Term
| Graft rejection mediated by adaptive immune system |
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Definition
Shows specificity and memory
Dependent upon lymphocytes |
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Term
| Barriers to Tissue Transplantation |
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Definition
MHC's
Minor histocompatibility Antigens
- When MHC class I molecules scavenge for antigens inside cells, peptides of donor/recipient do not match
- Polymorphism of histocompatibility molecules is barrier to transplantation |
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Term
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Definition
| Cell or tissue present in some members of a species, but not others |
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Term
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Definition
| T cells or antibodies from one individual that will react with tissue antigens of second genetically different individual |
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Term
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Definition
| Graft transplanted from one individual to the same individual |
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Term
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Definition
| Graft transplanted from one individual to a second genetically different individual of the same species |
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Term
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Definition
| graft transplanted from one individual to a second genetically identical individual |
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Term
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Definition
| Graft from one species to another |
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Term
| Direct Alloantigen Recognition |
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Definition
| T cells bind directly to intact allogeneic MHC molecule on a donor antigen-presenting cell |
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Term
| Indirect ALloantigen Recogntion |
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Definition
Allogeneic MHC molecules from graft cells take n up and processed by recipient APCs
Peptide fragments of allogeneic MHC molecules bound and presented by recipient MHC molecules |
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Term
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Definition
| Alloantibodies and complement cause endothelial damage, inflammation and thrombosis |
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Term
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Definition
Alloreactive recipient T cells attack graft causing parychemal damage and inflammation
- due to direct alloantigen recognition by recipient T cells |
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Term
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Definition
Induces graft arteriosclerosis and vessel occlusion
- due to direct and indirect alloantigen recognition by recipient T cells |
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Term
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Definition
Cyclosporine & Tacrolimus
- Most usefful class of immunosuppressive drugs
- Calcineurin inhibitors
* block calcineurin (T cell phosphatase)
* Inhibits transcription of cytokine genes in T cells |
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Term
| Sources of Hematopoietic Stem Cells |
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Definition
Bone marrow
Peripheral blood
Placental cord blood
Fetal liver |
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Term
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Definition
Major problem
- Immune system destroyed by radiation and chemicals prior to transplant
- GVH occurs when donor T cells react against tissue antigens of recipient
- Life threatening situation |
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