Term
|
Definition
nodules <3mm, uniform size
MB insult: etoh, hemechromatosis, wilsons |
|
|
Term
|
Definition
>3mm, varied size
sign liver injury -> hep necr
post inf, drug induced
up risk HCC |
|
|
Term
|
Definition
splenic & left renal v
may relieve portal HTN |
|
|
Term
|
Definition
swollen & necro hepatocytes
PMNs
mallory bodies (intracytoplasmic eo inclusions)
fatty change
sclerosis around central vein
AST>ALT |
|
|
Term
|
Definition
occlusion of IVC or hep veins w. centrilobular congestion & necrosis
->congestive liver dz
(HM, ascites, abd pain, eventual LF)assoc'd w. polycyth vera, preg & HCC |
|
|
Term
occlusion of IVC or hep veins w. centrilobular congestion & necrosis
->congestive liver dz
(HM, ascites, abd pain, eventual LF)assoc'd w. polycyth vera, preg & HCC |
|
Definition
|
|
Term
|
Definition
inadeq hep copper excr'n & failure of copper to enter circ as ceruloplasmin
->copper accum, esp in liver, brain, joints, cornea, kidney
aka "hepatolenticular degen" |
|
|
Term
|
Definition
Asterixis
Basal ganglia degen (parkinsonian)
Ceruloplasmin dn, Cirrh, Corneal deposits (keyser fleischer), CA (HCC), Chorea
Dementiatx:penicillamince
gen: AR |
|
|
Term
|
Definition
deposition of hemosiderin (iron) = hemosiderosis
dz caused by this = hemechromatosis
micronodular cirrh, pancr fibr, skin pigm ->bronze diabetes
results in CHF & up risk HCC
prim: AR; or 2nd to chr transfusion tx
up ferritn, up iron, dn TIBC-> up transferrin sat
tx:rep'd phlebotomy, deferoxamine |
|
|
Term
|
Definition
| conj & unconj, up UBR, nl or dn urine urobilinogen |
|
|
Term
|
Definition
| conj, up UBR, dn urine urobilinogen |
|
|
Term
|
Definition
| unconj, absent UBR, up urine urobilinogen |
|
|
Term
| conj & unconj, up UBR, nl or dn urine urobilinogen |
|
Definition
|
|
Term
| conj, up UBR, dn urine urobilinogen |
|
Definition
|
|
Term
| unconj, absent UBR, up urine urobilinogen |
|
Definition
|
|
Term
|
Definition
liver: unconj->conj-> urine & bile
some: gut bac -> urobilinogen (some reabs)
some heme -> directly to urobilinogen |
|
|
Term
|
Definition
gilberts
crigler-najjar type i
dubin-johnson |
|
|
Term
|
Definition
mild dn UDP-glucuronyl transferase
asx
up unconj BR w/o hemolysis
assoc'd w. stress
no clin consequnces |
|
|
Term
|
Definition
absent UDP-glucuronyl transferase
presents early in life
die w.in few yrs
ssx: jaundice, kernicterus, up unconj BR |
|
|
Term
|
Definition
| less severe, responds to phenobarbital |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
conj hyperBR due to defective liver excr'n
grossly black liver
benign |
|
|
Term
|
Definition
| mild dubin-johnson, w.o black liver |
|
|
Term
mild dn UDP-glucuronyl transferase
asx
up unconj BR w/o hemolysis
assoc'd w. stress
no clin consequnces |
|
Definition
|
|
Term
absent UDP-glucuronyl transferase
presents early in life
die w.in few yrs
ssx: jaundice, kernicterus, up unconj BR |
|
Definition
|
|
Term
| less severe, responds to phenobarbital |
|
Definition
|
|
Term
conj hyperBR due to defective liver excr'n
grossly black liver
benign |
|
Definition
|
|
Term
| mild dubin-johnson, w.o black liver |
|
Definition
|
|
Term
|
Definition
intra & extra hep
infl & fibr of bile ducts-> alt strictures & dil'n = beading on ERCP
ass'd w/ UCcharcot's triad: jaundice, fever, RUQ pain
can lead to 2nd bil cirrh |
|
|
Term
|
Definition
|
|
Term
|
Definition
intrahepatic autoimmune
severe obstr jaundice
steatorrhea, pruritis, hyperchol, up alk phos, up serum mt Abs |
|
|
Term
|
Definition
extrahep bil obstrn
up pressure in hep ducts -> inj & fibr
often compl'd by cholangitis (bac infn), bile stasis, bile lakes
up alk phos, up conj BR |
|
|
Term
|
Definition
most common prim hep CA (mets= more)
assocd w/ HBV, HCV, wilsons, hemechrom, a1antitrypsin def, alc cirrh, carcinogens (aflatoxin b1)
ssx: tender HM, ascites, polycyth, hypoglycemia, a-fetoprotein
hem spread, budd chiari |
|
|
Term
|
Definition
HBV
HCV
wilsons
hemechrom
a1antitrypsin def
alc cirrh
carcinogens (aflatoxin b1) |
|
|
Term
|
Definition
rare, fatal childhood hepatoencephalopathy
ssx: fatty liver (microvesicular), hypogly, coma
assoc w. viral infn (esp VZV & flu b) and salicylates
use acetaminophen for ped F |
|
|
Term
| microvesicular fatty liver |
|
Definition
| reye's, preggers, and tetracycline & valproic tox |
|
|
Term
|
Definition
| up chol and/or BR > solub. Bile acids & lecithins |
|
|
Term
|
Definition
radiolucent
obesity, crohns, CF, age, clofinrate, estrogens, multiparity, rapid wt loss, Nams |
|
|
Term
|
Definition
radiolucent
chol & BR
most common |
|
|
Term
|
Definition
radioopaque
chronic RBC hemolysis, alcoholic cirrh, adv'd age, biliary infn |
|
|
Term
radiolucent
obesity, crohns, CF, age, clofinrate, estrogens, multiparity, rapid wt loss, Nams |
|
Definition
|
|
Term
radiolucent
chol & BR
most common |
|
Definition
|
|
Term
radioopaque
chronic RBC hemolysis, alcoholic cirrh, adv'd age, biliary infn |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| actn pancr enzymes -> autodigestion |
|
|
Term
|
Definition
Gallstones
Etoh
Trauma
Steroids
Mumps
Autoimmune dz
Scorpion sting
HyperCa/lips
Drugs (sulfa) |
|
|
Term
|
Definition
epiG abd pain lancinate to back
anorexia
N |
|
|
Term
|
Definition
| DIC, ARDS, diffuse fat necr, hypoCa, pseudocyst, hem, infn |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
6 mos progn
aggr
us met'd by pres
pancr head (obstr jaundice) |
|
|
Term
|
Definition
abd pain rad to back
wt loss (malabs)migr thrombophlebitis (trousseaus syndrome)
obstr jaudice w. palp GB (courvoisier's sign) |
|
|
Term
|
Definition
obstr jaundice w. palp GB
pancr adCA |
|
|
Term
|
Definition
trousseau's sign
pancr adCA |
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