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Things I Suck At Day 3
KYCOM COMLEX
228
Medical
Graduate
07/25/2014

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Term
ions in the ECF and ICF
Definition
ECF: Na, Ca
ICF: K, phosphates, proteins
Term
roles of glycocalyx
Definition
cell cell attachment
receptor substance
nutrient attachment
Term
1. simple diffusion
2. facillitated diffusion
3. active transport
Definition
1. down concentration gradient through cell membrane or down concentration gradient through voltage or chemical gated channel

2. carrier protein binds and changes conformation to let molecule in

3. primary (ATP pump) or secondary (coupled)
Term
nernst equation
Definition
calculates potential inside the membrane if an ion were to enter the cell
the larger the potential the greater liklihood the ion will enter the cell and a greater difference in concentration of that ion between the inside and outside of the cell at rest
Term
action potential
Definition
1. RMP -70 (-90 neurons) (inside is more negative than outside)
2. stimuli causes Na influx increasing membrane potential (less negative)
3. when it crosses threshold (-70 to -50) it depolarizes (Na channel conformation change causes rapid opening)
4. K channels slowly open, at +65 equlibrium is reached and there is no more potential for Na infux. Na closes inactivation gates
5. K channels rapidly open and bring value closer to negative, past it (hyperpolarization), then to RMP
Term
motor neuron size, velocity, example
1. A-a
2. A-B
3. A-d
4. A-y
5. B
6. C
Definition
1. largest, fastest, a-motorneuron
2. medium, medium speed, touch afferent
3. small, medium speed, pain afferents
4. medium, medium speed, y-motorneuron
5. small, medium speed, ANS preganglion
6. smallest, slowest, ANS post ganglion
Term
Na channel configuration and timing
Definition
RMP: closed
depolarization: open
repolarization: inactivated
hyperpolarization: open
Term
refractory periods
Definition
absolute: during depolar/repolarization, cannot be stimulated, Na channel is inactivated

relative: hyperpolarization, Na could be activated, Na channel is open but it would take large stimuli to reach threshold
Term
MOA of receptor
1. D1
2. D2
3. kainate
4. glycine
5. GABAa
6. GABAb
Definition
1. activate adenylate cyclase
2. inhibit adenylate cyclase
3. glutamate receptor, Na/K ion channel
4. increases Cl conduction
5. increase Cl conduction
6. increase K permeability
Term
origin and ganglia of sympathetics
Definition
T1-12, L1-2
sympathetic chain
Term
orogin of parasympathetics
Definition
III, VII, IX, X, S2-4/pelvic splanchnic
Term
presynaptic neurons release ____ to a _____ receptor
Definition
ACh
Term
SNS post ganglionic that uses ACh
Definition
sweat glands and piloerector muscles
adrenal medulla
Term
receptor on skeletal muscle
receptor on all post ganglionic neurons
Definition
N2
N1
Term
locations of
1. B1
2. B2
3. A2
4. M1
5. M2
6. M3
7. M4
8. M5
Definition
1. cardiac, JG cells, B islets, adipocytes
2. coronary A, hepatocytes, gallbladder, bile ducts, bronchi, uterus, VESSELS OF SKELETAL MUSCLE
3. B islets, platelets, presynaptic neurons
4. gastric parietal, vascular smooth muscle, ANS ganglia, brain
5. heart
6. exocrine glands, smooth muscle except b ronchi and GI, vasculature (NO pathway)
7. CNS
8. CNS
Term
type of receptor
1. M1
2. M2
3. M3
4. M4
5. M5
Definition
1. Gq
2. Gi
3. Gq
4. Gi
5. Gq
Term
receptor type
1. a1
2. a2
3. B1
4. B2
Definition
1. Gq
2. Gi
3. Gs
4. Gs
Term
what receptor does sympathetic and parasympathetic for...
1. coronary artery
2. apocrine gland
3. lung vessel
4. liver
5. gall bladder
Definition
1. B2, M3
3. a1, none
3. a1, M3
4. B2, m3
5. B2, M3
Term
what receptor does sympathetic and parasympathetic for...
1. bladder
2. erection
3. ejaculation
4. pupils
5. sweat
6. salivary
Definition
1. a1, M3
2. none, M3
3. a1, none
4. a1, M3
5. cholinergic, none
6. a1, M3
Term
what receptor does sympathetic and parasympathetic for...
1. abdominal viscera arterioles
2. muscle arterioles
3. skin arterioles
4. blood coagulation
5. glucose increases
Definition
1. a1, none
2. a1 (B2 dilates), M3
3. a1, none
4. a2, none
5. a2, none
Term
sympathetic response of...
1. coronary arteries
2. apocrine glands
3. liver
4. GI sphinctors
5. rectum
Definition
1. B2 constricts
2. a1 thick secretions
3. B2 glucose release
4. a1 constrict
5. a1 allow filling
Term
parasympathetic action on
1. bladder
2. pupils
3. salivary glands
Definition
1. M3 detrusor contracts, trigone relaxes
2. M3 miosis contraction of ciruclar muscle
3. M3, vasodilation, copious secetion
Term
sympathetic action of
1. blood
2. abdominal viscera
3. mental activity
4. piloerectors
5. fat cells
6. uterus
Definition
1. a2 coagulation
2. a1 constriction
3. a2 increased
4. cholinergic contraction
5. B1 lipolysis
6. B2 relaxes
Term
receptor type
1. H2
2. H1
3. TRH
4. ACTH, TSH, FSH, LH. ADH
5. glucagona
6. GnRH
7. GHRN
8. oxytocin
Definition
1. Gs
2. Gq
3. Gq
4. Gs
5. Gs
6. Gq
7. Gq
8. Gq
Term
MOA EDRF
Definition
active component NO
released by stressed endothelial cells
stimulates guanylate cyclase to make cGMP which lowers Ca an smooth muscle causing vasodilation
Term
MOA ANP
Definition
atria over stretched > increases GFR and Na secretion, decreases blood volume, inhibits renin
stimulates gyanulate cyclase increasing cGMP
Term
MOA phosphodiesterase inhibitors
Definition
inhibits cGMP degradation
increased cGMP causes vasodilation of penile artery
Term
MOA smooth muscle contraction
Definition
endothelial or ACh > M1 > Ca mobilized > binds calmodulin > conformational change > activates Ca/calmodulin dependent kinases > activate myosin light chain kinase > acts on smooth muscle myosin to cause contraction
Term
MOA steroid hormones
Definition
diffuse through membrane
bind NR1 (cytoplasm, enter nuclei as dimer, binds to SRE, acts as TF)
or
NR2 (in nuclei, heterodimerized to RXR, binds to HRE, acts as TF)
Term
MOA tyrosine kinase
Definition
insulin binds a subunits
B subunits autophosphorlyated by TK
phosphorlyated receptor enters cell and phosphorlyates enzymes
Term
hall pike bithermal caloric test
Definition
test labrynth
30deg (horizontal semicircular canals are vertical)
irrigate ear with cold water (nystagmus should be opposite to water)
irrigate ear with warm water (should be same to ear)

named for side it moves fast to
Term
cause of each type of nystagmus
1. pendular
2. jerk, vertical, downbeat
3. jerk, vertical, upbeat
4. horizontal, peridoic alternating
5. horizontal, gaze evoked
6. horizontal, vestibular
Definition
1. cervicomedullary lesion, ocular disorder (blindness), problem with optic chiasm
2. arnold chiari, CVA, MS of medulla
3. vermis lesion, CVA, ms, tumor
4. vestivulocerebellar disease, CVA, MS, tumor
5. alcohol, depressant, cerebellar disease, brainstem lesion
6. central nuclear pathology, meineres disease, vesibular trauma
Term
parts and function of cochlea
Definition
base: narrow stiff hairs, high frequency
helicoterma: wide hairs, low frequency
Term
pathway of sound
Definition
ovarl window > moves basilar membrane > moves hairs on top > hairs bend cillia on them > cillia beinding one way increases K and the other decreases K
Term
weber test
Definition
lateralization
conductive lateralizes to bad ear
sensineuronal lateralizes to good ear
Term
rinne
Definition
bone vs air conduction
conductive BC>AC
sensineuronal AC>BC
Term
MOA golgi tendon organ
Definition
1. measures muscle tension prevention tendon overstretch, inhibit A-a motorneurons
Term
MOA muscle spindle
Definition
meausres muscle length, protects from overstretching
1A - primary afferent
2A - secondary afferent
static gamma: efferent
dynamic gamma: efferent
nuclear bag intrafusal fiber: rapid fire
nuclear chain intrafusal fiber: static response
Term
skeletal muscle contraction
Definition
large myelinated monot neurons
AP > opens Ca channels > ACh released in vesicles > N2 receptor > Na channels open > action potential > Ca released from SER > Ca binds troponin C > troponin C moves tropomycin > actin binds myosin > myosin tilts crossbridge > ATP is used to release cross bridge
Term
red vs white skeletal muscle
Definition
red: slow, marathon, posture, small muscle, low strength, low glycolytic ability, high oxidative ability, high blood supply, high mitochondria, low SER, myoglobin

white: fast fibers, rapid, powerful, large muscles, high strength, high glycolytic, low oxidative, low blood supply, low mitochondria, high SER, no myoglobin
Term
define
1. alveolar ventilation
2. dead space
3. lecithin
4. airflow
Definition
1. rate at which new air reaches alveoli
2. space with air that never reaches gas exchange
3. dipalmotoulphosphatidylcholine, surfactant
4. inverse of airway resistance
Term
calculate pressure in alveoli
Definition
P=2t/r
smaller alveoli have risk of collapse (atelectasis)
Term
calculate airway resistance
Definition
R= nL8 / pi r^4
inceases with lenfth
increased radius reduces resistance
Term
calculate airflow
Definition
Q=P/R
airflow = difference in pressure between mouth and alveoli / airway resistance
Term
movement of diaphragm in expiration
Definition
expiration: relaxes and abdominal contents rise and ribs lower and move in, air is driven out
Term
compliance of lung
Definition
inversley proportional to elastance (recoil)
inversley porportional to chest wall stiffness

C: change in lung volume / change in transmural pressure

inspiration: decreases compliance
expiration: increases compliance
expandability of lung or chest wall
Term
calculate transmural pressure
Definition
transmural = alveolar (in alveoli) - intrapleural (pressure around lung)

intrapleural drops to negative when diaphagm contracts in inspiration, increasing transmural pressure

largest at the end of inspiration and smallest at the end of expiration

large with large lung volume, small with small lung volume
Term
MOA peripherial chrmoreceptors
Definition
carotid and aortic bodies are most sensitive to CO2 but have a faster response to O2 which makes it the primary tole

carotid bodies send info through herngs nerves to glossopharyngeal then dorsal respiratory center in medullla in nucleus of tractus solitarus

aortic bodies send info via the vagus to dorsal respiratory center of medulla in nucleus of tractus solitarus

response is sent out via phrenic nerve to diaphragm
Term
apneustic center
Definition
lower pons, stimulates dorsal respiratory center to cause large sustained inspiration
Term
pneumotaxic center
Definition
upper pons, limits inspiration, inhibitory signals sent to respiratory area of medulla
Term
ventral respiratory group
Definition
anterolateral to dorsal respiratory area in nucleus ambiguus and nucleus retroambiguus

inactive in normal breathing, afferent signals from dorsal respiratory area spill over into this area they contribute to inspiration and expiration during stress or exercise
Term
lung receptors that control breathing
Definition
streth: on smooth muscle of airway, decrease respiratory rate when stretched via hering-breuer reflex

joint and muscle receptors; increase respiration in exercise

irritant receptors: between epithelial cells in airways, detect irritation, vagus nerve to medulla

J receptors next to capillaries, engorgement causes shallow fast breathing
Term
cynenne stokes respiratorion
Definition
waxing and waining amplitude
causes hypercapnea causes deep breathing then apena and repeat

cause; CHF, arrhythmia, central sleep apnea, stroke, head injury, brain tumor
Term
kussmul breathing
Definition
deep, rapid
compensate for metabolic acidosis (DKA)
Term
biot breathing
Definition
taxia respiration: quick shallow then apnea
damage to medulla
Term
ventilation vs perfusion, where is best
Definition
blood pressure and resistance are much lower than pulmonary

zone 1: V>P, highest VQ
zone 2: P>V
zone 3: P>>V, lowest VQ
Term
lung volumes
Definition
1. inspiratory reserve
2. tidal volume
3. expiratory reserve
4. residual volume
Term
lung capacities
Definition
TLC: IRV, TV, ERV, RV
inspirational C: IRV, EV
functional residual C: ERV, RV
viral C: RIV, TV, ERV
Term
SA node AP
Definition
4. upstroke: Ca enters
0. repolarization: K leaves
3. slow depolarization: slow Na entry, allows automaticity
Term
what do the waves of EKG mean
Definition
P depolarization of atria
Q depolarization of ventricles
QRS depolarization of ventricles right before contraction, repolarization of atria hidden
T: ventricle repolarization
PR interval: time of impulse in AV node
ST segment: ventricle depolarization and contraction
QT interval: entire time of ventrical depolarization and repolarization
Term
causes of
1. abnormal sinus rhythm
2. tachycardia
3. bradycardia
4. AV block
5. premature contraction
6. paroxysmal tachycardia
Definition
1. SA node generated
2. increased temp, SNS, toxicity
3. PNS
4. ischemia, compression, sacar, calcification, inflammation (myocarditis, diptheria, rheumatic), hyperPNS
5. ischemia, compression, toxicity (nicotine, drugs, caffiene)
6. ischemia to ventricle
Term
how to identify
1. 1st deg block
2. stoke adams
3. 2nd deg block
Definition
1. PR >o.2s 5 small squares
2. atria and ventricles independent (3rd)
3. going going going gone
Term
cause of missing P waves
Definition
premature contractions coming from the AV junction
Term
TX reentry / paroxysmal tachycardia
Definition
quinidine
lidocaine
Term
VFib: cause
Definition
multiple areas of ventricle contracting, circus impulses

shortened refractory: epinepherine

increased distance between impulses: dilated or enlarged hearts

decreased speed of impulse conduction: ischemia, hyperkalemia
Term
AFib causes
Definition
enlarged atria
valve disease
Term
AFlutter cause
Definition
single large impulse travels around atria, one atria contracts other relaxes
Term
mean pulmonary wedge pressure
Definition
pressure at the pulmonary capillaries
normal 8mmHg
Term
pulse pressure
Definition
systolic - diastolic
mostly affected by SV and HR
Term
estimating speed and resistance of blood flow
Definition
speed is inversely proportional to cross sectional area and is slowest in the capillaries because they have most area and fastest in aorta

resistance is porportional to viscosity and length and inversley porportional to radius to the 4th power
Term
cardiac conductance vs compliance vs capatance
Definition
conductance: ease of flow through vessel, 1/resistance

compliance = capacitance: increase in volume/increase in pressure = distensibility x volume

more compliant more it can extend at a given pressure. veins are more compliant than arteries
Term
mean arterial pressure
Definition
= 2/3 diastole + 1/3 systole
= CO x TPR
normal 70-110
Term
ejection fraction calculation
Definition
stroke volume / EDV
Term
CO calculation
Definition
= SV x HR
= (EDV-ESV) x HR
Term
SV calculation
Definition
EDV - ESV
Term
cause sof high cardiac output
Definition
generally increased TPR
beriberi: thiamine deficiency
anemia: decreases blood viscosity
hyperthyroid: increases metabolic O2 demand, reflex vasodilation
AV shunt
Term
calculate TPR
Definition
= MAP / CO
Term
what vasodilates skeletal muscle vessels
Definition
B2 receptors
K
H
lactic acid
CO2
adenosine
Term
what vasodilates cardiac muscle vessels
Definition
K
H
CO2
bradykinin
prostaglandin
adenosine
B2
Term
what causes right shift of Hb curve
Definition
2,3-BPG
CO2
acid
hot temp
Term
channels in the DCT
Definition
Cl into urine, Na out
Ca into blood, Na out
Term
channels in the principal cells
Definition
K into urine, Na out (ALD regulated)
Na into blood, K out
H2O into body (ADH regulated)
Term
channels in intercalated cells
Definition
H into urine K out
Term
path of renal vessels
Definition
renal A > afferent arterioles > glomerular capillaries > efferent arterioles > peritubular capillaries (and vasa recta that dip into loop) > renal vein
Term
calculating renal clearance
Definition
filration + secretion - reabsorption
C = (UxP)/Pa
Term
calculating renal plasma flow
Definition
clearance / extraction ratio
Term
calculating extraction ratio
Definition
ratio of solute that entered the kidney that has been excreted in the urine (PAH is nearly 1
Term
calculating renal blood flow
Definition
volume of whole blood delivered to the kidney per time
RPF x (1/1-HCT)
Term
things that decrease GFR
Definition
thickening of bomans (HTN, DM), increased bomans pressure (renal obstruction), decreased oncotic pressure in bomans or increased in capillary, decreased capillary hydrostatic (ACEI), SNS stimulation
Term
things that increase GFR
Definition
ANG II (constricts efferents more than afferents)
increased glomerular capillary hydrostatic pressure (HTN)
Term
calculating GFR
Definition
Kf ( capillary hydrostatic - bomans hydrostatic ) - (capillary oncotic - bomans oncotic )
Term
ion exchange in
1. PCT
2. loop
3. DCT
4. CD
Definition
1. reabsorbed 65% of the water, Na, Cl, K

2. resorbed water, Na, Cl, K

3. impermeable to water and urea, Na and Cl reabsorbed

4. reasorb Na, K, secrete K, H, impermable to urea
Term
body water ratios
Definition
TBD 60% weight in kg
TBD = 2/3 ICF + 1/3 ECF
ECF = 3/4 IF + 1/4 plasma
pH 7.35-7.45
Term
causes of
1. metabolic acidosis
2. metabolic alkalosis
3. respiratory acidosis
4. respiratory alkalosis
Definition
1. aspirin, lactic acid, DKA, diarrhea
2. loops, thiazides, vomiting
3. sedation, COPD, sleep apnea
4. panic, pain causing hyperventilation
Term
bodys buffers
Definition
bicarbonate - most important
proteins - within cells
Hb - binds CO2 and H in exchange for Cl
-metabolic acidosis leads to hyperkalemia
-metabolic alkalosis leads to hypokalemia
kidney - eliminates H, generates bicarb
Term
1. hypotone dehydration
2. isometric dehydration
3. hypertone dehydration
Definition
1. increased ICV, HCT, decreased ECF
2. decreased ECV, increased HCT
3. decreased ICV, ECV
Term
1. hypotonic hydration
2. isotonic hydration
3. hypertonic hydration
Definition
1. increased ICV, ECV
2. increased ECV, decreased HCT
3. increased EVC, decreased ECV, Hct
Term
stimulants of gastrin release
Definition
PNS/ACh
peptides
EtOH
caffiene
Ca
stomach distension
Term
secretin: cell, stimulation, effect
Definition
S cell of duodenum
H ions in duodenum
pancreas bicarb release
stomach motility
Term
CCK: cell, stimulation, effect
Definition
I cell duodenum/jejunum
Fat, peptides, PNS
pancreatic EXOcrine secretion
gallbladder contraction
Term
GIP: stimulation, effect
Definition
glucose, fat, AA in duodenum and jejunum
stimulates insulin secretion
inhibits parietal cells
Term
somatostatin: cell, stimulation, effect
Definition
delta cells pancrease
H in duodenum
inhibits parietal cells
inhibits exocrine pancreas
inhibits insulin and glucagon release
inhibits GH
inhibits T3/4
Term
VIP: cell, effect
Definition
smooth muscle and nervous tissue of intestine
relaxes smooth muscle
inhibits gastric acid
stimulates pancreas bicarb
Term
where are these absorbed
1. alcohol
2. carbs
3. AA
4. bile salts
5. B12
Definition
1. stomach, duodenum
2. duodenum, jejunum
3. duodenum, jejunim
4. terminal ileum
5. terminal ileum
Term
where are these absorbed
1. water
2. Na
3. bicarb
4. K
5. Fe
6. Ca
Definition
1. duodenum, jejunum, ileum, colon
2. jejunum, ileum, colon
3. jejunum, ileum
4. jejunum, ileum
5. duodenum
6. duodenum, ileum
Term
how is Na absorbed in intestines
Definition
jejunum by co-transport as a result of active uptake of sugars and AA

ileum and colon actively
Term
how is bicarb absorbed in intestines
Definition
in exchange for H ions like in the PCT but in the jejunum

ileal absorption occurs only if it is in excess

if bicarb and luminal concentrations are low ileum and colon will secrete bicarb into intestines
Term
Fe absorption
Definition
non-heme (non-meat): bind to bursh border, bind ferritin in cell, bind transferrin in blood or stay in cell and slough off

heme iron: absorbed directly into blood

increased in presence of vitamin C, alcohol, fructose

decreased with fiber, Ca, tea, coffee
Term
stimulators of conversion of cortosterone to ALD
Definition
ANG II and K
Term
stimulator of CRH release from hypothalamus
Definition
SNS
Term
enzymes needed to make
1. ALD
2. cortisol
3. Sex steroids
Definition
1. 21, 11
2. 17, 21, 11
3. 17
Term
explain the linear pathway to ALD
Definition
cholesterol > pregnelone > progesterone + 21 > 11-deoxycortisone + 11 > cortezole > (ANG II, K) > ALD
Term
explain the pathway to cortisol
Definition
pregnelone, progesterone, or cortosterone uses 17 to turn to 17-OH pregnolone, 17-OH progesterone, or cortisol respectivly

17-OH pregnolone > 17-OH progesterone + 21 > 11-deoxycortisol + 11 > cortisol
Term
explain how to make DHT and estradiol
Definition
go through pregnelone or progesterone pathway to DHEA or andeostendione respectivly using 17

DHEA > andeosteindione + 17 > testosterone + 5a-reductase > DHT

andeosteindione and testosterone can be turned into esterone and estradiol respectivly

esterone + 17 > estradiol
Term
functions of cortisol on metabolism
Definition
gluconeogenesis
insulin resistance
glycogenesis
hyperglycemia
AA mobilization from skeletal muscle
decreased protein synthesis
mobilization of fats from adipose
hyperlipidemia
Term
functions of cortisol on immune/vascular
Definition
stabilizes lysosomes (decrease activity)
prostaglandin production
decrease permeability
decrease chemotaxis
decrease T cells
decrease antibodies
increase neutrophils
decrease IL1
increase a1 vasoconstriction
decrease osteoblast
increase RBC
Term
signs of addisons
Definition
hyponatremia
hypotension
hyperkalemia
metabolic acidosis (no K/H exchange)
hypoglycemia (low cortisol)
pigmentation
Term
define
1. tumescence
2. determinate of how hard a penis is
3. factors that promote flaccidity
4. factors that promote erection
5. bulbocavernosus reflex
6. detumescence
Definition
1. vascular filling of penile corpus cavernous bodies causing erection
2. corpus cavernosal smooth muscle needs to be relaxed to fill with blood
3. NE, endothelial1, ANGII
4. ACh, NO, ATP
5. sexual stimulation forces ischiocavernous muscles to compress base of corpa cavernosa (full erection)
6. cGMP meatbolization decreases effect of NO allowing ejaculation
Term
explain menstural cycle
Definition
PROLIFERATIVE/FOLLICULAR
day 1 mensturation, rising FSH/LH
day 7 entire surface replaced to 4mm
day 14 ovulation, peak FSH/LG, estrogen and progesterone begin to rise

LUTEAL
increased estrogen and progesterone increase lipids, glycogen, vessels, glands
day 21 6mm
day 26 corups luteum degenerates
day 27 endometrium involutes, vasospasm, necrosis, decreased progesterone (causes cramps)
day 28 mensturation
Term
explain ovulation cycle
Definition
PROLIFERATIVE/FOLLICULAR
after day 1 (mensturation) FSH stimulates 12-14 follicles and granulosa secretes estrogen and fluids (antral follicle)

day 7: vesicular follicle: LH stimulates theca, one follicle predominates others atresia, estrogen increases FSH/LH receptors
day 12 FSH and LH surge
day 14: progesterone proteolysis theca (ovulation)

LUTEAL
LH turns remaining cells into lutein cells (granulosa makes estrogen and progesterone, theca makes testosterone and androstdione which can be turned into estrogen)
day 26: corpus luteum degenerates due to inadequate LH
day 27: endometrium involutes, vasospasm, necrosis, decreased progesterone causes cramps
day 28: mensturation
Term
explain baby making
Definition
sperm penetrates corona radiata and zona pellucida with acrosome

fusion of genetics forms zygote

mitosis forms blastomeres (blastula)

more mitossis forms morula (tight junctions)

divides into outer trophoblast and inner blastocyst cavity and embryoblast (blastocyst0

-trophoblast divides into synctotrophoblast and cytotrophoblast
-blastocyst cavity remains ans yolk sac
-embryoblast turns into epiblast and hypoblast and makes a hole in middle for amniotic cavity
synctotrophoblast gets lacunar filled with maternal blood which mature into lacunar network (uroplacenta circulation

cytotrophoblast develops chorionic villi that protrude into synctotrophoblast


part of the epiblast forms the extrachlonic membrane between hypoblast and cytotrophoblast

extracholionic membrane divides into etraembryonic somatic mesoderm, extraembryonic coelom (aka chorionic cavity), and extraembryonic visceral mesoderm

gasturlation occurs at 3-8wks
Term
define
1. prochordial plate
2. bilaminar embryonic disc
3. where is the baby before gasturlation
Definition
1. part of hypoblast that is between yolk sac and epiblast that is columnar
2. yolk sac, amniotic cavity, epiblast, hypoblast
3. in chorionic cavity / extraembryonic coelom on mesoderm stalk
Term
gasturlation
Definition
epiblast proliferates down midline (primitive streak = groove + node + pit)

caudal some epiblast and trophoblast fuse making cloacal membrane which turns into anus

epiblast divides into ectoderm, mesoderm, endoderm
Term
what does the ectoderm divide into
Definition
placode: sensory organs
neural tube: CNS
neural crest: smooth muscle, melanocytes, PNS, adrenal medulla

epidermis, retina, optic nerve, iris
Term
what does the mseoderm divide into
Definition
somites: dermis, muscle spine

CT, bone, cartilage, endothelium, viscera
Term
what does the endoderm divide into
Definition
hepatocytes, epithelial lining (GI, GU, middle ear, respiratory)
Term
hormone levels in puberty, menopause, PCOS
Definition
puberty: high FSH and LH
menopause: high FSH and LH, FSH>LH
PCOS low FSH, high LH
Term
in pregnancy what effects do estrogen and progesterone have on mom
Definition
estrogen: enlarge uterus, breast ducts, genitalia

progesterone: enlarge breast alveoli, uterine contraction reduction, nutrients in endometrium
Term
what is needed for make differentation
Definition
hCG binds to LH receptors on leydig cells of testes in male fetus to make testosterone
Term
define
1. spontaneous abortion
2. preterm delivery
3. term delivery
4. post term delivery
5. parturition
Definition
1. <20wks
2. 20-36wks
3. 37-41wks
4. 42wks
5. delivery of baby (estrogen high)
Term
define
1. complex seizure
2. simple seizure
3. partial seizure
4. general seizure
5. seizure
6. convulsion
Definition
1. causes LOC
2. no LOC
3. only one part of brain
4. all of brain
5. electrical overactivity
6. effect of seizure on body
Term
define
1. grand mal
2. petite mal
3. febrile seizure
4. psychomotor seizure
5. myoclonic seizure
6. jacksonian seizure
Definition
1. tonic clonic, LOC, aura, post ictal, high voltage spikes
2. generalized complex, LOC, immobile, eye fluter, 3sec spike and dome
3. secondary to fever
4. temporal lobe seizure, change in behavior, hallucination, taste, religious experience, could LOC, wallking aimlessly, lip smacking, sweating, borborygmi, spikes on temporal lobe
5. jerks, head nod, no LOC
6. moves start in one area and move to others, antral sulcus spikes
Term
pavlovian/classical conditioning vs operant/cognitive conditioning
Definition
pavlov: involuntary, lost if not conditioned

operant: voluntary, resistant to extinction
Term
motor milestones
Definition
6wk: raises chin
2mo holds head
4mo rolls over
6mo unlar grasp
7mo sits alone, stands with help
8mo pull to stand
10mo stand alone with furinature
11mo stand alone
1y walks with help, pincer grasp, sippy cup
14mo stands alone
15mo walks alone
18mo climbs stairs
2y run, kick
3y bike
4y hops
5y skips, catch ball
Term
social milestones
Definition
6wk smiles
6mo stranger anxkety
6mo separation anxkety
2y parallel play
4y cooperative play
Term
speech milestones
Definition
2mo cooing
4mo laughing
6mo babbling
8mo mama, dada indescriminate
11mo mama, dada descrmininate
1y one word clearly
15mo tandem like sentences
18mo says oen name
2y 2 word sentences
4y can tell a story
5y fluent with mispronunciation
Term
toilet milestones
Definition
2y may start training
3y potty chair with help wiping
4y can button clothes when done
Term
writing milestones
Definition
15mo lines
18mo scribbles
3y circle
4y cross
5y square, prints name
6y triangle
Term
when is moro and babinski gone, when can a child use a knife, tie shoes, dress and undress, throw things
Definition
moro 5mo
babinsky 2y
knife 6y
shoes 5y
dress 3y
throw 1y
Term
define
1. abuse
2. dependence
3. tolerance
4. addiction
Definition
1. use that results in problems at work or home, legal, danger

2. recurrent use due to need for normal function without withdrawal

3. need to increase dose to get affect

4. psychological attachent, compulsive seeking
Term
signs of intoxication
1. cocaine
2. alcohol
3. MDMA
4. GHB
5. rohypnol
6. saliva
Definition
1. confidence, energy, dilated, seizure, MI, euphoria

2. euphoria, relax, drowsi, slurring, sex dysfunction, LOC

3. energy, euphoria, distortion in time, tactile experience, empathy, hyperthermia

4. sedation, memory loss, loss of coodrination, coma

5. anterograde amnesia, sedation, muscle relaxation, confusion

6. hallucinations, dissociation, laughter, afterglow
Term
signs of intoxication
1. ketamine
2. steroids
3. LSD
4. inhalants
5. spice
6. marijuana
Definition
1. dissoication, impaired memory and attention, hallucination, dreams, delirium

2. anger, violence, mood swings, paranoia, healousy, blood clots, acne, baldness, testicle atrophy, gynecomastia, infertility, prostate CA

3. visual hallucinations, cross over delusions, paranoid delusions, dilated pupils

4. loss of inhibition, headache, slurring, loss of motor coordination

5. elevated mood, altered perception, relaxation

6. distorted perception, impaired coordination, cognitive dysfunction, increased appetite, panic, psychosis
Term
signs of intoxication
1. nicotine
2. amphetaines
3. cathinones (mepherdone)
4. phencyclidine
5. khat
6. opioids
7. benzos
Definition
1. relaxation, increased BP/HR
2. appetite supression, insmnia, attention, focus
3. hallucinations, paranoia, agitation, violence, palpitations, dilation

4 euphoria, loss of inhibition, anxiey, vuiolence, paranoia, auditory hallucination, kidney failure, arrhythmia, seizure

5. euphoria, elation, alert, manic, dilated, loss of appetite

6. euphoria, apathy, respiratory depression, pinpint pupils

7. sedation
Term
signs of withdrawal
1. cocaine
2. alcohol
3. MDMA
4. GHB
5. rohypnol
6. ketamine
Definition
1. apathy, depression, fatigue
2. tremor, hallucination, increased BP/HR
3. loss of appetite, depression, attention deficits
4. insomnia, anxiety, sweating
5. arrhythmia, anxiety
6. irritability, insomnia, depression
Term
signs of withdrawal
1. steroids
2. inhanants
3. marijuana
4. nicotine
5. amphetamines
6. mepherdone
Definition
1. mood swings, loss of lobido and appetite, insomnia
2. sweating, insomnia, hallucinatins, agressive psychosis
3. irritability, insomnia, decreased appetite, anxiety
4. irritability, increased appetite, attention deficits, sleep disturbance
5. fatigue, depression, sleep disturbance
6. fatigue, depression, decreased appetite, sleep disturbance
Term
signs of withdrawal
1. phencyclidine
2. khat
3. opioids
4. benzos
Definition
1. diarrhea, chills, tremor, seizure, hallucinations, depression, cognitive impairment, memory loss

2. nightmares, tremor

3. nausea, vomiting, sweating, fever, muscle aches

4. anxiety, insomnia, irritability
Term
signs of emotional abuse
Definition
fearful behavior
nightmares
depression
shyness
Term
signs of sexual abuse
Definition
genital pain or bleeding
STD
noctural enuresis or encopresis
extreme sexual beavior
Term
EEG signs of sleep stages
Definition
awake: B >14, a 8-13
1: a 8-13, theta 4-7
2: theta 4-7, spindles, K complexes
3: theta 4-7, delta .5-4
4: theta 4-7, delta .5-4
REM: B >14 cycles
Term
occurances in sleep stages
Definition
2: longest
3: night terrors, sleep talking/walking, enuresis, shorten with repeat cycles, replenish immune system
4: most restful and deepest
REM: REM, dreams, nightmares (remembered), paralysis of skeletal muscles except eyes, fingers, toes, increased RR, erections, consolidate memories
Term
morvans syndrome
Definition
autoimmune
anti-K channel
no sleep for months
physical and psych issues
Term
define
1. regression
2. repression
3. denial
4. rationalization
5. splitting
6. projection
Definition
1. childish response to stress
2. supression of emotion from awareness
3. ignoring but knowing your doing it
4. giving acceptible motive for behavior that is unacceptable
5. seeing as all good or bad
6. attributing to others unwanted ideas or feelings of oneself
Term
define these personality (Axis II) disorders
1. schizotypical
2. schizoid
3. avoidant
4. borderline
5. paranoid
6. antixoxcial
7. histrionic
8. narcissistic
9. dependent
10. obsessive compulsive
Definition
1. bizare clothes, behavior, perceptions, MAY BECOME SCHIZOPHRENIC
2. does not want relationships
3. wants relationships is afraid
4. intense unstable relationships, suicidial, paranoid, splitting often
5. distrust, suspicion of motives
6. .violates rights of others, no empathy, harm to animals and people
7. emotional, attention seeking, sexual
8. grandiosity, need for admiration, no empathy
9. need for care, submissive, clingy
10. perfectionism, order, control over self and others, no flexability, efficiency, and open mindedness
Term
define these somatoform disorders
1. somatization
2. conversion
3. hypochondriasis
4. body dysmorphic
Definition
1. pain, GI, and sexual complaints, pseudoneuologic complaint
2. not faking, no pain, pseudoneurologic complaints
3. fear over having disease, exaggerated symptoms
4. peroccupied with body image, hours in front of mirrior
Term
dysthmic disorder
Definition
symotoms >2y
depressed mood with appetite change, insomnia/hypersomnia, low energy, low self esteen, poor concentration

does not meet criteria for MDD
Term
bipolar 1 vs 2
Definition
1: mania and depression
2: hypomania and depression
Term
signs of bipolar mania and hypomania
Definition
grandiosity
hedonistic, promiscous
hyposonnia
psychomotor agitation
pressured speech
racing thoughts
decreased focus

hypomania: lesser mania, not socially impairing, not dangerous to self or others, productive, efficient, goal oriented
Term
define reverse tolerance
Definition
risk of psychosis increases with use
COCAINE
Term
define
1. brief psychotic disorder
2. folie a deux
3. delusional disorder
4. schizoaffective disorder
5. mood disorder with psychotic features
6. schizophreniform disorder
7. schizophrenia
Definition
1. >1d <1mo, follows trauma event
2. shared psychotic disorder
3. non bizare delusions >1mo
4. schizophrenia + mood disorder (psychosis without mood symptoms for min 2wks)
5. mood disorder with psychosis and contiued mood problems (psychosis <2wks)
6. schizophrenia <6mo
7. delusions, disorganized speech and behavior, hallusinzations, negative symptoms
Term
alport syndrome
Definition
nephritis
hearing loss
vision changes
cataracts
hereditory defect in collagen IV synthesis
Term
location of types i-5 collagen
Definition
1: bone, tendon, skin
2: hayline and cartilage
3: formed fast by young fibroblasts, artery walls and intestine
4: basement membranes, lacking in alports
5: with type 1, placenta, lacking in ehlers danlos
Term
signs of neuroblastoma
Definition
child homovanilic acid, VMA, dopamine
hypertension
painful abdominal mass
propoptosis
racoon eyes
horner syndrome
paraspinal mass
back pain
scoliosis
bladder dysfunction
diarrhea
urine catecholemines
Term
hormone responsible for BPH
Definition
dihydrotestosterone: increases prostate and stromal cells
Term
E. vermicularis
Definition
hermaphodites, nematode/roundworm
obligate human parasite
eggs hatch in duodenum, mature in colon,
perianal itching
eggs under fingernails
Term
factor V liden deficiency
Definition
inactivated protein C
V is a procoagulant that converts fibrinogen to fibrin
causes hypercoaguability
more common in caucasians
Term
why does folate cause nutritional deficiency
Definition
inhibits intestinal conjugase causing folate deficiency (monoglutamates cannot be reasorbed in jejunum)
Term
elevations in folate and B12 deficiencies and complications
Definition
folate: homocysteine
B12: bomocysteine, methylmalonic acid

homocysteine causes destruction of arteries and hypercoaguability

B12 deficiency causes subacute combined degeneration of posterior columns of the spinal cord
Term
achlorydria
Definition
HCl absences in stomach
parietal destruction in pernicious anemia
Term
SE phenytoin
Definition
fetal hydantion syndrome: cleft lip/palate
nail hypoplasia
growth retardation
mental deficiency
cardiac defects
Term
ebsteins abnormality
Definition
large RA and small RV
due to lithium use in pregnancy
Term
mayer rokitansky kruster hauser syndrome
Definition
vaginal or uterine agenesis or dysgenesis due to mullerian agenesis or dysgenesis
Term
testicular feminization syndrome
Definition
46 XY but non functional testosterne receptors
bagning of vagine with indescended testes
phenotypic female
Term
hypogonadotrophic hypogonadism
Definition
no hypothalamus or pituitary function

pituitary pathology, kallmans syndrome, tumor, TB, sarcoid of hypothalamus or pituitary, anorexia nervosa, stress, weight loss
Term
hypergonadotrophic hypogonadism
Definition
no gonad response to gonadotropins causing overactivity of pituitary and hypothalamus
Term
asherman syndrome
Definition
intrauterine synechiae and adhesions often results in amenorrhea

caused by uterine surgery, infection, D an C, medial abortion
Term
adenomyosis
Definition
growth of endometrial glands into stroma into uterine muscles
dysmenorrhea
menorrhagia
large soft uterus
Term
ovarian cysts
1. corpus luteal cyst
2. follicular cyst
3. theca lutein cyst
Definition
1. formed avter ovulation from corpus luteum, delays mensturation
2. most common, failure of follicle to rupture
3. filled with serous fluid,, high bHCG stimulation from pregnancy, choriocarcinoma, etc stimulates, BL cysts, hirsturism
Term
disorder resulting from
1. failure of mullerian paramesonephric ducts to fuse
2. defective ovary receptors
3. turner syndrome
Definition
2. bicornate uterus, double cervix, septate vagine
2. savage syndrome, primary amenorrhea
3. turner syndrome, amenorrhea
Term
word association
1. saddle injury
2. blue dot sign
4. tender swollen epididymis
5. clear fluid in tunical vaginalis
3. elephantitis of balls
Definition
1. fall onto junk, hematuria, swelling, urine in scrotum
2. appendix testes torsion
3. lymph in tunical vaginalis (wicheria banchrofti)
4. spermatocele
5. hydrocele
Term
causes of epididmyitis
Definition
boys: congenital GI abnormality
men <35y: neisseria/chalmydia
>35y: acquired anatomic abnormality

any age trauma or chemical
Term
causes of bl micro, ul micro, and bl macroorchidism
Definition
bl micro: kleinfelter, myotonic dystrophy, secondary hypogonadism

ul micro: atrophy due to mumps, syphilis, trauma

bl macro: fragile X
Term
criminal liability
Definition
accountability for a crime

felonies include failure to report child or elder abuse, euthanasia, distribution of controlled substances, gross misconduct

punishment is fine or imprisonment
Term
civil liability
Definition
breech of contract
medical malpractice
invasion of privary
invastion of person
defamation

persued by vitcim and result in monitary reward to victim
Term
1. breech of contract
2. abandonment
2. breech of confidentaility
Definition
1. failure to comply with terms in doctor patient relation, tuo types are abandoment and breech of confidentaility

2. failure to continue care or notify paient well in advance of cessation of service

3. oral, writtnd, visusal communication
Term
terms for medical malpradtice
Definition
Duty: must have dr-patient relationship

dereliction: physician did not follow standard of care

damages; there was injury or measurable damages

4. direct cause: the damages were direct result of doctors actions or intentions
Term
1. res ispa lowuitor
2. respondeat superior
3. primum non nocer
4. capacity
Definition
1. medical malpractice where duty and dereliction are unquestionable
2. physician is legially responsible for acts or inactions of employees that result in patient harm
3. above all do no harm, benifits of care must outweight risks
4. medical competence, ability to make medical decision for oneself
Term
invasion of person or privacy
Definition
bettery: examining, touching, treating without concent

informed concent: voluntairly gives permission for medical professional to do something after being informed of risks, benifits, and alternates

assault: intentional physically harming another person
Term
defamation
Definition
libel written or slander spoken

dissemination of damaging false information
Term
incapacity
Definition
inability to make medical decisions for themselves for that specific period of time for a specific medical action or inaction
only determined by a doctor, best determined by a psychitraist
Term
when is involuntary treatment ok
Definition
patient is mentally ill AND danger to self or others
Term
when is it ok to treat kid withoout parents concent
Definition
emergency
pregnancy/abortion
STDS
emancipated, married, hand child, or military
Term
1. living will
2. power of attorney
3. DNR
4. medicare
5. medicaid
Definition
1. written instruction to be followed if pt is incapacitated

2. person designated by pt during incapacitation do be surrogate for health decisions

3. no CPR, life saving tx is ok

4. >65yo

5. poor
Term
define
1. CHIP
2. managed care organization
3. HMO
4. PPO
5. fee for service
6. botique medicine
7. affordable care are
Definition
1. children health insurance program via government regardless of income

2. PPO/HMO

3. hospital/doctors are employees of insurance company and get set amount of money each month depending on # of patients assigned

4. hospital/doctor is under contract to provide reduced rate to pt insured, out of network only gets so much covered

5. do no accept insurance, often pt pays up front and submits claim themself

6. fee for service, annual fee, unlimited visits

7. federal goal to decrease uninsured by allowed preexisting conditions
Term
sensitivity
Definition
TP / (TP + FN)
Term
specificity
Definition
TN / (TN + FP)
Term
false positive ratio
Definition
1-specificity
Term
prevalence
Definition
number of people ina population with a disease
Term
incidence
Definition
number of new cases in a population per given time
Term
mortality
Definition
# of people who die per given time due to disease
Term
negative perdictive value
Definition
probability disease free despite a negat test. can you rely on a a negative test?

TN / (FN + TN)
Term
positive perdictive value
Definition
probability pt has disease if their test is positive. can you rely on a positive test?

TP / (FP + TP)
Term
odds ratio
Definition
risk of anyone in a population getting this disease
>1 at risk of infection due to factor
<1 not risk of infection due to factor

TPxTN / FPxFN
Term
relative risk
Definition
compares risk of those who were exposed getting the disease to those not exposed

TP/(TP+FP) / FN/(FN+TN)
Term
standard deviation
Definition
one SD 68%
two SD 95%
three SD 99%
Term
define
1. reliability
2. validity
3. percision
4. percision
5. accuracy
6. mean
7. median
Definition
1. dependability of a test, reproducable test results

2. determination of how appropirate a test is for given situation

3. consistancy

4. trueness of result

5. average

6. middle of values
Term
null hypothesis
type 1 error
type 2 error
Definition
Ho: says there is NO correlation between disease and risk factor, supporting Ho means your study sucked

1: says it does not support Ho but is really does (a)

2: says it supports Ho but it really doseast (B)
Term
define
1. clinical tria
2. chohort
3. case control
4. cross sectional
5. meta analysis
6. prospective study
7. retrospective study
Definition
assess threapeutic benifit of tgreatment, standard before FDA approval

2. real time, follow disease, study effect of risk factors to characterize them

3. follow patents known to have and not have disease

4. correlations between variables (1 means perfect correlation, 0 means none, -1 means negative)

5. collection of data from multiple studies

6. study done here and now (chohort)

7. medical records and data collected prior to the study analized (case control)
Term
foramen ovale
Definition
aka osteum secundum

allows blood from RA to LA
Term
ductus arterosus
Definition
ligamentum arterosum

connects pulmonary artery to aortic arch
Term
ductus venosus
Definition
lugamentum venosum

shunts blood from umbilical vein to IVC
Term
umbilical arteries
Definition
medial umbilical ligaments

deoxygenated blood to placenta
2 in umbulicla cord
Term
umbilical vein
Definition
ligamentum teres hepatis (round ligament)

deliver oxygenated blood from placenta
Term
urachus
Definition
median umbilical ligament

connects bladder with allantois
Term
yolk stack
Definition
meckels diverticulum

2% of people
2cm long
2 ft from ileocecal junction

inflammation immitates appendicitis
Term
causes of anion gap metabolic acidosis
Definition
CUTE DIMPLES
cyanide
uremia
toluene
ethanol
DKA
isoniazid
methanol
propylene glycol
lactic acidosis
ethylene glycol
salicylates
Term
causes of non-anion gap metabolic acidosis
Definition
CARD

carbonic anhydrase inhibitors
addisons
RTA
diarrhea
Term
portal systemic anastomoses for
1. esophagus
2. caput medusa
3. hemorrhoids
Definition
1. L gastric vein and azygos vein
2. paraumbilical veins and inferior epigastric veins
3. superior rectal vein and inferior rectal vein
Term
taysachs vs neimann pick
Definition
tay sachs: AR, sphingolipidosis, lysosomal storage disorder, Jews, decreased motor, paralysis, MR, blindness, hyperacusis (startle), cherry red spot

neimann pick: AR, lysosomal storage, sphingomyelinase, MR, death 2-3yo, hepatosplanomeagly, cherry red spot
Term
signs of krabbes disease
Definition
AR lysosomal storage
deficiency in B-galactosidase
accumulation of cerebrosides
fatal early
MR, blindness, deafness, paralysis, confulsions
Term
signs of gauchers disease
Definition
AR
lysosomal storage
- B-gluosidase
Jews
cerebroside accumulation in RES
HSM, MR, skeletal deformities
erosion of long bones
osteoperosis45
Term
muscles of pelvic diaphragm
Definition
levator ani: peuborectus, pubococcygeus, iliococcigeus
coccygeys
males pelvic floor, raises it, constrict rectum and vagina
Term
innervation of piriformis
Definition
S1-2
Term
innervation of iliopsoas
Definition
L1-3 and femoral L2-3
Term
muscles and sensory of the lumbar plexus
Definition
T12-L4
iliopsoas
quads
adductors
satorus
gracilis
sensation: thigh, butt, lower abdominal, pubes
Term
muscles and sensory of the sacram plexus
Definition
L4-S4
motor and sensory to pelvis and LE
PNS S2-4 to left colon

sciatic: L4-S3
Term
what inominate dysfunctions cause dysuria and frequency
Definition
inflare, superior shear
Term
most common sacral function after delivery
Definition
bilateral flexion
Term
most common sacral dysfunction
Definition
unilateral flexion
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