Synthetic T4 used for thyroid hormone replacement therapy

With myxedema coma, use loading dose

Also used to suppress TSH with pit adenoma

Inhibits organification of iodide (inhibits thyroid peroxidase) and prevents peripheral conversion of T4 to T3

-preferred in pregnancy

*Agranulocytosis, goiter

Prevents organification of iodine (inhibits thryroid peroxidase)

-contraindicated in pregnancy (birth defects)

*Agranulocytosis, goiter

Tx of hyperthyroidism

accumulates in follicular cells and selectively destroys thyroid gland

*dont use in pregnancy

Give prior to surgery because high levels of iodid inhibit thyroid hormone synth

-rapid onset of actions

-reduces size and vascularity of thyroid

Increases phos and Ca absorption in the kidney by increasing expression of a Ca uptake pump, calbinding protein, and an ATP dependent pump puts into capillaries

*PTH increases production of Calcitriol

Bisphosphanate- decreases osteoclast activity

*dont give with hypoCa

*must be able to stand upright and eat a meal

Once a year dosing

Bisphosphanate-

Inhibits mineralization, increases risk of fracture

Anti-bone resorptive agent

-binds to receptors on osteoclasts, prevents bone resorption

*shouldn't be used with fish allergies