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Therapeutics #2 - Nutrition
N/A
38
Health Care
Graduate
10/17/2009

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Cards

Term
Role of Diet in Low-Risk Disease Management
Definition
diet & lifestyle changes tried before drugs are used
Term
Role of Diet in High-Risk Disease Management
Definition
diet & drug therapy are started simultaneously
Term
Marasmus
Definition
protein-energy malnutrition; decreased protein intake & decreased energy; decreased fat, somatic protein, and immune function with normal visceral protein; EX: wasting syndrome, cancer cacchexia
Term
Kwashiorkor
Definition
protein malnutrition; decreased albumin & protein; normal somatic protein & fat; decreased albumin & immune function; distention of stomach; EX: catabolic states (burn, trauma)
Term
Mixed Marasmus-Kwashiorkor
Definition
combination of protein & energy malnutritions; decreased fat, somatic protein, visceral protein (albumin), and immune function; EX: hypermetabolic states in critically ill
Term
Nutrition Screening
Definition
identifies patients who are overweight, obese, malnourished, or at risk of malnutrition; simple checklists administered within 72 hrs of admission by clinicians and/or non-clinicians; refer at-risk patients to clinicians who can do something about it (PMD, RD, etc.)
Term
Nutrition Assessment
Definition
usually performed by a dietician; physical assessment: anthropmetrics (BMI), lab data, general appearance, skin & mucous membranes, musculoskeletal system, neurologic, hepatic; weight changes in previous 6 months: 1-2% in 1 wk, 5% in 1 month, 7.5% in 3 months, 10% in 6 months; dietary intake changes; GI symptoms; functional capacity of GI tract; presence of disease states
Term
Ideal Body Weights
Definition
Male (kg) = 50 + 2.3*(every inch > 5 ft); Female (kg) = 45 + 2.3*(every inch > 5 ft); Obese (kg) = [0.25(ABW-IBW)] + IBW
Term
Body Mass Index (BMI)
Definition
undernourished = < 18.5; normal weight = 18.5 - 25; obese = > 30
Term
Adult Fluid Requirements
Definition
30-40 mL/kg/day; Replace: diarrhea, fistulas; Increase: fever; Decrease: HF, fluid restriction; Peds: weight dependent, increase with fever
Term
Adult Energy Requirements
Definition
20-30 kcal/kg
Term
Carbohydrate Calories
Definition
3.4 kcal/gm; < 7 gm/kg/day; start low & slowly increase as tolerated; 70-85% of non-protein calories
Term
Protein Calorie Requirements
Definition
4 kcal/gm; 6.25 gm protein = 1 gm nitrogen; usual range: 0.8 - 2 gm/kg/day; catabolic range: 1.2 - 2 gm/kg/day
Term
Fat Calories
Definition
9 kcal/gm; 15-30 % of non-protein calories; omit on first day just in case patient has a reaction; < 2.5 gm/kg/day
Term
To gain or lose 1 lb (0.45 kg) per week:
Definition
add or subtract 500 kcal/day
Term
Reasons patients are underfed
Definition
obesity, multiple organ dysfunction, uncomplicated infection, hypermetabolism
Term
Reasons patients are Overfed
Definition
underlying malnutrition, severe traumatic injury, sepsis
Term
Consequences of Underfeeding
Definition
decreased respiratory muscle strength, impaired organ function, immunosuppression, poor wound healing, increased risk of HCA infection
Term
Overfeeding Consequences
Definition
hyperglycemia, azotemia, hypertriglyceridemia, electrolyte imbalance, immunosuppression, altered hydration status, hepatic toxicity
Term
Macronutrient Components of Nutrition Formula
Definition
protein, dextrose, lipids, fluids
Term
Indications for Enteral Nutrition
Definition
dysphagia (inability to swallow); obstruction of mouth, throat, esophagus, stomach; major burns, trauma, organ system failure; radiation/chemotherapy; fistulas
Term
Contraindications for Enteral Nutrition
Definition
disease states or pre- or post-surgery requiring GI rest; increased chance for aspiration, coughing, vomiting; non-functioning GI tract; obstruction of ileus; severe GI bleed; severe, intractable diarrhea; need < 5-7 days
Term
Fiber
Definition
important in enteral feeding; maintenance of normal bowel habits, lowers BP & cholesterol; degraded by colon bacteria into short-chain fatty acids
Term
Continuous Enteral Administration
Definition
administered over 10-24 hrs via pumps or gravity systems; preferred for critically ill patients; start at 20-50 mL/hr & advance by 10-25 mL q4-8 hrs until desired rate is achieved
Term
Intermittent Enteral Administration
Definition
8-16 oz. infused over 20-60 min; start with 120 mL every 4 hrs and advance by 30-60 mL every 8-12 hrs; assure bag/syringe hygiene & adequate flushing with water; more consistent physiologically with normal eating patterns; not appropriate for duodenal or jejunal feedings
Term
Types of Enteral Feeding Routes of Administration
Definition
nasogastric tube; nasoduodenal tube; nasojejunal tube; percutaneous endoscopic gastrostomy (PEG) tube;
Term
Drug-Nutrient Interactions
Definition
minerals/electrolytes <-- diuretics; hyperglycemia <-- corticosteroids, cyclosporine; hypoglycemia <-- insulin hypoglycemics; decreased folic acid <-- sulfasalazine; pyrodoxine deficiency <-- isoniazid; decrased thiamin <-- furosemide; decreased methotrexate effect <-- folic acid; altered warfarin effect <-- vitamins K & E; drug vehicles --> volume & calories
Term
Medications & Enteral Nutrition
Definition
know where the tip of feeding tube is (antacids should not be given thru J-tube); use liquid dosage forms if possible; when liquid dosage forms are not available: crush solid meds & mix with 20-30 mL H2O, flush with 5 mL H2O between meds, DON't crush SR & XL forms; DO NOT place meds directly in EN formula
Term
Drug-EN Interactions
Definition
Phenytoin: seizure med, decreased bioavalability, Hold EN x 2 hr around dose, increase dose; Select antibiotics (quinolones & tetracyclines): decreased bioavailability, hold feeding prior to & after dose; Warfarin: anticoagulant, decreased absorption, adjust based on INR; PPIs: crushing granules leads to degradation by stomach acid, omeprazole may clog, don't crush pantoprazole, lansoprazole & omeprazole suspension administer via tube
Term
Peripheral Administration of PN
Definition
short peripheral, midline; < or = to 10% Dextrose final concentration; dilute solutions may not be complete PN; osmolarity of blood = 280-300 mOsm/L
Term
Central Venous Catheters in PN
Definition
tunneled catheters, ports, PICC; into right vena cava; osmolarity 1500-2250 mOsm/L;
Term
Parenteral Nutrition Indications
Definition
non-functioning GI tract; prolonged bowel rest requireed; severe malnutrition; hypermetabolic states (no PO intake for 7-14 days)
Term
Parenteral Nutrition Contraindications
Definition
short term, functioning GI tract, lack of venous access, hemodynamic instability, poor prognosis where aggressive treatment is not desired
Term
Trace Elements in PN
Definition
Chromium: insulin-mediated reactions, renal excretion; Copper: transferrin reactions, RBC/WBC formation, biliary excretion; Manganese: enzyme activation, biliary excretion; Selenium: cell protection from oxidative damage, renal excretion; Zinc: enzyme cofactor, wound healing, excreted via GI tract
Term
Mechanical Complications of PN
Definition
pump failure, tubing failure, catheter malposition/misdirection/migration; air embolism; catheter occulusion; catheter puncture or breakage
Term
Physiological Complications of PN
Definition
infection (most frequent occurring); Metabolic complications: hyperglycemia, hypoglycemia, electrolyte imbalance, fluid overload, dehydration, refeeding syndrome, allergic reactions, overfeeding, hypertriglyceremia, liver toxicities, aluminum toxicity, bone disease, FA deficiency, gall bladder complications
Term
Refeeding Syndrome
Definition
severe malnutrition with significant weight loss causes pt to receive aggressive nutrition supplementation; at risk: cancer, cardiac cachexia, COPD, cirrhosis, previous morbid obesity, massive weight loss; causes hypophosphatemia, hypokalemia, & hypomagnesemia
Term
Minimizing Refeeding Syndrome
Definition
identify high risk pts before initiating NST; start carbohydrate infusion at 1.25-1.5 g/day; feed 25% of calorie needs days 1-2, increase gradually to goal caloric requirements over 7 days by 10%/day; correct phosphorus, potassium, & magnesium abnormalities prior to initiating nST; maintain weight gain < 1 kg/week; restrict fluid to 25 mL/kg; restrict Na to 30-60 mEq/day
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