Term
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Definition
Class: thyroid drug
Mechanism: agonist at thryoid receptors
Indications: hypothyroidism, pituitary TSH surpression
Contraindications: acute MI, angina pectoris of elderly, cortical insufficiency
Adverse Effects: weight loss [not for use as this in euthyroid pt]
Pharmacokinetics:
Absorption-oral 48-79%
Half-life-7days |
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Term
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Definition
Class: thyroid drug, goitrogen
Mechanism: inhibit thyroid peroxidase, inhibits deiodinase; prevents synthesis of thyroid hormone and conversion of T4 to T3
Indications: Graves', hyperthyroidism, toxic multinodular goiter, acutely prior to thyroidectomy or radioactive iodine; PREFERRED IN PREGNANT FEMALES
Contraindications: allergy
Adverse effects: severe liver injury and acute liver failure, inc. risk of bleeding w/ oral anticoags (dec. prothrombin) |
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Term
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Definition
Class: thyroid drugs, goitrogen
Mechanism: inhibit thyroid perxodiase; inhibits synthesis of thyroid hormones
Indications: Graves', hyperthyroidism, toxic multinodular goiter, acute tx before thyroidectomy or radioactive iodine; PREFERRED FOR HYPERTHYROIDISM (LESS TOXIC, DAILY DOSE)
Contraindications: pregnancy (crosses placenta and breast milk, assoc. w/ malformations)
Adverse effects: inc. risk of bleeding w/ oral anticoags (dec. prothrombin) |
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Term
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Definition
Class: thyroid drug
Mechanism: uptake and subsequent destruction of follicular cells by radiation (B particles and g-rays)
Indications: Graves', overactive/enlarged thyroid, thyroid cancer (thyroid ablation and metastatic disease)
Contraindications: pregnancy
Adverse effects: hypothyroidism (life-long replacement), thyroiditis, worsening ophthalmopathy in Graves'
Pharmacokinetics:
Absorption-oral (solution or capsule)
Half-life-8days
Onset-few weeks
Duration-permanent |
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Term
| iodide salts/potassium iodide |
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Definition
Class: thyroid drugs
Mechanism: inhibtion of iodide uptake, inhibit iodination and organification, inhibit thyroid hormone release
Indications: emergency tx of thyroid storm, thyroid protection during tx (reduce size and vascularity before surgery), thyroid protect from nuclear accidents and emergencies
Contraindications: allergy
Adverse effects: hypothyroidism, may worsen toxic goiter symptoms
Pharmacokinetics:
Absorption - oral, reduced to iodide in intestine then absorbed; or IV
Distribution: rapid, decrease TH in 24hrs, but reversible and transient |
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Term
| propranaolol (for thyroid) |
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Definition
Class: thyroid drug, B-blocker
Mechanism: inhibits 5'-deiodinase causing decrease T4/T3 conversion and increased conc. of rT3
Indication: hyperthyroidism symptoms, thyroid storm |
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