1. M protein (cellular antigen) - Major virulence factor 
2. Protein G (cellular antigen) - anti phagocytic
3. Capsule (cellular antigen) - anti phagocytic
4. Streptolysin O (cytolytic toxin; anti RBCs and phagocytes)
5. Streptolysin S (cytolytic toxin; anti RBCs and phagocytes)
6. SpeA, SpeC (superantigens, inflammatory) - Pyrogenic; Activates T-cells
7. Exo-enzynes

1. Capsule (Major virulence factor)

2. Pneumolysin (cross reacts with Streptolysin O; kills phagocytes)

3. Exotoxins

(4. IgA protease) 

1. Protein A (cellular antigen; binds Fc of immunoglobulin so antiphagocytic)

2. Capsule

3. α toxin (cytolytic exotoxn kills phagocytes)

4. enterotoxin (food poisoning)

5. toxic shock syndrome toxin 1 (superantigen)

6. exfoliative toxin (scalded skin syndrome)

7. exoenzymes

1. cord factor

2. PPD

1. Capsule (major virulence factor; b=bad)

2. LPS

3. Exoenzymes

(4. IgA proteases)

(5. B-lactamase)

1. Pertussis toxin - increased intracellular cAMP (neutrophil inhibition)

2. Tracheal cytotoxin - inhibits cilliated cells; inflammatory

3. Adenylate cyclase (adds baterial cAMP) - neutrophil inhibition

(4. dermatonecrotic toxin)