Term
| Classic findings in congenital toxoplasmosis |
|
Definition
| Hydrocephalus, chorioretinitis, intracranial periventricularl calcifications |
|
|
Term
| In congenital toxoplasmosis, affected infants tend to be... |
|
Definition
| Small for gestational age, jaundiced, hepatosplenomegaly, generalized macula papular rash, seizures. |
|
|
Term
| How to diagnose congenital toxoplasmosis? |
|
Definition
| IgG specific antibodies, which achieve peak concentration 1-2 months after infection, also IgM. |
|
|
Term
| What is the required work up for an infant wit 4- fold increase in igG titers for toxoplasmosis? |
|
Definition
| Thorough ophthalmologic, auditory, and neurological evaluation, including head CT, CSF analysis. |
|
|
Term
| When is the high risk exposure for toxoplasmosis during pregnancy? |
|
Definition
|
|
Term
| What medication would you use to treat symptomatic congenital toxoplasmosis? Asymptomatic? For how long should you treat? |
|
Definition
| Pyrimethamine supplemented with folic acid in combination with sulfadiazine. Duration of therapy is prolonged, even up to on year. |
|
|
Term
| At what point during pregnancy is infection with Rubella the most likely to result in congenital defects? |
|
Definition
| The first four weeks. There is an 80% risk of congenital defects if infection is acquired during this time. If infection is acquired in weeks 13-16, there is only 30% chance, after that, virtually no risk. |
|
|
Term
| What are the most common characteristic abnormalities associated with congenital rubella? |
|
Definition
| Ophthalmologic abnormalities: cataracts, retinopathy, and glaucoma. Cardiac abnormalities including ductus arteriosus and peripheral pulmonary artery stenosis, sensorineural hearing loss, |
|
|
