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Toxicology
toxicology
14
Chemistry
Undergraduate 4
02/25/2010

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Cards

Term
Physiologic effects of drug metabolism
Definition
Absorption, distribution, metabolism, excretion
Term
Methanol metabolites
Definition
Formaldehyde to formic acid
Term
Ethanol metabolites
Definition
Acetaldehyde, acetic acid
Term
Cocaine metabolites
Definition
Benzoylecgonine, Ecgonine methyl ester
Term
Heroin metabolites
Definition
6-monoacetylmorphine
Term
Reverse phase HPLC
Definition
non polar stationary phase and polar mobile phase
Term
Digoxin
Definition
Heart failure
Term
Phenytoin
Definition
seizures, epilepsy
Term
Lithium
Definition
Depression, bipolar disorder
Term
Theophylline
Definition
Asthma and pulmonary disease
Term
Absorption
Definition
Drug crosses cell membranes of GI tract and enters blood
Term
Distribution
Definition
Drug enters blood and reaches equilibrium btwn body fluid compartments. Free drug reaches site of action
Term
Metabolism
Definition
Takes place mostly in liver. Drugs detoxified by oxidation, reduction, hydrolysis or addition of chemical groups mainly glucuronides and sulfates. Each successive pass through the liver makes drug more water soluble
Term
Excretion
Definition
Urinary excretion major elimination pathway of drug and metabolites
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