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trueger
blood cancers
127
Medical
Graduate
04/30/2006
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Term
t(9:22)
 Definition
bcr-abl (Ph) (CML, ALL, AML)
Term
t(4:11)
 Definition
AF4/MLL (ALL <2yo, AML)
Term
t(8:14)
 Definition
Myc/Ig (Burkitt's, ALL)
Term
t(12:21)
 Definition
tel/AML1 (ALL)
Term
TdT+, CD10+, T:CD1-8, BCd19,20,22
 Definition
ALL cell markers
Term
blasts, 2-4 & 60, chemo resp, testes/CNS, >50 pleudy, -> lymph (m/s)
 Definition
ALL chars
Term
t(8:21)
 Definition
AML1/ETO (AML)
Term
t(15:17)
 Definition
PML/RARa (AML: M3)
Term
inv(16)
 Definition
CaFB/MYH11 (AML)
Term
t(11q23:v)
 Definition
MLL (AML: poor progn)
Term
CD13,33
 Definition
AML myeloid cell markers (EPO)
Term
CD14
 Definition
AML mono cell markers (but. est.)
Term
CD41,61
 Definition
AML megaK cell markers
Term
chem unresp, inh term diff'n, bleeding (DIC), skin/gingiva, adults
 Definition
AML chars
Term
del 11q
 Definition
CLL geno
Term
trisomy 12
 Definition
CLL geno
Term
del 13q
 Definition
CLL geno
Term
del 17p (p53)
 Definition
CLL geno (poor progn)
Term
B: CD20,5,23
 Definition
CLL markers
Term
hypogammaglobulinemia, transform-> PLL/Richter(DLCL),hem anem, >50yo,smudge cells
 Definition
CLL chars
Term
t(9:22)
 Definition
bcr-abl up TK (CML)
Term
cellular BM,up megaKs,no fibr,lt shft,stable w/tx but>blast(AML-like),older,tx:BM trans,IFNa,gleevac
 Definition
CML chars
Term
del/rear 13q
 Definition
MM geno
Term
t(4:14)(p16.3:q32)
 Definition
MM geno (up FGFR3)
Term
up FGFR3, cyclin D1, D3
 Definition
MM pheno
Term
lytic bone, osteopor, BJ->ren insuf, BM plasmacytosis, upCa++, dn hum imm, 50-60
 Definition
MM chars
Term
osseus->MM, fac spaces-> good progn
 Definition
solitary myeloma
Term
t(14:18)
 Definition
bcl-2 (Foll Lymphoma)
Term
CD19,20,10
 Definition
foll lymp markers
Term
I: sm cleaved, III: Lg, up nucleoli
 Definition
foll classes
Term
GCB cells, adults, 45%NHL, trans->DLCL
 Definition
foll chars
Term
t(3q27:v)
 Definition
bcl-6 (or prom)(DLCL geno)
Term
CD20+ TdT-
 Definition
DLCL markers
Term
30%NHL, sx,tx,GCBvsnon,60yo
 Definition
DLCL chars
Term
immunosuppr-> no T's = EBV;primary effusion: HIV->HHV8
 Definition
DLCL subtypes
Term
AIDS/EBV+, histiocytes w/clr space= starry sky, effaced LN, Afr:mandible (vs abd), kids/ygadults
 Definition
Burkitt's chars
Term
k/l(t(2:8)
 Definition
Burkitt's geno
Term
BM,B->IgM,cryo,visc,CNS,vis,LAD,HSM,hemanem& Bmanem, Dutcher&Russell,tx
 Definition
Waldenstrom's Macroglobulinemia/Lymphoplasmacytic Lymphoma
Term
Russell Bodies
 Definition
cyt plasm incl (Waldenstrom)
Term
Dutcher Bodies
 Definition
nucl incl (Waldenstrom)
Term
t(11:14)
 Definition
bcl1,cyclinD1(mantle cell lymphoma)
Term
smB w/ irreg membr
 Definition
mantle cell histo
Term
LAD,BM(PB:1/3), lymphoid int'l polypoids, w/p53->poor progn
 Definition
mantle cell chars
Term
t(11:18)
 Definition
marg zone lymphoma geno
Term
t(1:14)
 Definition
marg zone lymphoma geno
Term
H pylori
 Definition
MALToma etio
Term
w/autoimmune (hashimotos/sjogrens)
 Definition
marginal zone/MALToma chars
Term
B w/ cytoplasmic arms
 Definition
hairy cell histo
Term
middleaged male w/ pancytopenia, redpulp->SM, BM, TRAP
 Definition
hairy cell chars
Term
CD25+
 Definition
hairy cell marker
Term
CD25
 Definition
IL-2R
Term
TRAP
 Definition
test for Hairy cell
Term
NKs/Ts, CD3+2-5-7-,up vasc, 15%NHL, asia, LAD, eo, pruritis, F, wt loss
 Definition
PTCL chars, incl markers
Term
anaplastic, mycosis fungoides, Lg gran cell lymphocytic, extranodal NK/T
 Definition
PTCL types
Term
t(2:5)
 Definition
NPM-ALK (anaplastic Lg cell lymphoma)
Term
Lg atyps, good progn, NPM-ALK
 Definition
anaplastic Lg cell lymphoma chars
Term
HTLV-1,Sjap,Wafr,Carib, Skin,HSM,lymphos,upCa++
 Definition
Adult Tcell Lymphoma chars
Term
floret cells (CD4+), PB lymphos
 Definition
Adult Tcell Lymphoma histo
Term
skin,epidermitropism
 Definition
mycosis fungoides clin
Term
infl->plaque->tumor
 Definition
mycosis fungoides stages
Term
MF w/ PB lymphos
 Definition
sezary syndrome
Term
T/NK->PB, abund cytoplasm w/ azur granules
 Definition
Lg granular lymphocytic leukemia histo
Term
dn PMNs, anemia (+/- RBC aplasia)
 Definition
Lg granular lymphocytic leukemia chars
Term
"midline granuloma", infil sm vessels->necr, EBV+, aggr
 Definition
extranodal NK/T lymphoma chars
Term
bcr-abl (Ph) geno/CA
 Definition
t(9:22) CML, ALL, AML
Term
AF4/MLL geno/CA
 Definition
t(4:11) ALL <2yo dn progn, AML
Term
Myc/Ig geno/CA
 Definition
t(8:14) ALL, Burkitts
Term
tel/AML1 geno/CA
 Definition
t(12:21) ALL
Term
ALL genos
 Definition
t(9:22):Ph bcr-abl (cml,aml); (4:11):AF4/MLL(<2/y0)(AML); t(8:14):myc/Ig(burkitts); t(12:21)tel/AML1
Term
ALL cell markers
 Definition
TdT+, CD10+, T:CD1-8, BCd19,20,22
Term
ALL chars
 Definition
blasts, 2-4 & 60, chemo resp, testes/CNS, >50 pleudy, -> lymph (m/s)
Term
AML1/ETO geno/CA
 Definition
t(8:21) AML
Term
PML/RARa geno/CA
 Definition
t(15:17) AML: M3, DIC
Term
CaFB/MYH11 geno/CA
 Definition
inv(16) AML
Term
MLL geno/CA
 Definition
t(11q23:v) AML poor progn
Term
AML genos
 Definition
t(8:21)AML1/ETO;t(15:17)PML/RARa;inv(16)CafB/MYH11;t(11q23:v)MLL
Term
AML myeloid cell markers (EPO)
 Definition
CD13,33
Term
AML mono cell markers (but. est.)
 Definition
CD14
Term
AML megaK cell markers
 Definition
CD41,61
Term
AML markers
 Definition
CD13,33(myeloid,EPO,Auer) CD14(mono) Hb(eythroid) CD41,61(megaK)
Term
AML chars
 Definition
chem unresp, inh term diff'n, bleeding (DIC), skin/gingiva, adults
Term
CLL geno
 Definition
del 11q,tri12,del 13q, del 17p (p53)
Term
CLL markers
 Definition
B: CD20,5,23
Term
CLL chars
 Definition
hypogammaglobulinemia, transform-> PLL/Richter(DLCL),hem anem, >50yo, smudge cells
Term
bcr-abl geno/CA/pheno
 Definition
t(9:22), CML, up TK
Term
CML chars
 Definition
cellular BM,up megaKs,no fibr,lt shft,stable w/tx but>blast(AML-like),older,tx:BM trans,IFNa,gleevac
Term
MM geno
 Definition
del/rear 13q, t(4:14)(p16.3:q32) FGFR3 cyclin D1,3
Term
MM pheno
 Definition
up FGFR3, cyclin D1, D3
Term
MM chars
 Definition
lytic bone, osteopor, BJ->ren insuf, BM plasmacytosis, upCa++, dn hum imm, 50-60
Term
solitary myeloma
 Definition
osseus->MM, fac spaces-> good progn
Term
bcl-2 geno/CA
 Definition
t(14:18) (Foll Lymphoma)
Term
foll lymp markers
 Definition
CD19,20,10
Term
foll classes
 Definition
I: sm cleaved, III: Lg, up nucleoli
Term
foll chars
 Definition
GCB cells, adults, 45%NHL, trans->DLCL
Term
bcl-6 geno/CA
 Definition
t(3q27:v) DLCL, or prom (up progn)
Term
DLCL markers
 Definition
CD20+ TdT-
Term
DLCL chars
 Definition
30%NHL, sx,tx,GCBvsnon,60yo
Term
DLCL subtypes
 Definition
immunosuppr-> no T's = EBV;primary effusion: HIV->HHV8
Term
Burkitt's chars
 Definition
AIDS/EBV+, histiocytes w/clr space= starry sky, effaced LN, Afr:mandible (vs abd), kids/ygadults
Term
Burkitt's geno
 Definition
k/l(t(2:8), t(8:14) (Myc/Ig)
Term
Waldenstrom's Macroglobulinemia/ Lymphoplasmacytic Lymphoma
 Definition
BM,B->IgM,cryo,visc,CNS,vis,LAD,HSM,hemanem &Bmanem,Dutcher&Russell,tx
Term
cytoplasm incl
 Definition
Russell Bodies (Waldenstrom)
Term
nucl incl
 Definition
Dutcher Bodies (Waldenstrom)
Term
bcl1,cyclinD1 geno/CA
 Definition
t(11:14) (mantle cell lymphoma)
Term
mantle cell histo
 Definition
smB w/ irreg membr
Term
mantle cell chars
 Definition
LAD,BM(PB:1/3), lymphoid int'l polypoids, w/p53->poor progn
Term
marginal zone lymphoma geno
 Definition
t(11:18), t(1:14)
Term
MALToma etio
 Definition
H pylori
Term
marg zone/MALToma chars
 Definition
w/autoimmune (hashimotos/sjogrens)
Term
hairy cell histo
 Definition
B w/ cytoplasmic arms
Term
hairy cell chars
 Definition
middleaged male w/ pancytopenia, redpulp->SM, BM, TRAP
Term
hairy cell marker
 Definition
CD25+
Term
IL-2R
 Definition
CD25
Term
test for Hairy cell
 Definition
TRAP
Term
PTCL chars incl markers
 Definition
NKs/Ts, CD3+2-5-7-,up vasc, 15%NHL, asia, LAD, eo, pruritis, F, wt loss
Term
PTCL types
 Definition
anaplastic, mycosis fungoides, Lg gran cell lymphocytic, extranodal NK/T
Term
NPM-ALK geno/CA
 Definition
t(2:5) (anaplastic Lg cell lymphoma)
Term
anaplastic Lg cell lymphoma chars
 Definition
Lg atyps, good progn, NPM-ALK
Term
Adult Tcell Lymphoma chars
 Definition
HTLV-1,Sjap,Wafr,Carib, Skin,HSM,lymphos,upCa++
Term
Adult Tcell Lymphoma histo
 Definition
floret cells (CD4+), PB lymphos
Term
mycosis fungoides clin
 Definition
skin,epidermitropism
Term
mycosis fungoides stages
 Definition
infl->plaque->tumor
Term
sezary syndrome
 Definition
MF w/ PB lymphos
Term
Lg granular lymphocytic leukemia histo
 Definition
T/NK->PB, abund cytoplasm w/ azur granules
Term
Lg granular lymphocytic leukemia chars
 Definition
dn PMNs, anemia (+/- RBC aplasia)
Term
extranodal NK/T lymphoma chars
 Definition
"midline granuloma", infil sm vessels->necr, EBV+, aggr
Term
smudge cells
 Definition
CLL/SLL
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