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Thyroid- or Adrenal-Associated Dysfunction Drugs
PHAR450
10
Pharmacology
Undergraduate 4
04/01/2014

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Cards

Term
Sodium levothyroxine (Synthroid-T4)
Definition
Hormone replacement therapy for hypothyroidism
Term
Sodium liothyronine (Cytomel-T3)
Definition
Hormone replacement therapy for hypothyroidism
4 times as potent as T4, more rapid onset of action, same efficacy
Term
Propylthiouracil
Definition
Used in the treatment of hyperthyroidism
Inhibits peroxidase enzyme system responsible for synthesis of T4 and T3
Inhibits conversion of T4 to T3
Term
Radioactive iodide
Definition
Releases gamma rays & ablates 80-90% of the thyroid, surgical removal of any remnants
Gamma rays are localized in the thyroid only
Term
Prednisone
Definition
Corticosteroid, immunosuppresant
Overuse may result Cushing syndrome
Term
Dexamethasone
Definition
Treatment for Conn's syndrome
Suppresses ACTH release from the pituitary
Term
Hydrocortisone
Definition
Cortisol in oral, intravenous or topical forms
Prescribed for use in several situations
Used as cortisol replacement in the event of surgery to remove pituitary or adrenal tumour
Term
Fludrocortisone
Definition
Synthetic cortisteroid
Mineralcorticoid > glucocorticoid
Used as aldosterone replacement in adrenal insufficiency and adrenal hyperplasia
First line treatment for orthostatic intolerance and Postural Tachycardia Syndrome
Term
Spiralactone
Definition
Competitive antagonist of the mineralcorticoid receptor
Used mainly as a potassium sparing diuretic & antihypertensive
Also reduced elevated or unwanted androgen activity
Term
Eplerenone
Definition
Competitive antagonist of the mineralcorticoid receptor
More selective than spirolactone (no androgen effects)
Marketed for the reduction of cardiovascualr risk in patients following myocardial infarction
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