EDROPHONIUM

(Tensilon)

PHYSOSTIGMINE

(Eserine)

DONEPEZIL

(Aricept)

PRALIDOXIME

(Photopam, 2-PAM)

• Type: Reactivates cholinesterase that has been inhibited • Receptor: NA

• Indications: Anticholesterase OD, Organophosphate poisoning, nerve gas poisoning

• Contraindications: Allergies

• Drug-Drug:

• Route: IM, IV

• Side FX: ↑ creatine kinase, cardiac arrest, seizure, apnea, laryngeal spasm

TROPICAMIDE

(Mydriacyl)

IPRATROPIUM

(Atrovert)

BETHANECHOL

(Urecholine)

• Type: Cholinergic Agonist
• Use: Stimulate bladder and GI muscles
• Receptor: Selectively muscarinic receptor
• Indications: Post-op/Postpart to ↑ bladder muscle tone w/ nonobstructive neurogenic urinary retention. After childbirth or surgery after anesthetics
• Contraindications: Asthma, HTN, compromised GI/Bladder wall, CAD, epilepsy, Hyperthyroidism, Parkinson's, peptic ulcers
• Drug-Drug: 
• Route: PO, SC
• Side FX: DUMBELSS

ACETYLCHOLINE

• Type: Cholinergic Agonist
• Receptor: ALL cholinergic sites
• Indications: * Used to Miosis during ophthalmic surgery, coronary angiography, Know Ach ANS effects

• Skeletal muscle-Contraction, 
• Ganglion-Stimulation, 
• CNS-Neurotransmissio

• Contraindications: Allergy
• Route: Eye drops
• Side FX: DUMBELSS

PILOCARPINE

(Salagen)

• Type: Cholinergic Agonist 
• Receptor: Muscarinic (ALL)
• Indications: Radiation induced xerostomia, ↓ intraocular pressure, Sjögren's syndrome
• Contraindications: When miosis is undesirable, pupillary block glaucoma, uncontrolled asthma
• Drug-Drug: NA
• Route: eye drops, tablets
• Side FX: DUMBBELSS

VARENICLINE

(Chantix)

• Type: Cholinergic Agonist
• Receptor: Neuronal nicotinic (N_n)
• Indications: Smoking cessation
• Contraindications: Allergies
• Drug-Drug: 
• Route: PO
• Side FX: DUMBBELSS

• Type: Cholinergic Agonist
• Receptor: Muscarinic (ALL)
• Indications: 
• Contraindications: Allergies
• Drug-Drug: 
• Route: PO
• Side FX: DUMBBELSS

• Type: Cholinergic Agonist
• Receptor: Nicotinic (ALL)
• Indications: Smoking cessation
• Contraindications: Allergies
• Drug-Drug: 
• Route: PO, Gum, transdermal patch
• Side FX: DUMBBELSS

NEOSTIGMINE

(Prostigmine)

• Type: Cholinesterase Inhibitor
• Receptor: NA
• Indications:MG (Myasthenia gravis), Use to↑GI & bladder motility
• Contraindications: mechanical intestinal tract obstruction, peritenitis, mech. urinary tract obstruction
• Drug-Drug: Succinylcholine
• Route: oral
• Side FX: bradycardia, excessive salivation muscle fasciculation, AV block, Bradyarryhthmia, cardiac arrest, dysrryhtmias, anaphylaxis LOC, seizures

• Type: Muscarinic Antagonist
• Receptor: Muscarinic M3
• Indications: For urinary urgency, cysitis, overacting GI
• Contraindications: Urinary retention
• Drug-Drug: Donepezil
• Route: PO
• Side FX: Angioedema

• Type: Nicotinic Antagonist (Depolarizing neuromuscular blocking agent
• Receptor: Nicotinic M
• Indications: Use for muscle relaxation during surgery
• Contraindications: If bloodwork indicates high [K+], risk of hyperkalemia→cardiac arrest, not for 3° burn victims, children
• Drug-Drug: 
• Route: 
• Side FX: post-op myalgia

MOA: causes persistent depolarization of end motor plate > fasisculation > fatigue  relaxation

• Type: Direct-acting Beta Agonist
• Receptor:  β1>β2
• Indications: acute heart failure, Used for heart stimulation during heart surgery
• Contraindications: 
• Drug-Drug: 
• Route: parenteral
• Side FX: 

• Type: Direct-acting Beta agonist
• Receptor: ALL
• Indications: Rx or hemostatis, adjunct to local anesthetics, Rx for acute asthma, DOC anaphylaxis, cardiac arrest, hypotension
• Contraindications: 
• Drug-Drug: 
• Route: aerosol, parenteral, opthalmic
• Side FX: vasoconstriction (a1), ↑BP (a1), bronchodilation (b2)

• Type: Direct-acting beta agonist
• Receptor: β2
• Indications: Acute asthma
• Contraindications: 
• Drug-Drug: 
• Route: PO, inhalant
• Side FX: Possible tremors

• Type: Direct-acting Adrenoreceptor Agonist
• Receptor: α1 agonist
• Indications: Rx for nasal congestion, Used to elicit mydriasis, Tx of shock, hypotension, maintenance of BP
• Contraindications: 
• Drug-Drug: 
• Route: PO, parenteral, nasal, ophthalmic
• Side FX: angioedema

AMPHETAMINE

(Ritalin)

• Type: Indirect-acting Adrenoreceptor Agonist
• Receptor: SANS (sk. muscle B.V.), CNS, NE releaser
• Indications: Rx for ADHD, narcolepsy
• Contraindications: 
• Drug-Drug: 
• Route: PO
• Side FX: vasoconstriction, ↑ CNS stimulation

• Type: Indirect-acting adrenoreceptor agonist
• Receptor: NA, NE reuptake blocker
• Indications: Used for topical vasoconstriction, local anesthetic
• Contraindications: 
• Drug-Drug: 
• Route: Inhalation
• Side FX: vasoconstriction, cardiac stimulation, ↑BP, ischemia & necrosis of nasal mucosa

• Type: Indirect-acting  adrenoceptor agonist
• Receptor: Mixed sympathomimetic (NE release, Binds to NE receptor)

• Indications: congestion, Rx for cold symptoms
• Contraindications: 
• Drug-Drug: 
• Route: PO, PE
• Side FX: tachycardia, ↑ BP, urinary retention, insomnia, do NOT use on children <6yo

PSEUDOEPHEDRINE

(Sudafed)

• Type: Indrect-acting adrenoceptor agonist
• Receptor: NA, NE releaser
• Indications: Tx for nasal congestion, allergic rhinitis
• Contraindications: 
• Drug-Drug: 
• Route: PO
• Side FX: tachycardia, ↑ BP, urinary retention, insomnia, do NOT use on children <6yo

PHENTOLAMINE

(Regitine)

• Type: Alpha Adrenoceptor Antagonist
• Receptor: α1 ,α2
• Indications: Severe HTN (eg. Pheochromocytoma--catecholamine secreting tumor)
• Contraindications: 
• Drug-Drug: 
• Route: PE
• Side FX: Vasodilation, tachycardia, ↓BP, dizziness

PRAZOSIN

(Minipress)

• Type: Alpha adrenoceptor antagonidt
• Receptor: α1 blocker
• Indications: Rx for HTN, benign prostatic hyperplasia
• Contraindications: 
• Drug-Drug: 
• Route: PO
• Side FX: vasodilation. ↓BP, relax bladder
• MOA: comp a1 blocker

DOXAZOSIN

(Cardura)

PROPRANOL

(Inderal)

• Type: Beta Adrenoceptor Antagonist
• Receptor: β1, β2 (NON-SELECTIVE) MSA
• Indications: Rx for glaucoma HTN, angina pectoralis, cardiac arr, Performance anxiety, ↓HR, 
• Contraindications: Asthma (due to bronchospasm), vasospasm, hyperlipidemias, vascular disease
• Drug-Drug: 
• Route: PO
• Side FX: bronchospasm, vasospasm, sedative

ATENOLOL

(Tenormin)

 Type: Beta Adrenoceptor Antagonist
• Receptor: β1 blocker (selective)
• Indications: Rx for High HR, HTN, angina pectoris, acute MI
• Contraindications: 
• Drug-Drug: 
• Route: PO, IV
• Side FX: ↓BP, ↓HR

METOPROLOL

(Lopressor)

• Type:  Beta Adrenoceptor Antagonist
• Receptor: β1 blocker (selective)
• Indications: Rx for HTN, Cardiac arr
• Contraindications: 
• Drug-Drug: 
• Route: PO, Parenteral
• Side FX: ↓BP

*MSA

• Type: Beta Adrenoceptor Antagonist
• Receptor:  β1 blocker (selective)
• Indications: Rx for High HR, High BP
• Contraindications: 
• Drug-Drug: 
• Route: 
• Side FX: ↓BP

*ISA (intrinsic sympathomimetic activity)

*MSA

Carvedilol

(Coreg)

• Type: Beta AND Alpha blocker
• Receptor: α & β
• Indications: Heart failure, HTN - causes vasodilation and ↓HR↓BP
• Contraindications: 
• Drug-Drug: 
• Route: 
• Side FX: Vasodilation, BUT ↑CO (by ↓afterload which is great for pt's with health failure)

Labetolol

(Trandate)

• Type:  Beta AND Alpha blocker
• Receptor: α1 & β1 β2 blocker
• Indications:  HTN - causes vasodilation and ↓HR↓BP, Rx for heart failure
• Contraindications: 
• Drug-Drug: 
• Route: 
• Side FX: Vasodilation

*MSA