF, up GFR, up FF
 Definition
ATII -> RPF
Term
dn RPF, dn GFR, FF cons
 Definition
aff art constr-> rpf
Term
dn RPF, up GFR, FF up
 Definition
eff art constr-> rpf
Term
cons RPF, dn GFR, dn FF
 Definition
up plasma prot conc -> rpf
Term
cons RPF, dn GFR, dn FF
 Definition
constriction of ureter -> rpf
Term
V - C(osm)
 Definition
free water clearance =
Term
glucosuria limits
 Definition
200 = threshold
350 = saturated transporters Tm
Term
amino acid clearance
 Definition
reabs by 3 distinct carriers, each has comp inh
2nd active transport in PT = saturable
Term
early PCT fn
 Definition
R all glu & aa
R most bicarb, Na, water
S ammonia which buffer secr'd H+
Term
early PCT drug
 Definition
acetazolamide
inh CA
Term
acetazolamide
 Definition
early PCT drug
inh CA
Term
R all glu & aa
R most bicarb, Na, water
S ammonia which buffer secr'd H+

 Definition
early PCT fn
Term
thin desc tubule fn
 Definition
passive reabs water via med hyperton
imperm to Na
Term
passive reabs water via med hyperton
imperm to Na
 Definition
thin desc tubule fn
Term
thick asc tubule fn
 Definition
act reabs Na, K, Cl
infirectly induce R of Mg & Ca
imperm to water
Term
act reabs Na, K, Cl
infirectly induce R of Mg & Ca
imperm to water
 Definition
thick asc tubule fn
Term
thick asc tubule drug
 Definition
furosemide
inh Na/K/Cl/Cl trans
Term
furosemide
 Definition
thick asc tubule drug
inh Na/K/Cl/Cl trans
Term
early DCT fn
 Definition
active R NaCl
PTH->R Ca
Term
early DCT drug
 Definition
HCTZ
inh NaCl cotrans
Term
active R NaCl
PTH->R Ca
 Definition
early DCT fn
Term
HCTZ
 Definition
early DCT drug
inh NaCl cotrans
Term
drug inh NaCl cotrans
 Definition
HCTZ
early DCT
Term
drug inh CA
 Definition
acetazolamide
early PCT
Term
drug inh Na/K/ClCl pump
 Definition
furosemide
thick asc loop
Term
CT fn
 Definition
R Na, exch for K or H+
aldo dependent
water R dep on ADH
Term
R Na, exch for K or H+
aldo dependent
water R dep on ADH
 Definition
CT fn
Term
CT drug
 Definition
spironolactone
inh aldo R
Term
spironolactone
 Definition
CT drug
inh aldo R
Term
inh aldo R
 Definition
CT drug
spironolactone
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