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trueger
endo path 1
75
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05/19/2006

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Term
cushings syndrome
Definition
up cortisol
Term
cushings syndrome etios
Definition
dz = prim pit adenoma (up ACTH)
adrenal
ectopic ACTH
iatro (e.g. steroids)
Term
cushings clin
Definition
htn, wt gain, moon facies, truncal obesity, buff hump, hyper gly (insulin res), skin thinning & stria, osteoporosis, amen, dn immun
Term
dex test healthy
Definition
low dose -> dn cortisol
Term
dex test w. ACTH tumo
Definition
low dose -> up cortisol
high dose -> dn cortisol
Term
dex test w. cortisol tumor
Definition
low/high dose -> up cortisol
Term
low dose -> dn cortisol
Definition
dex test healthy
Term
low dose -> up cortisol
high dose -> dn cortisol
Definition
dex test w. ACTH tumo
Term
low/high dose -> up cortisol
Definition
dex test w. cortisol tumor
Term
htn, wt gain, moon facies, truncal obesity, buff hump, hyper gly (insulin res), skin thinning & stria, osteoporosis, amen, dn immun
Definition
cushings clin
Term
primary hyperaldo
Definition
conns
aldo tumor ->htn, hypoK, MB alk, and low renin
Term
secondary hyperaldo
Definition
renal a stenosis, chr RF, CHF, cirrh, or nephrotic syndrome
kidney thinks there's low volume, so up renin
Term
hyperaldo tx
Definition
spironolactone
Term
addison's dz
Definition
primary def in aldo & cortisol due to adr atrophy
-> hypoTN (hypoNa vol contrn) and skin hyper pigm
Term
secondary hyper aldo/cortisol
Definition
no skin hyperpigm
Term
why skin hyperpigm in addisons?
Definition
POMC -> ACTH & MSH
Term
pheo
Definition
chromaffin cells
NF, MEN ii & iii

episodic HTN

Term
neuroblastoma
Definition
anywhere along sympathetic chain
no episodic HTN
Term
pheo secr
Definition
epi, ne, dopamine
Term
pheo labs
Definition
up VMA
up plasma catecholamines
Term
pheo tx
Definition
a antags, exp phenoxybenzamine
Term
pheo sx
Definition
presser
pain (HA)
perspiration (tachycardia)
palpitations
pallor

spells: relapsing/remitting

Term
pheo rule
Definition
10% malign
10%bil
10%extra adr
10% calcify
10% kids
10% familial
Term
chromaffin cells
NF, MEN ii & iii

episodic HTN

Definition
pheo
Term
anywhere along sympathetic chain
no episodic HTN
Definition
neuroblastoma
Term
epi, ne, dopamine
Definition
pheo secr
Term
up VMA
up plasma catecholamines
Definition
pheo labs
Term
a antags, exp phenoxybenzamine
Definition
pheo tx
Term
presser
pain (HA)
perspiration (tachycardia)
palpitations
pallor

spells: relapsing/remitting

Definition
pheo sx
Term
10% malign
10%bil
10%extra adr
10% calcify
10% kids
10% familial
Definition
pheo rule
Term
MEN i
Definition
wermer's syndrome
pancr
parathyroid
pit
Term
men I ssx
Definition
kidney stones & stomach ulcers
Term
men ii
Definition
sipple's
thyroid medullary
pheo
parathyroid
Term
men iii/iib
Definition
thyroid med
pheo
ganglioneuromas
Term
ret oncogene
Definition
men ii & iii
Term
wermer's syndrome
pancr
parathyroid
pit
Definition
MEN i
Term
kidney stones & stomach ulcers
Definition
men I ssx
Term
sipple's
thyroid medullary
pheo
parathyroid
Definition
men ii
Term
thyroid med
pheo
ganglioneuromas
Definition
men iii/iib
Term
men ii & iii
Definition
ret oncogene
Term
men gens
Definition
AD
Term
hypothyroid ssx
Definition
cold intol
hypoact'y
wt gain
fatigue
lethargy
dn appetite
const
wkness
dn reflexes
myxedema (facial/periorbital edema)
dry cool skin
coarse brittle hair
Term
cold intol
hypoact'y
wt gain
fatigue
lethargy
dn appetite
const
wkness
dn reflexes
myxedema (facial/periorbital edema)
dry cool skin
coarse brittle hair
Definition
hypothyroid ssx
Term
hypothyroid labs
Definition
up TSH
dn t4, free t4, t3 uptake
Term
up TSH
dn t4, free t4, t3 uptake
Definition
hypothyroid labs
Term
hyperthyroid ssx
Definition
heat intol, hyperacty, wt loss, chest pain/pals, arrhythmias, D, up reflexes, warm, moist skin & fine hair
Term
hyperthyroid labs
Definition
dn tsh = primary
up t4, free t4, t3 uptake
Term
riedels thyroiditis
Definition
thyr replad by fibr tissue
Term
thyr replad by fibr tissue
Definition
riedels thyroiditis
Term
heat intol, hyperacty, wt loss, chest pain/pals, arrhythmias, D, up reflexes, warm, moist skin & fine hair
Definition
hyperthyroid ssx
Term
dn tsh = primary
up t4, free t4, t3 uptake
Definition
hyperthyroid labs
Term
graves dz
Definition
TSI
type ii hypersens
proptosis, EOM swelling, pretibial myxedema, diffuse goiter
often present during stress
Term
hashimotos thyroiditis
Definition
autoimmune -> hypo thyr
slow course, mod enlarged, nontender thyroid
lymphocytic infitralte w. germinal centers
anti microsomal & anti thyroglobulin Abs
Term
TSI
type ii hypersens
proptosis, EOM swelling, pretibial myxedema, diffuse goiter
often present during stress
Definition
graves dz
Term
autoimmune -> hypo thyr
slow course, mod enlarged, nontender thyroid
lymphocytic infitralte w. germinal centers
anti microsomal & anti thyroglobulin Abs
Definition
hashimotos thyroiditis
Term
subacute thyroiditis
Definition
dequervains
self ltd hypothyr following flu-like illness
up ESR, jaw pain, early inflamm, very tender thyr
can be hyper thyr early
Term
self ltd hypothyr following flu-like illness
up ESR, jaw pain, early inflamm, very tender thyr
can be hyper thyr early
Definition
dequervains
subacute thyroiditis
Term
thyr pap CA
Definition
most common, exc progn, ground glass/orphin annie nucl, psammoma bodis
Term
thyr foll CA
Definition
good progn, uniform follicles w. bits of colloid
Term
thyr med CA
Definition
from parafoll C cells -> calcitonin
sheets of cells in amyloid stroma
men ii & iii
Term
thyr undiff/anaplastic CA
Definition
older pts, poor progn
Term
most common, exc progn, ground glass/orphin annie nucl, psammoma bodis
Definition
thyr pap CA
Term
good progn, uniform follicles w. bits of colloid
Definition
thyr foll CA
Term
from parafoll C cells -> calcitonin
sheets of cells in amyloid stroma
men ii & iii
Definition
thyr med CA
Term
older pts, poor progn
Definition
thyr undiff/anaplastic CA
Term
cretinism
Definition
w. endemic goiter (lack of iodine)
or defect in T4 formn
or def in thyr dev
Term
cretinism ssx
Definition
potbellied, pale, puffy faced kids w. protruding umbilicus & tongue
ment retarded
Term
w. endemic goiter (lack of iodine)
or defect in T4 formn
or def in thyr dev
Definition
cretinism
Term
potbellied, pale, puffy faced kids w. protruding umbilicus & tongue
ment retarded
Definition
cretinism ssx
Term
acromegaly
Definition
excess GH in adults->
lg tongue w. deep furrows
deep voice, lg hands & ft
coarse facial fts, impd glu tol (ins res)
Term
up GH in kids ->
Definition
gigantism
treat w. octreotide
Term
excess GH in adults->
lg tongue w. deep furrows
deep voice, lg hands & ft
coarse facial fts, impd glu tol (ins res)
Definition
acromegaly
Term
gigantism
treat w. octreotide
Definition
up GH in kids ->
Term
nl up GH in…
Definition
stress, exer, hypogly
Term
stress, exer, hypogly
Definition
nl up GH in…
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